Original Full Length Article Autologous bone marrow cell implantation in the treatment of non-traumatic osteonecrosis of the femoral head: Five year follow-up of a prospective controlled study

Objective: To determine the efficacy of bone marrow cell implantation into the necrotic lesion of the femoral head on clinical symptoms and the progression of osteonecrosis of the femoral head in comparison with core decompression. Methods: We studied nineteen patients and twenty four hips with early stage osteonecrosis of the femoral head. The hips were allocated to either core decompression only or core decompression and implantation of bone marrow cells. Both patients and assessors were blind with respect to treatment group assignment. The primary outcomes were clinical symptoms and disease progression. Results: Bone marrow implantation afforded a significant reduction in pain and in joint symptoms and reduced the incidence of fractural stages. At 60 months, eight of the eleven hips in the control group had deteriorated to the fractural stage whereas only three of the thirteen hips in the bone marrow graft group had progressed to that stage. Survival analysis showed a significant difference in the time to failure between the two groups at 60 months. Patients had only minor side-effects after the treatments. Conclusions: This long term follow-up study confirmed that implantation of autologous bone marrow cells in the necrotic lesion might be an effective treatment for patients with early stages of osteonecrosis of the femoral head

The Number of X Chromosomes Influences Inflammatory Cytokine Production Following Toll-Like Receptor Stimulation

Sex differences are observed in the evolution of numerous inflammatory conditions. Women exhibit better clinical courses compared to men in acute inflammatory processes, yet worse prognosis in several chronic inflammatory diseases. Inflammatory markers are significantly different between prepubertal boys and girls, whose sex steroid levels are very low, suggesting genetics play a role. To evaluate the potential influence of the X chromosome, we studied cytokine production and protein phosphorylation following Toll-like receptor (TLR) activation in whole blood and purified neutrophils and monocytes of healthy adults of both sexes as well as subjects with Klinefelter syndrome. We recorded higher levels of inflammatory cytokines in men compared to both women and patients with Klinefelter syndrome following whole blood stimulation. In purified monocytes, production of inflammatory cytokines was also higher in men compared to women, while Klinefelter subjects expressed the same pattern of cytokine production as males, in contrast with whole blood analyses. These differences remained after adjusting for sex steroid levels. Our study revealed higher cytokine inflammatory responses in men than women, yet also compared to subjects with Klinefelter syndrome, who carry two copies of the X chromosome, like women, and thus potentially benefit from the cellular mosaicism of X-linked genes

Biostatistique

PHARMA2, EDPH3S, EDPH3P, EDPH3M, KINE3, RADIOBC, STAT033info:eu-repo/semantics/published

Biostatistique :Présentations Powerpoint 2010-2011

MEDE2, VETE2, DENT2, BIME2, KINE3, MOTR3 - STAT-G-201/STAT-I-301info:eu-repo/semantics/published

Biostatistique

MEDE2, DENT2, VETE2, BIME2, KINE3, MOTR3, STAT-G-201/STAT-G-202/STAT-G-203/STAT-I-301info:eu-repo/semantics/published1

Biostatistique :Exercices pratiques

4e édition 2001-02/1MED2, DENT2, VETE2, BIME2B, BIME2S, SAPU3G, SAPU3P, STAT088info:eu-repo/semantics/published

Éléments de statistiques appliquées aux sciences biomédicales

3e candidature en sciences médicales, 1re licence en science dentaire, 2e candidature sciences biomédicales, 2e candidature sciences vétérinaires - STAT 0882e édition 1997-1998/1info:eu-repo/semantics/published

Biostatistique

Syllabus strictement réservé aux étudiants suivant le cours de "Biostatistique", 2e candidature sciences pharmaceutiques, 1re licence kinésithérapie, 1re licence éducation physique - STAT 033info:eu-repo/semantics/published

Biostatistique

MED2, DENT2, VETE2, BIME2B, BIME2S, SAPU3G, SAPU3P, SAPUL, STAT088info:eu-repo/semantics/published

Biostatistique

MED2, DENT2, VETE2, BIME2B, BIME2S, SAPU3G, SAPU3P, SAPUL, STAT088info:eu-repo/semantics/publishe