AUTOANTIBODIES CONTENTS OF TEENAGERS WITH CHRONIC DISEASES OF THE UPPER RESPIRATORY TRACT LIVING IN THE INDUSTRIAL CENTRE

Environmental conditions may be a prerequisite for the development of various pathological processes in individuals living in environmentally disadvantaged areas. The respiratory system is the first target of the pollutants. Therefore, respiratory diseases occupy the first place in the overall morbidity. The aim of this work was to study the content of autoantibodies in blood serum of teenagers with chronic disease of the upper respiratory tract, living in air pollution emissions of the petrochemical industry. Teenagers from industrial center living near petrochemical company and "sleeping areas" were examined. Otolaryngologist conducted a survey to assess the state of the upper respiratory tract (URT). In each of the areas individuals with and without chronic diseases of the URT were isolated. The content of IgG antibodies in the serum to antigens that characterizes the general state of the immune system (the native DNA, p2-glycoprotein I, Fc-fragment of IgG) was studied by enzyme immunoassay. Statistical processing of the results was performed using nonparametric methods software package «Statistica 6.0». Diseases of the respiratory system take the first place (42.9 %) in the structure of morbidity level. According to anamnestic data more often were the following disorders: chronic tonsillitis (18,9 ± 2,6 %), chronic pharyngitis (6,8 ± 1,7 %), acute respiratory infections (42,3 ± 3,32 %). Comparison of the incidence of chronic diseases of the upper respiratory tract infections in teenagers found that cases of chronic tonsillitis were observed in 45,0 ± 4,9 % of schoolchildren living near the industrial plant and 33,3 ± 4,3 % of teenagers from residential areas, cases of chronic pharyngitis - in 12,7± 3,3 % and5± 1,9 %, respectively. In teenagers from the «sleeping areas» with chronic diseases of the URT the level of auto-antibodies to p2-glycoprotein I was lower than one in healthy children from the same area due to the greater number of cases of lower values. In the group of teenagers with chronic diseases of the URTfrom environmentally disadvantaged areas children with high content of antibodies to p2-glycoprotein I were more common than in the groups of healthy teenagers living in the same area. The findings suggest that there is activation of the immune system in healthy schoolchildren living in a «sleeping areas" of the industrial city. It can be assumed that the detected changes in the content of autoantibodies may indicate features for the adaptive processes under development pressure because of the surveyed students identified isolated cases of hypo- or hyperimmunoreactivity of specific autoantibodies

Content of autoantibodies in teenagers with chronic pathology of upper respiratory tract who live in an industrial center

Conditions of environment can become causes of developments of different pathologic processes in people, living in ecologically unfavorable regions. The aim. of the work was to study contents of autoantibodies in blood serum of teenagers with chronic pathology of respiratory tract living in areas contaminated with emissions of petrochemical industry. We examined teenagers living near petrochemical industry and. in commuter towns. In each area people with and. without chronic pathology of respiratory tract were marked out. We studied the levels of serum autoantibodies to antigens that characterize condition of immune system. (nDNA, β2-glycoprotein I, Fc-enzyme, IgG). The changes of autoantibodies contents can tell about peculiarities of course of adaptive processes in teenagers living in the conditions of technogenic load

Electrocatalytic determination of oxalate ions on chemically modified electrodes

The electrocatalytic activity with respect to oxalate ions of spongy osmium immobilized within a carbon-paste electrode was studied. A procedure is proposed for electrocatalytic determination of oxalate ions on a chemically modified electrode based on spongy osmium under conditions of flow-through-injection analysis. © 2001 MAIK "Nauka/Interperiodica"

DEGREE ASSESSMENT OF POLLUTION AND PATHOLOGY OF UPPER RESPIRATORY TRACT IN TEENAGERS OF URBANIZED TERRITORIES OF IRKUTSK REGION

This study aimed to reveal air pollution and its influence on pathology of upper respiratory tract in teenagers of Angarsk and Sayansk. The quantitative content of chemical substances in the atmospheric air of the celitebic territory of Angarsk and Sayansk was studied based on the data of the hydro-meteorological center, the content of chemical substances in indoor air was assessed based on studying of the educational institutions. Two territories with a different pollution level were chosen to investigate in Angarsk. The higher summary risk of forming the respiratory organ pathology stipulated by the indoor air pollution and the atmospheric air with the tropic substances to the systems indicated was revealed to be in the schoolchildren in Angarsk. The studies performed in the educational school rooms have shown that on the whole the largest pollution degree was induced by the suspended substances. In the educational school rooms studied in Angarsk the increase in the hygienic normative on suspended substances was found to be in the educational classes in 43 % of samples, in the computer classes and in the sporting halls - in 44 % of samples. Sometimes the increase in the limited allowed concentration (LAC) was more than 2 times. The increase in the LAC of formaldehyde was observed to be in 13 % of samples in the educational classes. In the incidence structure according to applying for medical assistance the respiratory organ diseases were found to occupy the first place, at the same time the pathology of the upper respiratory ways prevailed in both towns. The chronic glandular and adenoid diseases as well as the allergic rhinitis were more often revealed. In comparison of the regions in Angarsk which are different in the pollution levels, it was found that the chronic pathology of the upper respiratory ways occurred 1,4 times more often in first region than in second one and 2,8 times more often than in Sayansk

Thyroid status of males with acute infectious pulmonary destruction

The aim of the study was to investigate the indicators of the thyroid status in males with acute infectious pulmonary destruction (AIPD), depending on the disease form and the presence of complications. Material and methods. The serum levels of total triiodothyronine (T3), total thyroxine (T4) and thyroid-stimulating hormone (TSH) were measured by radioimmunoassay in 80 males with AIPD and 30 healthy males volunteers. Results. T3 serum level is decreased in males with AIPD and is not depended on the disease form and complications. T3 serum level reduction is occurred due to decrease of peripheral conversion of thyroid hormones. If AIPD is complicated by sepsis, then T4 production is reduced. T4 serum level correlates with the presence of sepsis in males with AIPD (rS = –0.49; p = 0.000003). The sepsis probability threshold in males with AIPD for value T4 is ≤95.5 nmol/L with a sensitivity of 100 % and a specificity of 62.5 %. Thyroid function remains normal in 25 % (95 % CI: 16–34) of males with AIPD, in other cases it is represented by: primary hypothyroidism – in 11 % (95 % CI: 4–18), nonthyroidal illness syndrome (NTIS) type I – in 44 % (95 % CI: 33–55), NTIS type II – in 11 % (95 % CI: 4–18), NTIS type V – in 9 % (95 % CI: 3–15). NTIS type II is associated with the highest mortality rate (pFisher = 0.0015). T4 serum levels correlate with mortality in males with AIPD (rS = –0.37; p = 0.00082). The mortality probability threshold in males with AIPD for value T4 is ≤70.1 nmol/L with a sensitivity of 68.7 % and a specificity of 78.1 %. The obtained data indicates the advisability of monitoring and analysis of the thyroid status indicators in males with AIPD for the diagnosis of sepsis and prognosis of the disease outcome

Observation of narrow baryon resonance decaying into pKs0pK^0_s in pA-interactions at 70GeV/c70 GeV/c with SVD-2 setup

SVD-2 experiment data have been analyzed to search for an exotic baryon state, the $\Theta^+$-baryon, in a $pK^0_s$ decay mode at $70 GeV/c$ on IHEP accelerator. The reaction $pA \to pK^0_s+X$ with a limited multiplicity was used in the analysis. The $pK^0_s$ invariant mass spectrum shows a resonant structure with $M=1526\pm3(stat.)\pm 3(syst.) MeV/c^2$ and $\Gamma < 24 MeV/c^2$. The statistical significance of this peak was estimated to be of $5.6 \sigma$. The mass and width of the resonance is compatible with the recently reported $\Theta^+$- baryon with positive strangeness which was predicted as an exotic pentaquark ($uudd\bar{s}$) baryon state. The total cross section for $\Theta^+$ production in pN-interactions for $X_F\ge 0$ was estimated to be $(30\div120) \mu b$ and no essential deviation from A-dependence for inelastic events $(\sim A^{0.7})$ was found.Comment: 8 pages, 7 figures, To be submitted to Yadernaya Fizika. v3-v5 - Some references added, minor typos correcte

Properties of Neutral Charmed Mesons in Proton--Nucleus Interactions at 70 GeV

The results of treatment of data obtained in the SERP-E-184experiment "Investigation of mechanisms of the production of charmed particles in proton-nucleus interactions at 70 GeV and their decays" by irradiating the active target of the SVD-2 facility consisting of carbon, silicon, and lead plates, are presented. After separating a signal from the two-particle decay of neutral charmed mesons and estimating the cross section for charm production at a threshold energy {\sigma}(c\v{c})=7.1 \pm 2.4(stat.) \pm 1.4(syst.) \mub/nucleon, some properties of D mesons are investigated. These include the dependence of the cross section on the target mass number (its A dependence); the behavior of the differential cross sections d{\sigma}/dpt2 and d{\sigma}/dxF; and the dependence of the parameter {\alpha} on the kinematical variables xF, pt2, and plab. The experimental results in question are compared with predictions obtained on the basis of the FRITIOF7.02 code.Comment: 9 pages, 9 figures,3 table