Disordered Adrenocorticotropin Secretion in Women with Major Depression

Context: Major depression is accompanied by activation of the hypothalamic pituitary axis and evidence of abnormalities in circadian and ultradian hormone rhythms. In addition, diminished negative feedback of cortisol on adrenocorticotropin (ACTH) has been found. Objective: To compare ACTH and cortisol hormonal patterns in women with major depression to normal control women. Design: Case control study. Setting: General-Clinical Research Center Patients and Other Participants: Healthy, drug free, premenopausal women with major depression and age and menstrual cycle day matched healthy control women. Main Outcome Measure: ACTH and cortisol data measured every 10 minutes for 24H analyzed with approximate entropy and cross-approximate entropy to determine orderliness of hormone secretion and relationship between ACTH and cortisol in terms of feed forward and feedback synchrony. Results: Depressed women manifested increased approximate entropy, indicating more disorderly secretion, of ACTH and elevated forward cross-approximate entropy of ACTH on cortisol, denoting unopposed ACTH drive. Conclusions: These data support other evidence of hormonal rhythm abnormalities in depression and are compatible with accentuated feedforward drive by ACTHNIMH MH 50030 NIDK DK 06717Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/49485/2/YoungandVeldhuis.pd

Identification performance of evidential value estimation for ridge-based biometrics

Law enforcement agencies around the world use ridge-based biometrics, especially fingerprints, to fight crime. Fingermarks that are left at a crime scene and identified as potentially having evidential value (EV) in a court of law are recorded for further forensic analysis. Here, we test our evidential value algorithm (EVA) which uses image features trained on forensic expert decisions for 1428 fingermarks to produce an EV score for an image. First, we study the relationship between whether a fingermark is assessed as having EV, either by a human expert or by EVA, and its correct and confident identification by an automatic identification system. In particular, how often does an automatic system achieve identification when the mark is assessed as not having evidential value? We show that when the marks are captured by a mobile phone, correct and confident automatic matching occurs for 257 of the 1428. Of these, 236 were marked as having sufficient EV by experts and 242 by EVA thresholded on equal error rate. Second, we test four relatively challenging ridge-based biometric databases and show that EVA can be successfully applied to give an EV score to all images. Using EV score as an image quality value, we show that in all databases, thresholding on EV improves performance in closed set identification. Our results suggest an EVA application that filters fingermarks meeting a minimum EV score could aid forensic experts at the point of collection, or by flagging difficult latents objectively, or by pre-filtering specimens before submission to an AFIS

Actions of NPY, and its Y1 and Y2 receptors on pulsatile growth hormone secretion during the fed and fasted state

The hypothalamic NPY system plays an important role in regulating food intake and energy expenditure. Different biological actions of NPY are assigned to NPY receptor subtypes. Recent studies demonstrated a close relationship between food intake and growth hormone (GH) secretion; however, the mechanism through which endogenous NPY modulates GH release remains unknown. Moreover, conclusive evidence demonstrating a role for NPY and Y-receptors in regulating the endogenous pulsatile release of GH does not exist. We used genetically modified mice (germline Npy, Y1, and Y2 receptor knock-out mice) to assess pulsatile GH secretion under both fed and fasting conditions. Deletion of NPY did not impact fed GH release; however, it reversed the fasting-induced suppression of pulsatile GH secretion. The recovery of GH secretion was associated with a reduction in hypothalamic somatotropin release inhibiting factor (Srif; somatostatin) mRNA expression. Moreover, observations revealed a differential role for Y1 and Y2 receptors, wherein the postsynaptic Y1 receptor suppresses GH secretion in fasting. In contrast, the presynaptic Y2 receptor maintains normal GH output under long-term ad libitum-fed conditions. These data demonstrate an integrated neural circuit that modulates GH release relative to food intake, and provide essential information to address the differential roles of Y1 and Y2 receptors in regulating the release of GH under fed and fasting states

Pseudo Identities Based on Fingerprint Characteristics

This paper presents the integrated project TURBINE which is funded under the EU 7th research framework programme. This research is a multi-disciplinary effort on privacy enhancing technology, combining innovative developments in cryptography and fingerprint recognition. The objective of this project is to provide a breakthrough in electronic authentication for various applications in the physical world and on the Internet. On the one hand it will provide secure identity verification thanks to fingerprint recognition. On the other hand it will reliably protect the biometric data through advanced cryptography technology. In concrete terms, it will provide the assurance that (i) the data used for the authentication, generated from the fingerprint, cannot be used to restore the original fingerprint sample, (ii) the individual will be able to create different "pseudo-identities" for different applications with the same fingerprint, whilst ensuring that these different identities (and hence the related personal data) cannot be linked to each other, and (iii) the individual is enabled to revoke an biometric identifier (pseudo-identity) for a given application in case it should not be used anymore