THE EFFECT OF INTEGRATED WEED MANAGEMENT STRATEGIES ON WEED POPULATIONS AND BIOMASS, PASTURE PRODUCTIVITY, ECONOMIC RETURNS, AND FORAGE QUALITY WITH AND WITHOUT GRAZING

Field studies examined the strategies of mowing, herbicide, fertility, and all combinations on tall ironweed populations, weed biomass, pasture yield, grazing, economics, and forage quality at three Kentucky locations. Mowing was performed in July 2008 and 2009, herbicide applied in August 2008, and fertilizer applied in September 2008 and 2009 at all locations. Weed populations were measured in 2008, 2009, and 2010, and forage and weed biomass collected in May or June of 2009 and 2010. Herbicide treatments reduced weed biomass at all locations, and reduced tall ironweed stems by 64% or greater in 2009 at all locations. Weed biomass did not differ when comparing all treatments with and without mowing or treatments with or without fertilizer. Forage grass biomass produced was greatest with herbicide plus fertilizer and with the combination of mowing plus herbicide plus fertilizer at all locations in both years. Two years of grazing did not reduce weed populations. Grazing did reduce forage grass and clover biomass at one location, and weed biomass at two locations. Two locations had positive economic returns based on herbicide treatment for weed control and forge yield. Herbicide treatments reduced crude protein at one location and in-vitro true digestibility at two locations

Integrating Weed Management Practices to Enhance Productivity of Grazed Pastures

As animal grazing has intensified within Kentucky and the surrounding region problematic weeds such as tall ironweed, spiny amaranth, horsenettle, buttercup, common cocklebur, and thistles have been increasing. These weeds become prominent in pastures because they have spines, thorns, or are unpalatable to animals. Animals selectively graze and avoid these weedy plants and with intensive grazing practices their populations are allowed to increase. Livestock producers are seeking ways to increase pasture productivity by minimizing the impact of these and other weeds on grazed lands

Stratified analyses refine association between TLR7 rare variants and severe COVID-19

Summary: Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited. Here, 52 genes with prior etiological evidence were sequenced in 1,772 severe COVID-19 cases and 5,347 population-based controls from Spain/Italy. Rare deleterious TLR7 variants were present in 2.4% of young (<60 years) cases with no reported clinical risk factors (n = 378), compared to 0.24% of controls (odds ratio [OR] = 12.3, p = 1.27 × 10−10). Incorporation of the results of either functional assays or protein modeling led to a pronounced increase in effect size (ORmax = 46.5, p = 1.74 × 10−15). Association signals for the X-chromosomal gene TLR7 were also detected in the female-only subgroup, suggesting the existence of additional mechanisms beyond X-linked recessive inheritance in males. Additionally, supporting evidence was generated for a contribution to severe COVID-19 of the previously implicated genes IFNAR2, IFIH1, and TBK1. Our results refine the genetic contribution of rare TLR7 variants to severe COVID-19 and strengthen evidence for the etiological relevance of genes in the interferon signaling pathway