Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Correlation between the length and breadth of the nose and the face in different races

This study is aimed at determining whether there exists a correlation between the relative dimensions of the nose and the face. Through this study, we hoped to give a normal range for the different races in Malaysia. We randomly chose 100 Malay, 50 Chinese and 50 Indian subjects. We chose equal numbers of male and female subjects, mainly in their 20's and 30's. There is a correlation between the length of the nose and the face among Malays, with 78% of the subjects measured having a nose:face ratio of less than 0.27. There is also a correlation between the breadth of the nose and the face among Malays, with 670/0 of the subjects having a ratio of less than 0.28. Similar correlations were found with Chinese and Indian subjects. The length and breadth of the nose in relation to the face is greater in males than in females. Further research is required before conclusive evidence is found for the existence or non existence of a correlation between the length and breadth of the nose and face in the different races in Malaysia