Guidelines for initiation of anti-tumour necrosis factor therapy in rheumatoid arthritis: similarities and differences across Europe.

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Learning Through Multimedia Interaction: The Construal of Primary Social Science Knowledge in Web-based Digital Learning Materials

This thesis is concerned with the construal and the recontextualisation of primary social science knowledge in hypermedia texts. More specifically, it provides an account for the relations between verbiage and image in web-based multimodal interactive leaning materials, known as Multimodal Interactives (MIs). Based on the linguistic description, the thesis offers insights into the ways in which knowledge is construed and recontextaulised in the emerging electronic multimodal discourses. The general theoretical orientation of this thesis is that of systemic functional multimodal discourse analysis (SF-MDA). Within the framework of SF-MDA, the thesis proposes a complementary perspective on intersemiosis, which treats relations between verbiage and image as patterns formed during the unfolding of a text. To capture this type of intersemiotic relations, the thesis develops a logogenetic model for SF-MDA. The defining feature the model is the temporal axis (time), which serves as the main reference point for determining semiotic units (logogenetic units) and describing semiotic patterns (logogenetic patterns). The logogenetic model is applied in studying five MIs. The basic logogenetic unit used in analysis is Critical Path, the shortest traversal through a MI. Two types of logogenetic patterns along the Critical Paths in the five MIs are examined in detail, including intersemiotic ideational coupling and clustering. There are five basic types of verbiage-imaged coupling emerged from the analysis, including Naming & Identifying, Representing, Classifying & Co-classifying, and Circumstantiating. The analysis of ideational clustering shows the different ways in which participants and activities form clusters in each MI. By analysing intersemiotic coupling and clustering, the thesis shows that language and image construe the keys notions of primary social science such as people, place and community through three fundamental principles—abstraction, generalisation and specification. The study also demonstrates the possibility of achieving different degrees of pedagogic framing in hypermedia environments

Effect van moment van vlekziektevaccinatie op het interval spenen-bronst

In de praktijk zijn er vragen over de gevolgen van vlekziektevaccinaties voor de vruchtbaarheid. Een oriënterende studie heeft aanwijzingen opgeleverd dat enten in de eerste week van de lactatie een negatieve invloed heeft op het interval spenen-bronst

Review of Program 1: Diagnostics, and Program 3: Genomics and Proteomics

Established and supported under the Australian Government’s Cooperative Research Centre Progra

Effect of methotrexate alone or in combination with sulphasalazine on the production and circulating concentrations of cytokines and their antagonists. Longitudinal evaluation in patients with rheumatoid arthritis

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Development of type 1 diabetes in a patient treated with anti-TNF-α therapy for active rheumatoid arthritis

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Identifying user preferences for a digital educational solution for young seniors with diabetes

The Eindhoven Diabetes Education Simulator project was initiated to develop an educational solution that helps diabetes patients understand and learn more about their diabetes. This article describes the identification of user preferences for the development of such solutions. Young seniors (aged 50-65 years) with type 2 diabetes were chosen as the target group because they are likely to have more affinity with digital devices than older people and because 88% of the Dutch diabetes population is > 50 years of age. Data about the target group were gathered through literature research and interviews. The literature research covered data about their device use and education preferences. To gain insight into the daily life of diabetes patients and current diabetes education processes, 20 diabetes patients and 10 medical experts were interviewed. The interviews were analyzed using affinity diagrams. Those diagrams, together with the literature data, formed the basis for two personas and corresponding customer journey maps. Literature showed that diabetes prevalence is inversely correlated to educational level. Computer and device use is relatively low within the target group, but is growing. The interviews showed that young seniors like to play board, card, and computer games, with others or alone. Family and loved ones play an important role in their lives. Medical experts are crucial in the diabetes education of young senior diabetes patients. These findings are translated into a list of design aspects that can be used for creating educational solutions

Differential virulence between Asian and African lineages of Zika virus

International audienc