2 research outputs found
Instalaci贸n y configuraci贸n del S.O. zentyal server 6.2 para disponer de los servicios de infraestructura IT
El presente trabajo muestra una soluci贸n basada en GNU/Linux a trav茅s de la instalaci贸n, configuraci贸n y puesta en marcha de Zentyal Server como sistema operativo base para disponer de los servicios de Infraestructura IT que permiten dar Soluci贸n a necesidades espec铆ficas. Se implement贸 bajo el Zentyal Server servicios de gesti贸n de infraestructura IT como DHCP Server, DNS Server y Controlador de
Dominio, Proxy no transparente, cortafuegos, VPN, File Server y Print ServerThis work shows a solution based on GNU / Linux through the installation, configuration and start-up of Zentyal Server as a base operating system to have IT Infrastructure services that allow to provide a solution to specific needs. It was implemented under the Zentyal Server IT infrastructure management services such as DHCP Server, DNS Server and Controller of Domain, Non-transparent Proxy, Firewall, VPN, File Server and Print Serve
Impact of vaccination against COVID-19 on patients with cancer in ACHOC-C19 study: Real world evidence from one Latin American country
Introducci贸n: Durante la pandemia, se ha recomendado que la vacunaci贸n contra COVID-19 sea una prioridad para los pacientes con c谩ncer; sin embargo, estos pacientes no se incluyeron en los estudios iniciales de evaluaci贸n de las vacunas disponibles. Objetivo: Definir el impacto de la vacunaci贸n contra COVID-19 en la prevenci贸n del riesgo de complicaciones asociadas a la infecci贸n en una cohorte de pacientes con c谩ncer en Colombia. M茅todos: Se realiz贸 un estudio observacional anal铆tico de cohorte, basado en el registro nacional de pacientes con c谩ncer e infecci贸n por COVID 19 ACHOC-C19. Los datos se recolectaron desde junio de 2021, hasta octubre de 2021. Los criterios de inclusi贸n fueron: Pacientes mayores de 18 a帽os con diagn贸stico de c谩ncer e infecci贸n confirmada por COVID-19. Se compararon los datos de las cohortes no vacunadas y vacunadas. Los resultados evaluados incluyeron mortalidad por todas las causas en los 30 d铆as siguientes al diagn贸stico de COVID-19, hospitalizaci贸n y necesidad de ventilaci贸n mec谩nica. La estimaci贸n del efecto se realiz贸 mediante el riesgo relativo (RR), la reducci贸n absoluta del riesgo (RRA) y el n煤mero necesario a tratar (NNT). El an谩lisis multivariante se realiz贸 mediante modelos lineales generalizados. Resultados: Se incluyeron 896 pacientes, de los cuales 470 eran mayores de 60 a帽os (52,4%) y el 59% eran mujeres (n=530). Se reclutaron 172 pacientes en la cohorte vacunada y 724 en la cohorte no vacunada (ratio: 1 a 4,2). La incidencia acumulada de resultados cl铆nicos entre los pacientes no vacunados frente a los vacunados fue: para hospitalizaci贸n 42% (IC 95%: 38,7%-46,1%) frente a 29%; (IC 95%: 22,4%-36,5%); para requerimiento de ventilaci贸n mec谩nica invasiva 8,4% (n=61) frente a 4,6% (n=8) y para mortalidad por todas las causas 17% (n=123) frente a 4,65% (n=8). Conclusiones: En nuestra poblaci贸n, los pacientes con c谩ncer no vacunados tienen un mayor riesgo de complicaciones por infecci贸n por COVID -19, como hospitalizaci贸n, ventilaci贸n mec谩nica y mortalidad. Es muy recomendable promover activamente la vacunaci贸n entre esta poblaci贸n. El autor (es). Este es un art铆culo de acceso abierto distribuido bajo los t茅rminos de la Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). Consulte los t茅rminos y condicionesIntroduction: During the pandemic, it has been recommended that vaccination against COVID-19 be a priority for patients with cancer; however, these patients were not included in the initial studies evaluating the available vaccines. Objective: To define the impact of vaccination against COVID-19 in preventing the risk of complications associated with the infection in a cohort of patients with cancer in Colombia. Methods: An analytical observational cohort study, based on national registry of patients with cancer and COVID 19 infection ACHOC-C19, was done. The data was collected from June 2021, until October 2021. Inclusion criteria were: Patients older than 18 years with cancer diagnosis and confirmed COVID-19 infection. Data from the unvaccinated and vaccinated cohorts were compared. Outcomes evaluated included all-cause mortality within 30 days of COVID-19 diagnosis, hospitalization, and need for mechanical ventilation. The estimation of the effect was made through the relative risk (RR), the absolute risk reduction (ARR) and the number needed to treat (NNT). Multivariate analysis was performed using generalized linear models. Results: 896 patients were included, of whom 470 were older than 60 years (52.4%) and 59% were women (n=530). 172 patients were recruited in the vaccinated cohort and 724 in the non-vaccinated cohort (ratio: 1 to 4.2). The cumulative incidence of clinical outcomes among the unvaccinated vs vaccinated patients were: for hospitalization 42% (95% CI: 38.7%-46.1%) vs 29%; (95% CI: 22.4%-36.5%); for invasive mechanical ventilation requirement 8.4% (n=61) vs 4.6% (n=8) and for mortality from all causes 17% (n=123) vs 4.65% (n=8). Conclusion: In our population, unvaccinated patients with cancer have an increased risk of complications for COVID -19 infection, as hospitalization, mechanical ventilation, and mortality. It is highly recommended to actively promote the vaccination among this population. 漏 The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions