The nature of the ISM in galaxies during the star-formation activity peak of the Universe

We combine a semi-analytic model of galaxy formation, tracking atomic and molecular phases of cold gas, with a three-dimensional radiative-transfer and line tracing code to study the sub-mm emission from atomic and molecular species (CO, HCN, [CI], [CII], [OI]) in galaxies. We compare the physics that drives the formation of stars at the epoch of peak star formation (SF) in the Universe (z = 2.0) with that in local galaxies. We find that normal star-forming galaxies at high redshift have much higher CO-excitation peaks than their local counterparts and that CO cooling takes place at higher excitation levels. CO line ratios increase with redshift as a function of galaxy star-formation rate, but are well correlated with H2 surface density independent of redshift. We find an increase in the [OI]/[CII] line ratio in typical star-forming galaxies at z = 1.2 and z = 2.0 with respect to counterparts at z = 0. Our model results suggest that typical star-forming galaxies at high redshift consist of much denser and warmer star-forming clouds than their local counterparts. Galaxies belonging to the tail of the SF activity peak at z = 1.2 are already less dense and cooler than counterparts during the actual peak of SF activity (z = 2.0). We use our results to discuss how future ALMA surveys can best confront our predictions and constrain models of galaxy formation.Comment: 19 pages, 14 figures, accepted for publication in MNRA

Hierarchical Bayesian inference of the Initial Mass Function in Composite Stellar Populations

The initial mass function (IMF) is a key ingredient in many studies of galaxy formation and evolution. Although the IMF is often assumed to be universal, there is continuing evidence that it is not universal. Spectroscopic studies that derive the IMF of the unresolved stellar populations of a galaxy often assume that this spectrum can be described by a single stellar population (SSP). To alleviate these limitations, in this paper we have developed a unique hierarchical Bayesian framework for modelling composite stellar populations (CSPs). Within this framework we use a parameterized IMF prior to regulate a direct inference of the IMF. We use this new framework to determine the number of SSPs that is required to fit a set of realistic CSP mock spectra. The CSP mock spectra that we use are based on semi-analytic models and have an IMF that varies as a function of stellar velocity dispersion of the galaxy. Our results suggest that using a single SSP biases the determination of the IMF slope to a higher value than the true slope, although the trend with stellar velocity dispersion is overall recovered. If we include more SSPs in the fit, the Bayesian evidence increases significantly and the inferred IMF slopes of our mock spectra converge, within the errors, to their true values. Most of the bias is already removed by using two SSPs instead of one. We show that we can reconstruct the variable IMF of our mock spectra for signal-to-noise ratios exceeding $\sim$75.Comment: Accepted for publication in MNRAS, 16 pages, 8 figure

Rest-frame ultra-violet spectra of massive galaxies at z=3: evidence of high-velocity outflows

Galaxy formation models invoke the presence of strong feedback mechanisms that regulate the growth of massive galaxies at high redshifts. In this paper we aim to: (1) confirm spectroscopically the redshifts of a sample of massive galaxies selected with photometric redshifts z > 2.5; (2) investigate the properties of their stellar and interstellar media; (3) detect the presence of outflows, and measure their velocities. To achieve this, we analysed deep, high-resolution (R~2000) FORS2 rest-frame UV spectra for 11 targets. We confirmed that 9 out of 11 have spectroscopic redshifts z > 2.5. We also serendipitously found two mask fillers at redshift z > 2.5, which originally were assigned photometric redshifts 2.0 < z < 2.5. In the four highest-quality spectra we derived outflow velocities by fitting the absorption line profiles with models including multiple dynamical components. We found strongly asymmetric, high-ionisation lines, from which we derived outflow velocities ranging from 480 to 1518 km/s. The two galaxies with highest velocity show signs of AGN. We revised the spectral energy distribution fitting U-band through 8 micron photometry, including the analysis of a power-law component subtraction to identify the possible presence of active galactic nuclei (AGN). The revised stellar masses of all but one of our targets are >1e10 Msun, with four having stellar masses > 5e10 Msun. Three galaxies have a significant power-law component in their spectral energy distributions, which indicates that they host AGN. We conclude that massive galaxies are characterised by significantly higher velocity outflows than the typical Lyman break galaxies at z ~ 3. The incidence of high-velocity outflows (~40% within our sample) is also much higher than among massive galaxies at z < 1, which is consistent with the powerful star formation and nuclear activity that most massive galaxies display at z > 2.Comment: 17 pages, 14 figures, Accepted for publication in A&

SpaceOAR to improve dosimetric outcomes for monotherapy high-dose-rate prostate implantation in a patient with ulcerative colitis.

High-dose-rate (HDR) brachytherapy is an attractive option for patients receiving definitive radiation therapy for prostate cancer with decreased overall dose to the pelvis. However, ulcerative colitis increases rectal toxicity risk and may be a contraindication. A synthetic hydrogel, SpaceOAR (Augmentix Inc., Waltham, MA, USA), can facilitate the use of HDR brachytherapy for patients where rectal toxicity is a limiting factor. SpaceOAR gel (13.19 cc) was utilized in a monotherapy HDR prostate treatment with Ir-192 under transrectal ultrasound guidance, with the intention of decreasing rectal dose. SpaceOAR gel was inserted transperineally into the patient 18 days prior to the procedure. The HDR brachytherapy procedure was tolerated without incident. All planning constraints were met, and the following dosimetry was achieved: Prostate – V100% = 97.3%, V150% = 35%, V200% = 14.5%; Urethra – V118% = 0%; Rectum – D2 cc = 51.6%, V75% = 0 cc. The rectum-catheter spacing was on average between 6-8 mm. Average spacing for our 10 most recent patients without SpaceOAR was 3 mm. SpaceOAR did not hinder or distort ultrasound imaging or increase treatment time. SpaceOAR successfully increases catheter-rectal wall spacing and decreases rectal dose due to improved planning capabilities, while decreasing the likelihood of rectal perforation. One application of this tool is presented to mitigate potential toxicities associated with ulcerative colitis. At five months, one week, and one day follow-up, the patient reported no bowel issues following HDR brachytherapy. © 2018 Termedia Publishing House Ltd. All Rights Reserved