Biochemical Changes in Whole Blood - Effect of Storage

Background: Storage of whole blood has deleterious effects on the biochemical parameters of RBCs. Aim: To study the changes in biochemical parameters in whole blood upon storage. Materials and Methods: 30 healthy donors were included in this study and effect of storing whole blood was studied on day 0, 3, 7, 14 and 21. Results: Highly significant changes were noted in the levels of blood pH, sodium, potassium, chloride, bicarbonate, aspartate transaminase and lactate dehydrogenase. Conclusion: There are significant changes in the biochemical parameters during storage. The most significant change is the marked increase in potassium levels. In order to reduce the deleterious effects of stored blood in the recipient, it is advisable to check the clinical details of the patient. Care should be taken to issue fresh blood (not more than 7 days old) particularly to patients with renal disorders.