19 research outputs found
Beyond Schuh: early studies on the oxidation of LDL and other lipoproteins and its role in atherosclerosis
No full textPCSK9 inhibitor improves cardiac function and reduces infarct size in rats with ischaemia/reperfusion injury: Benefits beyond lipid‐lowering effects
No full textGalanin receptors activation modulates myocardial metabolic and antioxidant responses to ischaemia/reperfusion stress
No full textMalonyldialdehyde and glyoxal act differently on low-density lipoproteins and endotheliocytes
No full textMethylglyoxal May Affect Hydrogen Peroxide Accumulation in Manuka Honey Through the Inhibition of Glucose Oxidase
No full textBiodistribution of a polyethylene glycol-modified superoxide dismutase in mice and its effect on myocardial ischemia treatment in rats
No full textWe have performed a comparative study of the biodistribution in mice of native and monomethoxypolyethylene glycol-modified superoxide dismutase isolated from bovine liver after intravenous injection. Polymer modification greatly influenced the biodistribution of enzyme preparation. Monomethoxypolyethylene glycol-modified SOD (mPEG-SOD) exhibited a longer residence time and a considerably longer half-time in the blood, lungs, and heart than the native enzyme. Using a rat model of ischemia, we demonstrated that an intravenous bolus administration of mPEG-SOD reduced the size of the myocardium necrosis zone by 40% compared with a 13% reduction by native enzyme. These results suggest that mPEG-SOD is a promising agent for decreasing reperfusion injury to the cardiovascular system
Antioxidant Properties of a Pharmaceutical Substance Hypocard, a Potential Drug for Ischemic Disease
No full textNeuropsychological state of the population living in the Aral Sea region (zone of ecological crisis)
No full textEffects of consumption of edible oils for a period of 4 months on the ultrastructure of the aorta of spontaneously hypertensive rats
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