Filler binder for tablets

The invention relates to a novel filler-binder for tablets, which shows a significantly reduced lubricant sensitivity when compared to prior art filler-binders. The invention further relates to a process of making said filler-binder and to the tablet obtainable by said process

Artsen en apothekers miskennen vaak een door ACE-remmers geïnduceerde prikkelhoest, wat de therapietrouw verlaagt

OBJECTIVE: A common side-effect of angiotensin-converting enzyme inhibitors (ACEi) is a persistent dry cough. Physicians and pharmacists who fail to recognise a dry cough to be ACEi-related may attempt to treat it with antitussives, instead of recommended ACEi substitution. The aim of this study was to quantify such prescription behaviour, as well as its influence on therapy compliance. DESIGN AND METHODS: Drug dispensing data were retrieved from the IADB.nl database in The Netherlands. A prescription sequence symmetry analysis was used to determine whether antitussive agents were prescribed more often following ACEi initiation than the other way around. Therapy compliance in both groups was assessed using the proportion of days covered (PDC) method; patients with a PDC ≥ 80% were considered compliant. RESULTS: 1601 patients were incident users of both ACEi and antitussives within a half-year time span. There was a significant excess of patients prescribed antitussive agents after ACEi initiation (1075 versus 526), yielding a sequence ratio of 2.0 (95% confidence interval 1.8-2.3). Therapy compliance in patients receiving antitussives after ACEi initiation was 58%, significantly lower than therapy compliance in control patients, which was 77% (

Misdiagnosis and mistreatment of ACE-inhibitor-induced cough occurs frequently and decreases therapy compliance

OBJECTIVE: A common side-effect of angiotensin-converting enzyme inhibitors (ACEi) is a persistent dry cough. Physicians and pharmacists who fail to recognise a dry cough to be ACEi-related may attempt to treat it with antitussives, instead of recommended ACEi substitution. The aim of this study was to quantify such prescription behaviour, as well as its influence on therapy compliance. DESIGN AND METHODS: Drug dispensing data were retrieved from the IADB.nl database in The Netherlands. A prescription sequence symmetry analysis was used to determine whether antitussive agents were prescribed more often following ACEi initiation than the other way around. Therapy compliance in both groups was assessed using the proportion of days covered (PDC) method; patients with a PDC ≥ 80% were considered compliant. RESULTS: 1601 patients were incident users of both ACEi and antitussives within a half-year time span. There was a significant excess of patients prescribed antitussive agents after ACEi initiation (1075 versus 526), yielding a sequence ratio of 2.0 (95% confidence interval 1.8-2.3). Therapy compliance in patients receiving antitussives after ACEi initiation was 58%, significantly lower than therapy compliance in control patients, which was 77% (

Complications of continuous intraperitoneal insulin infusion with an implantable pump

AIM: To monitor the course of continuous intraperitoneal insulin infusion (CIPII) and to gain more insight into possible complications. METHODS: A retrospective, longitudinal observational cohort study in patients with type 1 diabetes mellitus (T1DM) was performed. Only patients with "brittle" T1DM who started CIPII between January 1, 2000 and June 1, 2011, and were treated in the only centre in The Netherlands providing CIPII treatment (Isala clinics, Zwolle) were eligible for inclusion. Outcomes were defined as operation-free period (OFP), rate and type of complications. Subanalyses were made between patients starting CIPII from 2000 to 2007 and from 2007 onwards in order to study possible changes over time in complications and/or OFP. The OFP was calculated as the time from initial implantation to the date of first documented re-operation. If patients had not experienced an operation, their data were recorded at the date of last follow up or death. Kaplan-Meier curves were constructed to visualize the OFP. A (two-sided) P value of less than 0.05 was considered statistically significant. RESULTS: Fifty-seven patients were treated with CIPII, although one patient was excluded from analyses because of self-induced complications. In the remaining 56 patients, 70 complications occurred during 283 patient years. Catheter occlusion (32.9%), pump dysfunction (17.1%), pain at the pump site (15.7%) and infections (10.0%) were the most frequent complications. This resulted in a median OFP of 4.5 years (95% confidence interval 4.1-4.8 years) without any difference between the time periods. Fifty re-operations were performed because of complications, one per 5.6 patient years, with a decrease in pump dysfunction (P = 0.04) and pump explantations (P = 0.02) after 2007. In total, 9 episodes of ketoacidosis occurred during follow up and there were 69 hospital re-admissions, with a median duration of 6 d. CIPII was ceased in five patients due to recurrent infections (n = 2), pain (n = 1), inadequate glycaemic control (n = 1) or by own choice (n = 1). No CIPII related mortality was reported. CONCLUSION: The OFP has been stable over the last decade. No CIPII related mortality was reported. A significant decrease in pump dysfunction and explantation was seen after 2007 compared to the period 2000-2007. CIPII remains a safe treatment modality for specific patient groups

Tijd om te investeren in toerisme

Van Dijk, Jouke e.a. (2020). 'Tijd om te investeren in toerisme'. Opinieartikel in Dagblad van het Noorden, 30 mei 2020. ​Door de coronacrisis overwegen Nederlanders vaker dan voorheen om in Groningen op vakantie te gaan. Dat betekent dat er nu in toeristisch beleid geïnvesteerd moet worden