Methods to enhance content distribution for very large scale online communities

The Internet has experienced an exponential growth in the last years, and its number of users far from decay keeps on growing. Popular Web 2.0 services such as Facebook, YouTube or Twitter among others sum millions of users and employ vast infrastructures deployed worldwide. The size of these infrastructures is getting huge in order to support such a massive number of users. This increment of the infrastructure size has brought new problems regarding scalability, power consumption, cooling, hardware lifetime, underutilization, investment recovery, etc. Owning this kind of infrastructures is not always affordable nor convenient. This could be a major handicap for starting projects with a humble budget whose success is based on reaching a large audience. However, current technologies might permit to deploy vast infrastructures reducing their cost. We refer to peer-to-peer networks and cloud computing. Peer-to-peer systems permit users to yield their own resources to distributed infrastructures. These systems have demonstrated to be a valuable choice capable of distributing vast amounts of data to large audiences with a minimal starting infrastructure. Nevertheless, aspects such as content availability cannot be controlled in these systems, whereas classic server infrastructures can improve this aspect. In the recent time, the cloud has been revealed as a promising paradigm for hosting horizontally scalable Web systems. The cloud offers elastic capabilities that permit to save costs by adapting the number of resources to the incoming demand. Additionally, the cloud makes accessible a vast amount of resources that may be employed on peak workloads. However, how to determine the amount of resources to use remains a challenge. In this thesis, we describe a hierarchical architecture that combines both: peer-to-peer and elastic server infrastructures in order to enhance content distribution. The peer-topeer infrastructure brings a scalable solution that reduces the workload in the servers, while the server infrastructure assures availability and reduces costs varying its size when necessary. We propose a distributed collaborative caching infrastructure that employs a clusterbased locality-aware self-organizing P2P system. This system, leverages collaborative data classification in order to improve content locality. Our evaluation demonstrates that incrementing data locality permits to improve data search while reducing traffic. We explore the utilization of elastic server infrastructures addressing three issues: system sizing, data grouping and content distribution. We propose novel multi-model techniques for hierarchical workload prediction. These predictions are employed to determine the system size and request distribution policies. Additionally, we propose novel techniques for adaptive control that permit to identify inaccurate models and redefine them. Our evaluation using traces extracted from real systems indicate that the utilization of a hierarchy of multiple models increases prediction accuracy. This hierarchy in conjunction with our adaptive control techniques increments the accuracy during unexpected workload variations. Finally, we demonstrate that locality-aware request distribution policies can take advantage of prediction models to adequate content distribution independently of the system size

NESS. Sistema de recirculación de agua caliente sin ramal adicional de retorno. Ahorro de agua y energía

El objetivo del presente estudio es identificar las diferencias existentes entre el sistema de aprovechamiento de agua basado en el doble ramal de agua caliente y una innovadora alternativa que realiza la recirculación sin la necesidad de un ramal de retorno adicional, empleando la instalación convencional de cualquier vivienda. Para ello, se realizará un detallado análisis del consumo de energía y económico proporcionado por la ya conocida red de retorno con doble ramal de agua caliente, para posteriormente compararlo con el sistema de recirculación sin ramal adicional de retorno. Atendiendo a los datos arrojados por esta comparación, se presentan las ventajas e inconvenientes de un sistema respecto al otro, y por tanto, cuál es considerado óptimo en cada caso.Consejo General de la Arquitectura Técnica de Españ

EducaFarma 3.0. Continuación y mejora de un programa de formación continuada de profesores y alumnos de la Facultad de Farmacia con recursos propios

Memoria ID-0186. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2014-2015

Influence of non-osteoporotic treatments in patients on active anti-osteoporotic therapy: evidence from the OSTEOMED registry

Producción CientíficaPurpose To evaluate the effect of different non-osteoporotic drugs on the increase or decrease in the risk of incident fragility fractures (vertebral, humerus or hip) in a cohort of patients diagnosed with osteoporosis on active anti-osteoporotic therapy. Methods For this retrospective longitudinal study, baseline and follow-up data on prescribed non-osteoporotic treatments and the occurrence of vertebral, humerus or hip fractures in 993 patients from the OSTEOMED registry were analyzed using logistic regression models. The drugs evaluated with a possible beneficial effect were thiazides and statins, while the drugs evaluated with a possible harmful effect were antiandrogens, aromatase inhibitors, proton pump inhibitors, selective serotonin reuptake inhibitors, benzodiazepines, GnRH agonists, thyroid hormones, and oral and inhaled corticosteroids. Results Logistic regression analyses indicated that no treatment significantly improved fracture risk, with the only treatments that significantly worsened fracture risk being letrozole (OR = 0.18, p-value = 0.03) and oral corticosteroids at doses ≤ 5 mg/ day (OR = 0.16, p-value = 0.03) and > 5 mg/day (OR = 0.27, p-value = 0.04). Conclusion The potential beneficial or detrimental effects of the different drugs evaluated on fracture risk are masked by treatment with anabolic or antiresorptive drugs that have a more potent action on bone metabolism, with two exceptions: letrozole and oral corticosteroids. These findings may have important clinical implications, as patients receiving these treat- ments are not fully protected by bisphosphonates, which may imply the need for more potent anti-osteoporotic drugs such as denosumab or teriparatide.Publicación en abierto financiada por el Consorcio de Bibliotecas Universitarias de Castilla y León (BUCLE), con cargo al Programa Operativo 2014ES16RFOP009 FEDER 2014-2020 DE CASTILLA Y LEÓN, Actuación:20007-CL - Apoyo Consorcio BUCL

El proceso penal del siglo XXI, Quo vadis iustitia?

Actas de la Jornada "EL PROCESO PENAL DEL SIGLO XXI: QUO VADIS IUSTITIA?", celebrada en la Facultad de Derecho de Jerez de la Frontera, de la Universidad de Cádiz, el 24 de Abril de 2015.Quo vadis iustitia? La pregunta persigue que tanta reforma como se persigue se detenga un momento para responder y, con ello, para pensar sobre el modelo de justicia que se está diseñando. Ya han sido muchas las voces que han hablado de la legislación “galopante” o “motorizada”, o que han usado variados calificativos para referirse al frenesí en la productividad de nuestras cámaras legislativas. Si esto es algo que puede llegar a provocar inseguridad jurídica, debemos pensar que, cuando de lo que se trata es de las normas que afectan a la justicia (orgánicas y procesales) lo que se puede llegar a provocar es una alteración en el equilibrio de los poderes del Estado. No se puede dejar de lado que el funcionamiento de la justicia tiene que ver con uno de los poderes del Estado, el cual, precisamente, debe constituir el fiel que refleje el equilibrio entre los demás, aunque Montesquieu ya no esté muy de moda. La jornada s centra en algunos aspectos de la reforma del proceso penal.Área de Derecho Procesal, Facultad de Derecho Universidad de Cádiz Casa de Iberoamérica (Ayunatmiento de Cádiz) Gestiona: FUECA Proyecto Investigación MINECO DER 2011-26954Documento PDF con 232 páginas

EducaFarma 4.0

Memoria ID-0264. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2015-2016

Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism

Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.info:eu-repo/semantics/publishedVersio

Spread of a SARS-CoV-2 variant through Europe in the summer of 2020

[EN] Following its emergence in late 2019, the spread of SARS-CoV-21,2 has been tracked by phylogenetic analysis of viral genome sequences in unprecedented detail3,4,5. Although the virus spread globally in early 2020 before borders closed, intercontinental travel has since been greatly reduced. However, travel within Europe resumed in the summer of 2020. Here we report on a SARS-CoV-2 variant, 20E (EU1), that was identified in Spain in early summer 2020 and subsequently spread across Europe. We find no evidence that this variant has increased transmissibility, but instead demonstrate how rising incidence in Spain, resumption of travel, and lack of effective screening and containment may explain the variant’s success. Despite travel restrictions, we estimate that 20E (EU1) was introduced hundreds of times to European countries by summertime travellers, which is likely to have undermined local efforts to minimize infection with SARS-CoV-2. Our results illustrate how a variant can rapidly become dominant even in the absence of a substantial transmission advantage in favourable epidemiological settings. Genomic surveillance is critical for understanding how travel can affect transmission of SARS-CoV-2, and thus for informing future containment strategies as travel resumes.S

¿Qué queda de mí?

Este libro es una reclamación a quienes hemos sido, somos o seremos docentes. A quienes no hemos respetado a las personas que se han puesto junto a nosotros y nosotras, confiando su bien más preciado: la libertad. Estas páginas denuncian cada vez que convertimos una visión en la visión, una emoción en la emoción, un saber en el saber, un comportamiento en el comportamiento. Es un grito contra la imposición, la normalización, la neutralización y la universalización de una perspectiva particular. Una pugna contra cada proceso que no se ha conectado con las vidas de los aprendices. Un texto colaborativo realizado por alumnado de Educación y Cambio Social en el Grado en Educación Infantil de la Universidad de Málaga y coordinado por Ignacio Calderón Almendros