Measurement of the Bottom-Strange Meson Mixing Phase in the Full CDF Data Set

We report a measurement of the bottom-strange meson mixing phase \beta_s using the time evolution of B0_s -> J/\psi (->\mu+\mu-) \phi (-> K+ K-) decays in which the quark-flavor content of the bottom-strange meson is identified at production. This measurement uses the full data set of proton-antiproton collisions at sqrt(s)= 1.96 TeV collected by the Collider Detector experiment at the Fermilab Tevatron, corresponding to 9.6 fb-1 of integrated luminosity. We report confidence regions in the two-dimensional space of \beta_s and the B0_s decay-width difference \Delta\Gamma_s, and measure \beta_s in [-\pi/2, -1.51] U [-0.06, 0.30] U [1.26, \pi/2] at the 68% confidence level, in agreement with the standard model expectation. Assuming the standard model value of \beta_s, we also determine \Delta\Gamma_s = 0.068 +- 0.026 (stat) +- 0.009 (syst) ps-1 and the mean B0_s lifetime, \tau_s = 1.528 +- 0.019 (stat) +- 0.009 (syst) ps, which are consistent and competitive with determinations by other experiments.Comment: 8 pages, 2 figures, Phys. Rev. Lett 109, 171802 (2012

Cell surface and molecular expression of immunoregulatory determinants on B-cell chronic lymphocytic leukaemia cells and their putative normal lineage counterparts

SIGLEAvailable from British Library Document Supply Centre- DSC:DX180379 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Official statistics and economic governance in interwar Germany

SIGLEAvailable from British Library Document Supply Centre-DSC:DXN008983 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

The Cutting Edge of Modernity: Machine Tools in the United States and Germany 1930-1945

This paper aims to examine the difference between US and European manufacturing before and during the World War II, focusing on the key technology in the metal-working sector: machine tools. We present a new data set covering the installed capacity of metal-working tools in the United States and Germany for the period 1930-1945. The existing literature is heavily dependent on assumptions about the different type of machine tools in use on either side of the Atlantic. So far, systematic comparison has been limited to case studies. This is the first attempt to quantify the differences in this key technology for the entirety of metal-working in both economies. The enormous detail of the statistical sources we have uncovered allows us to combine aggregation and a degree of specificity, which exceeds that of any previous case study. In the German case, the original data is divided into well over a hundred sub-categories. For comparative purposes, we have identified 19 major classes of machines, which aggregate over 50 sub-categories. Our results suggest the need for a far more nuanced understanding of metal-working than the dichotomous picture of American mass manufacture, reliant on special-purpose tools, and European craft manufacturing employing general-purpose machinery. For 1930, we find a remarkable similarity in machine to worker ratios between Germany and the United States. There are differences in certain key areas. However, the US stock of metal-working tools is not yet distinguished by a clear commitment to mass production technology. For the period after 1935, until the early 1940s, our data suggest a remarkable degree of convergence. The American stock stagnated. In some areas, there was disinvestment. And the average age of machinery rose dramatically. By contrast, Germany entered a period of rapid catch-up, which appears to have continued into the early years of the war. By 1940, German metal-working came close to matching its American counterpart in terms of the number of workers employed and the quantity and types of machines installed. German machines were, on average, far younger. This process of catching-up, however, was dramatically reversed during World War II. Over a period of no more than four years the American stock expanded by over eighty percent and growth was markedly concentrated in key categories of mass production equipment. It appears that it was only in this period that mass production machinery came to truly dominate US metal-working. German investment, albeit moving in the same direction, failed to match the new intensity of American commitment to mass production in some key machinery classesMachine tools, Metal working. US, Germany, Production technology, WW2

Association between 25-Hydroxyvitamin D and Metabolic Syndrome in Older Adults: The Health, Aging and Body Composition Study

Objective. Low 25-hydroxyvitamin D (25[OH]D) levels and metabolic syndrome (MetS) are prevalent among older adults; however, longitudinal studies examining 25(OH)D status and MetS are lacking. We explore the association of 25(OH)D levels with prevalent and incident MetS in white and black older adults. Research Design and Methods. A total of 1620 white and 1016 black participants aged 70-79 years from the Health ABC cohort with measured 25(OH)D levels and data on MetS and covariates of interest were examined. The association between 25(OH)D levels and prevalent MetS at baseline and incident MetS at 6-year follow-up was examined in whites and blacks separately using logistic regression adjusting for demographics, lifestyle factors, and renal function. Results. At baseline, 635 (39%) white and 363 (36%) black participants had prevalent MetS. In whites, low 25(OH) D levels were associated with prevalent MetS (adjusted OR (95% CI), 1.85 (1.47, 2.34)) and 1.96 (1.46, 2.63) for 25(OH)D of 20-<30 and <20 vs. >= 30 ng/ml, respectively). The association was attenuated after adjustment for BMI but remained significant. No association was found between 25(OH)D levels and prevalent MetS in blacks. Among those without MetS at baseline (765 whites, 427 blacks), 150 (20%) whites and 87 (20%) blacks had developed MetS at 6-year follow-up. However, 25(OH)D levels were not associated with incident MetS in whites or blacks. Conclusion. In older adults, low 25(OH)D levels were associated with increased odds of prevalent MetS in whites but not in blacks. No association was observed between 25(OH)D levels and incident MetS in either whites or blacks

Selective and Signal-dependent Recruitment of Membrane Proteins to Secretory Granules Formed by Heterologously Expressed von Willebrand Factor

von Willebrand factor (vWF) is a large, multimeric protein secreted by endothelial cells and involved in hemostasis. When expressed in AtT-20 cells, vWF leads to the de novo formation of cigar-shaped organelles similar in appearance to the Weibel-Palade bodies of endothelial cells in which vWF is normally stored before regulated secretion. The membranes of this vWF-induced organelle, termed the pseudogranule, are uncharacterized. We have examined the ability of these pseudogranules, which we show are secretagogue responsive, to recruit membrane proteins. Coexpression experiments show that the Weibel-Palade body proteins P-selectin and CD63, as well as the secretory organelle membrane proteins vesicle-associated membrane protein-2 and synaptotagmin I are diverted away from the endogenous adrenocorticotropic hormone-containing secretory granules to the vWF-containing pseudogranules. However, transferrin receptor, lysosomal-associated membrane protein 1, and sialyl transferase are not recruited. The recruitment of P-selectin is dependent on a tyrosine-based motif within its cytoplasmic domain. Our data show that vWF pseudogranules specifically recruit a subset of membrane proteins, and that in a process explicitly driven by the pseudogranule content (i.e., vWF), the active recruitment of at least one component of the pseudogranule membrane (i.e., P-selectin) is dependent on residues of P-selectin that are cytosolic and therefore unable to directly interact with vWF

Under-Reporting of energy intake in elderly Australian women is associated with a higher body mass index

Design: Dietary intake was assessed using a 3-day weighed food record. Protein intake was validated by 24-hour urinary nitrogen. To examine under-reporting, participants were grouped according to their energy intake and compared to the Goldberg cut-off equation. Logistic regression was performed to assess the influence of body mass index (BMI) and social-demographic factors on under-reporting. Setting: Community dwelling elderly women from Perth, Western Australia. Participants: 217 elderly women aged 70–80 years. Results: Under-reporters had a higher physical activity level (p<0.001) compared with acceptable-reporters. The under-reporters also had a higher body weight (p=0.006), body mass index (BMI) (p=0.001), waist (p=0.011), hip circumference (p<0.001), whole body fat mass (p<0.001) and percentage body fat (p<0.001) than acceptable-reporters. Under-reporters had a significantly lower intakes of protein, fat, carbohydrate and alcohol (p<0.001) and fewer reported food items, compared with acceptable reporters. However, 24-hour urinary nitrogen was only marginally different between the two groups (p=0.053). Participants with a higher BMI were more likely to under-report their energy intake (BMI=25–29.9: odds ratio=2.98[95% CI=1.46–6.09]; BMI≥30: 5.84[2.41–14.14]). Conclusion: Under-reporting energy intake in elderly women was associated with a higher BMI, body fat and higher self-reported physical activity levels. A higher BMI (≥25) appears to be most significant factor in determining if elderly women will underreport their food intake and may be related to body image. These results have implications for undertaking surveys of food intake in elderly women