2,983 research outputs found
Duncan Jr. Named to Thorpe Award Watch List
Duncan Jr. Named to Thorpe Award Watch Lis
1992 May-October
Morehead State Athletics press releases from May to October of 1992
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A dose-ranging, parallel group, split-face, single-blind phase II study of light emitting diode-red light (LED-RL) for skin scarring prevention: study protocol for a randomized controlled trial.
BackgroundSkin fibrosis is a significant global health problem that affects over 100 million people annually and has a profoundly negative impact on quality of life. Characterized by excessive fibroblast proliferation and collagen deposition, skin fibrosis underlies a wide spectrum of dermatologic conditions ranging from pathologic scars secondary to injury (e.g., burns, surgery, trauma) to immune-mediated diseases. Effective anti-scarring therapeutics remain an unmet need, underscoring the importance of developing novel approaches to treat and prevent skin fibrosis. Our in vitro data show that light emitting diode-red light (LED-RL) can modulate key cellular and molecular processes involved in skin fibrosis. In two phase I clinical trials (STARS 1 and STARS 2), we demonstrated the safety and tolerability of LED-RL at fluences of 160 J/cm2 up to 480 J/cm2 on normal human skin.Methods/designCURES (Cutaneous Understanding of Red-light Efficacy on Scarring) is a dose-ranging, randomized, parallel group, split-face, single-blind, mock-controlled phase II study to evaluate the efficacy of LED-RL to limit post-surgical skin fibrosis in subjects undergoing elective mini-facelift surgery. Thirty subjects will be randomly allocated to three treatment groups to receive LED-RL phototherapy or temperature-matched mock irradiation (control) to either periauricular incision site at fluences of 160 J/cm2, 320 J/cm2, or 480 J/cm2. Starting one week post-surgery (postoperative days 4-8), treatments will be administered three times weekly for three consecutive weeks, followed by efficacy assessments at 30 days, 3 months, and 6 months. The primary endpoint is the difference in scar pliability between LED-RL-treated and control sites as determined by skin elasticity and induration measurements. Secondary outcomes include clinical and photographic evaluations of scars, 3D skin imaging analysis, histological and molecular analyses, and adverse events.DiscussionLED-RL is a therapeutic modality of increasing importance in dermatology, and has the potential to limit skin fibrosis clinically by decreasing dermal fibroblast activity and collagen production. The administration of LED-RL phototherapy in the early postoperative period may optimize wound healing and prevent excessive scarring. The results from this study may change the current treatment paradigm for fibrotic skin diseases and help to pioneer LED-RL as a safe, non-invasive, cost-effective, portable, at-home therapy for scars.Trial registrationClinicalTrials.gov, NCT03795116 . Registered on 20 December 2018
McGlone, Donald
Genealogy of the Donald McGlone family in Carter County, Kentucky.
Donald\u27s daughter, Mary Cesaria, was born circa 1861 and died in 1951.
The first relative that was found who was buried in Carter County was Andrew McGlone, who lived from 1746-1782.https://scholarworks.moreheadstate.edu/ccpl_genealogy/1020/thumbnail.jp
From Novelty Act to National Association: The Emergence of Ladies' Gaelic Football in the 1970s
In 1967 a county Cork farmer wrote to the Sunday Independent (Dublin) to express his hope that the Gaelic Athletic Association (G.A.A.) would ban women from attending the upcoming All-Ireland finals. The G.A.A is a male-only organisation, he argued, and the presence of women at Croke Park would take up 'valuable space'. His letter generated many outraged responses from both men and women, all arguing against his opinion and illustrating that women played a vital role within the sporting community - whether as supporters, sandwich-makers or jersey-washers. The responses highlighted how people in Ireland were reconsidering the role of women in the public sphere more generally in the late 1960s. The emergence of ladies' Gaelic football as a 'serious' sport for women in the 1970s is reflective of this changing society. Current Irish sports historiography is considerably lacking in its examination of the space women occupied in modern sport in Ireland. This piece will draw on newspapers and archival material to examine the emergence of what came to be known as ladies' Gaelic football in the late 1960s and early 1970s and to analyse the debates about the changing position of women in sport and society at this time. In so doing, this piece will aim to bring the historiography of women in Irish society in conversation with the growing historiography on sport in Ireland
An Examination of Children\u27s Active Play Imagery
The general purpose of this dissertation was to examine children’s active play imagery using Self-Determination Theory (Deci & Ryan, 2002) as a theoretical basis. The research was comprised of three studies. Study 1examined how the three types of active play imagery (i.e., fun, capability, and social) were associated with the three basic psychological needs (i.e., autonomy, competence, and relatedness). A total of 253 children aged 7-14 years old completed both the Children’s Active Play Imagery Questionnaire (Cooke et al., 2014) and the Basic Need Satisfaction in Physical Activity (Gray et al., 2009). Capability imagery was found to be positively associated with competence, social imagery was positively associated with relatedness, and fun imagery was positively associated with competence. These findings provided valuable information for Study 2.
Study 2 investigated whether a 6-week imagery intervention could increase active play levels in children 9-11 years old. The study revealed the participants in the imagery group were able to maintain their active play levels (measured by pedometers) throughout the intervention, while the control group significantly decreased their active play levels from baseline to post-intervention. These findings provided support for continuing to pursue this avenue of research and informed Study 3.
Study 3 expanded upon Study 2’s intervention by lengthening the intervention to 18 weeks, having individualized imagery scripts for the participants, and using accelerometers to measure active play. A case study was conducted with two 11 year olds. The results revealed that participant 2 was able to increase her active play levels from baseline to intervention, and maintained those levels in post-intervention. Challenges were seen in regards to wear time for participant 3; however, her subjective measure of active play followed the same pattern as participant 2. The overall findings from this dissertation established that imagery can be a promising avenue for increasing children’s active play levels
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