Peptide Elastase Inhibitors and Methods

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気管支喘息および慢性気管支炎患者における抗ヒトIgEによる好塩基球からのヒスタミン遊離

Histamine release from basophils induced by anti-IgE was studied in 8 patients with chronic bronchitis and 50 patients with bronchial asthma by analyzing doseresponse curves. As the result, there were no significant differences in maximum percent histamine release from basophils among three groups of healthy subjects (24.7± 14.2%), patients with chronic bronchitis (27.7±22.1%) and those with bronchial asthma (28.4±17.0%). In the patients with bronchial asthma, the maximum percent histamine release was higher in accordance with higher serum IgE levels, and low maximum percent release was observed in patients with intrinsic asthma (14.1±7.2%). Study of dose-response curves of anti-IgE-induced histamine release showed that a negative slope from E(2) to E(1) was observed in both healthy subjects and patients with chronic bronchitis. The majority of asthmatics with serum IgE levels of 501IU/ml or over showed a positive slope from E(2) to E(1).気管支喘息50例，慢性気管支炎8例を対象に，抗ヒトIgE添加時の好塩基球からのヒスタミン遊離を全血法により行ない，その臨床的評価について検討を加えた。抗ヒトIgE海底時のMax　％　histamine releaseの平均は，健康人24.7±14.2％，慢性気管支炎27.7±22.1％，気管支喘息28.4±17.0％であり，3者間に有意の差はみられなかった。すなわち，抗ヒトIgE添加により健康人や慢性気管支炎患者の好塩基球からも有意のヒスタミン遊離が見られた。気管支喘息のなかでは，内因性喘息症例においてヒスタミン遊離（14.1±7.2％）の低い傾向が見られた。Dose-response curveの検討では，健康人，慢性気管支炎症例では全例E（2）からE（1）へかけてのnegative slopeを示した。気管支喘息症例では，血清IgE値500IU/ml以下の症例ではnegative slopeを示す症例が多く，一方501IU/ml以上の症例ではpositive slopeを示す症例がより多く見られた

Increased mast cells in endocervical smears of women with dysmenorrhea.

Background: Mast cells are observed in peritoneal endometriosis which causes dysmenorrhea. However, there is no report about the relationship between endocervical mast cells and dysmenorrhea. The aim of this study is to evaluate the relationship using endocervical smears.Materials and Methods: Between January 2016 and June 2016, patients filled out a questionnaire regarding dysmenorrhea and were classified into the dysmenorrhea or the control group (without dysmenorrhea). Patients underwent endocervical brushing and endocervical smears were obtained. The smears were stained with methylene blue to detect mast cells. The number of mast cells per slide was counted by microscopy and recorded. Results:Eighty-nine patients were enrolled in this study (dysmenorrhea group, 34; control group, 55). The median number of mast cells present in the endocervical one slides was 35 (interquartile range, 17–58) and 2 (interquartile range, 0–6) in the dysmenorrhea and control groups, respectively. There was a significant difference in the number of mast cells between the two groups (P < 0.0001). Conclusion: More mast cells were observed in the endocervical smears of women with dysmenorrhea than in those of women without dysmenorrhea

Hydrodynamic-Pressure-Induced Elastic Deformation of Thrust Slide-Bearings in Scroll Compressors and Oil Film Pressure Increase Due to Oil Envelopment

This paper presents the concept of the Elasto-Hydrodynamic Lubrication?EHL?of thrust slide-bearings in scroll compressors, resulting in the superior lubrication characteristics of these bearings. The thrust plate undergoes elastic deformation due to axial loading, resulting in the formation of a uniform fluid wedge between the orbiting and fixed thrust plates. This wedge region has very high induced oil film pressure, which explains the remarkably good lubrication characteristics of the thrust slide-bearing. Furthermore, the high oil film pressure induces further local elastic deformation of the thrust plate, forming an EHL oil pocket with the thrust plate and a further increase in the oil film pressure between the sliding surfaces due to this oil envelopment. The formation of the EHL pocket was confirmed using FEM analysis and lubrication tests on the elastic deformation of the thrust plate. Subsequently, the additional increase in oil film pressure, due to the EHL pocket effect, was examined in computer simulations applying the average Reynolds equation for the boundary of elastic deformation of the thrust plate. In these studies, a 6.7% increase in oil film pressure was ascertained for a small cooling capacity scroll compressor driven at 3600 rpm with 0.1 kW motor. The oil envelopment contributes to the superior lubrication performance of the thrust slide bearings scroll compressors