4 research outputs found

    Environmental assessment of an abandoned briquette factory – a case study at Nagymányok area, former industrial zone

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    The study is focused on environmental assessments of impacts by former briquette factory at the Nagymányok area in South Hungary. The (former) industrial zone is located in a northern valley of the Eastern Mecsek Mountains. Until the 1990s this company was the largest briquette factory in Hungary and the demolition works are still incom- plete. Former investigations were based on only fve samples. Our sampling sites were selected on the basis of the source of the contaminations and then we covered the whole area in equal distribution. We used the A1-F6 codes for the sample places. We have started from southwest to northeast. The samples were analyzed for Total Petrol Hydro- carbons (TPHs), Polycyclic Aromatic Hydrocarbons (PAHs) and for heavy metals. The area was heavily contaminated by TPHs and moderately heavy metals (such as Cu, Cr, Zn and Pb). Highest contaminant concentrations were found around the former industrial buildings, especially between the boiler-house and the coal-pillbox. In the industrial area the mean of the detected values is below the upper limit of the legal exposure values, but among the former industrial buildings higher (e.g. toxic level) concentration values were detected in multiple samples. Based on our investigation the pollutant can be transported by wind or by water on the surface (stream bed) or underground. The hazardous ma- terial can easily reach some part of the city, therefore reclamation is necesarry

    Environmental assessment of an abandoned briquette factory – a case study at Nagymányok area, former industrial zone

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    The study is focused on environmental assessments of impacts by former briquette factory at the Nagymányok area in South Hungary. The (former) industrial zone is located in a northern valley of the Eastern Mecsek Mountains. Until the 1990s this company was the largest briquette factory in Hungary and the demolition works are still incom- plete. Former investigations were based on only fve samples. Our sampling sites were selected on the basis of the source of the contaminations and then we covered the whole area in equal distribution. We used the A1-F6 codes for the sample places. We have started from southwest to northeast. The samples were analyzed for Total Petrol Hydro- carbons (TPHs), Polycyclic Aromatic Hydrocarbons (PAHs) and for heavy metals. The area was heavily contaminated by TPHs and moderately heavy metals (such as Cu, Cr, Zn and Pb). Highest contaminant concentrations were found around the former industrial buildings, especially between the boiler-house and the coal-pillbox. In the industrial area the mean of the detected values is below the upper limit of the legal exposure values, but among the former industrial buildings higher (e.g. toxic level) concentration values were detected in multiple samples. Based on our investigation the pollutant can be transported by wind or by water on the surface (stream bed) or underground. The hazardous ma- terial can easily reach some part of the city, therefore reclamation is necesarry

    Remodeling of Liver and Plasma Lipidomes in Mice Lacking Cyclophilin D

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    In recent years, several studies aimed to investigate the metabolic effects of non-functioning or absent cyclophilin D (CypD), a crucial regulatory component of mitochondrial permeability transition pores. It has been reported that the lack of CypD affects glucose and lipid metabolism. However, the findings are controversial regarding the metabolic pathways involved, and most reports describe the effect of a high-fat diet on metabolism. We performed a lipidomic analysis of plasma and liver samples of CypD-/- and wild-type (WT) mice to reveal the lipid-specific alterations resulting from the absence of CypD. In the CypD-/- mice compared to the WT animals, we found a significant change in 52% and 47% of the measured 225 and 201 lipid species in liver and plasma samples, respectively. The higher total lipid content detected in these tissues was not accompanied by abdominal fat accumulation assessed by nuclear magnetic resonance imaging. We also documented characteristic changes in the lipid composition of the liver and plasma as a result of CypD ablation with the relative increase in polyunsaturated membrane lipid species. In addition, we did not observe remarkable differences in the lipid distribution of hepatocytes using histochemistry, but we found characteristic changes in the hepatocyte ultrastructure in CypD-/- animals using electron microscopy. Our results highlight the possible long-term effects of CypD inhibition as a novel therapeutic consideration for various diseases
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