Searching for Majorana Neutrinos at a Same-Sign Muon Collider

Majorana properties of neutrinos have long been a focus in the pursuit of possible new physics beyond the standard model, which has motivated lots of dedicated theoretical and experimental studies. A future same-sign muon collider is an ideal platform to search for Majorana neutrinos through the Lepton Number Violation process. Specifically, this t-channel kind of process is less kinematically suppressed and has a good advantage in probing Majorana neutrinos at high mass regions up to 10 TeV. In this paper, we perform a detailed fast Monte Carlo simulation study through examining three different final states: 1) pure-leptonic state with electrons or muons, 2) semi-leptonic state, and 3) pure-hadronic state in the resolved or merged categories. Furthermore, we perform a full simulation study on the pure-leptonic final state to validate our fast simulation results.Comment: 15 pages, 8 figure

The physics case for a neutrino lepton collider in light of the CDF W mass measurement

We propose a neutrino lepton collider where the neutrino beam is generated from TeV scale muon decays. Such a device would allow for a precise measurement of the W mass based on single W production: nu l to W. Although it is challenging to achieve high instantaneous luminosity with such a collider, we find that a total luminosity of 0.1/fb can already yield competitive physics results. In addition to a W mass measurement, a rich variety of physics goals could be achieved with such a collider, including W boson precision measurements, heavy leptophilic gauge boson searches, and anomalous Znunu coupling searches. A neutrino lepton collider is both a novel idea in itself, and may also be a useful intermediate step, with less muon cooling required, towards the muon-muon collider already being pursued by the energy frontier community. A neutrino neutrino or neutrino proton collider may also be interesting future options for the high energy frontier.Comment: 4 pages, 5 plots, accepted version by IJMP

High speed self-testing quantum random number generation without detection loophole

Quantum mechanics provides means of generating genuine randomness that is impossible with deterministic classical processes. Remarkably, the unpredictability of randomness can be certified in a self-testing manner that is independent of implementation devices. Here, we present an experimental demonstration of self-testing quantum random number generation based on an detection-loophole free Bell test with entangled photons. In the randomness analysis, without the assumption of independent identical distribution, we consider the worst case scenario that the adversary launches the most powerful attacks against quantum adversary. After considering statistical fluctuations and applying an 80 Gb $\times$ 45.6 Mb Toeplitz matrix hashing, we achieve a final random bit rate of 114 bits/s, with a failure probability less than $10^{-5}$. Such self-testing random number generators mark a critical step towards realistic applications in cryptography and fundamental physics tests.Comment: 34 pages, 10 figure

SARS-CoV-2 spike-reactive naïve B cells and pre-existing memory B cells contribute to antibody responses in unexposed individuals after vaccination

IntroductionSince December 2019, the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) has presented considerable public health challenges. Multiple vaccines have been used to induce neutralizing antibodies (nAbs) and memory B-cell responses against the viral spike (S) glycoprotein, and many essential epitopes have been defined. Previous reports have identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike-reactive naïve B cells and preexisting memory B cells in unexposed individuals. However, the role of these spike-reactive B cells in vaccine-induced immunity remains unknown.MethodsTo elucidate the characteristics of preexisting SARS-CoV-2 S-reactive B cells as well as their maturation after antigen encounter, we assessed the relationship of spike-reactive B cells before and after vaccination in unexposed human individuals. We further characterized the sequence identity, targeting domain, broad-spectrum binding activity and neutralizing activity of these SARS-CoV-2 S-reactive B cells by isolating monoclonal antibodies (mAbs) from these B cells.ResultsThe frequencies of both spike-reactive naïve B cells and preexisting memory B cells before vaccination correlated with the frequencies of spike-reactive memory B cells after vaccination. Isolated mAbs from spike-reactive naïve B cells before vaccination had fewer somatic hypermutations (SHMs) than mAbs isolated from spike-reactive memory B cells before and after vaccination, but bound SARS-CoV-2 spike in vitro. Intriguingly, these germline-like mAbs possessed broad binding profiles for SARS-CoV-2 and its variants, although with low or no neutralizing capacity. According to tracking of the evolution of IGHV4-4/IGKV3-20 lineage antibodies from a single donor, the lineage underwent SHMs and developed increased binding activity after vaccination.DiscussionOur findings suggest that spike-reactive naïve B cells can be expanded and matured by vaccination and cocontribute to vaccine-elicited antibody responses with preexisting memory B cells. Selectively and precisely targeting spike-reactive B cells by rational antigen design may provide a novel strategy for next-generation SARS-CoV-2 vaccine development

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

Coupled Integration of CSAC, MIMU, and GNSS for Improved PNT Performance

Positioning, navigation, and timing (PNT) is a strategic key technology widely used in military and civilian applications. Global navigation satellite systems (GNSS) are the most important PNT techniques. However, the vulnerability of GNSS threatens PNT service quality, and integrations with other information are necessary. A chip scale atomic clock (CSAC) provides high-precision frequency and high-accuracy time information in a short time. A micro inertial measurement unit (MIMU) provides a strap-down inertial navigation system (SINS) with rich navigation information, better real-time feed, anti-jamming, and error accumulation. This study explores the coupled integration of CSAC, MIMU, and GNSS to enhance PNT performance. The architecture of coupled integration is designed and degraded when any subsystem fails. A mathematical model for a precise time aiding navigation filter is derived rigorously. The CSAC aids positioning by weighted linear optimization when the visible satellite number is four or larger. By contrast, CSAC converts the GNSS observations to range measurements by “clock coasting” when the visible satellite number is less than four, thereby constraining the error divergence of micro inertial navigation and improving the availability of GNSS signals and the positioning accuracy of the integration. Field vehicle experiments, both in open-sky area and in a harsh environment, show that the integration can improve the positioning probability and accuracy

CITY FEED: A pilot system of citizen-sourcing for city issue management

Crowdsourcing implies user collaboration and engagement, which fosters a renewal of city governance processes. In this article, we address a subset of crowdsourcing, named citizen-sourcing, where citizens interact with authorities collaboratively and actively. Many systems have experimented citizen-sourcing in city governance processes; however, their maturity levels are mixed. In order to focus on the service maturity, we introduce a city service maturity framework that contains five levels of service support and two levels of information integration. As an example, we introduce CITY FEED, which implements citizen-sourcing in city issue management process. In order to support such process, CITY FEED supports all levels of the maturity framework (publishing, transacting, interacting, collaborating, and evaluating) and integrates related information relationally and heterogeneously. In order to integrate heterogeneous information, it implements a threefold feed deduplication mechanism based on the geographic, text semantic, and image similarities of feeds. Currently, CITY FEED is in a pilot stage

Delivering Knowledge to the Mobile Enterprise Implementation Solutions for a Mobile Business Intelligence.

Almost all large companies analyze their performances through KPIs that are processed by Business Intelligence (BI) systems. Specifically, BI is a critical supporting system in service industry where even a little improvement in efficiency allows you to win the competition. It implies a continuous research of excellence in BI, exploiting all technologies supporting the whole infor-mation life cycle – collection, processing and distribution. Specifically, within information distribution, mobile devices have increased BI usability, since deci-sion makers can track performance whenever (at any time) and wherever (they do not need to sit at their desk). This paper also illustrates the implementation of a mobile BI system in a cus-tomer care company. Our system uses a service-oriented architecture to inte-grate existing BI systems and our framework allows delivering a cross-platform mobile application to end users. Finally, we summarize the benefits given by a mobile BI solution in small and medium enterprises