Multiple hepatic lesions in a case of isolated hepatic tuberculosis simulating metastases on 18F-FDG PET/CT imaging

Hepatic tuberculosis is an unusual form of extrapulmonary tuberculosis and constitutes less than 1% of all cases of tuberculosis. Imaging studies for hepatic tuberculosis are nonspecific and mimic primary or metastatic carcinoma. Here we present 18F-FDG PET/CT images of a 25-year-old male patient with isolated hepatic tuberculosis

Revisiting Prostate Cancer in India: A Genomic View

In the recent past, there has been a rise in Prostate Cancer (PCa) in Asia, particularly India.  Although systematic reviews on PCa have dealt on the genetics, genomics and the environmental influence in causal of PCa, no predictive analytics in comparing the PCa from Caucasian, American to Asian population was attempted. In this review article, we have attempted to elaborate this aspect of PCa and deliberated on challenges related to next generation sequencing methods of PCa’s manifestation when compared to the west

Histiocytic Sarcoma of Submandibular Gland: A Rare Case Report

Histiocytic Sarcoma (HS) is a rare malignant neoplasm characterised by the neoplastic proliferation of cells showing morphological and immunophenotypic features of mature histiocytes. Majority of the reported cases present in extranodal sites, such as the head and neck, thyroid, duodenum, small intestine, colon, urinary bladder, spleen, and leptomeninges. This report documents a case of primary involvement of the salivary gland by HS. A 77-year-old male patient presented with a firm swelling in the left submandibular region for the last three months. Multiple lymph nodes, along with the presence of lung and liver nodules, were seen. Thus the final diagnosis of HS was made based on histopathology and IHC. Palliative chemotherapy was given to the patient, responded well, and has been well for the last year. The present study is probably the first case of HS involving the submandibular gland

A Pilot Study on the Whole Exome Sequencing of Prostate Cancer in the Indian Phenotype Reveals Distinct Polymorphisms

Prostate cancer (PCa) is the third most common cancer among men in India, and no next-generation sequencing (NGS) studies have been attempted earlier. Recent advances in NGS have heralded the discovery of biomarkers from Caucasian/European and Chinese ancestry, but not much is known about the Indian phenotype/variant of PCa. In a pilot study using the whole exome sequencing of benign/PCa patients, we identified characteristic mutations specific to the Indian sub-population. We observed a large number of mutations in DNA repair genes, viz. helicases, TP53, and BRCA besides the variants of unknown significance with a possibly damaging rare variant (rs730881069/chr19:55154172C/TR136Q) in the TNNI3 gene that has been previously reported as a semi-conservative amino acid substitution. Our pilot study attempts to bring an understanding of PCa prognosis and recurrence for the Indian phenotype.</p