The Effects of Children's Time Use and Home and Neighborhood Quality on their Body Weight and Cognitive/Behavioral Development

We estimate a directional distance function to assess the impacts of multiple time-varying parent and child inputs on a cluster of jointly produced child outcomes for children aged 7 to 13 years. The directional distance function specification avoids several well-known empirical problems associated with analysis of household production data, namely, the need to aggregate inputs and outputs, assume separability among inputs and outputs, or estimate reduced form equations. Using a balanced panel of families from the National Longitudinal Survey of Youth-Child Sample for 1996 to 2000, we assess the marginal contributions of home and neighborhood environmental quality and children's time allocations, on their math and reading performance, behavior problems, and body mass index. We also measure productivity growth, technical change, efficiency change, and technical efficiency for production of child outcomes. Our results indicate significant jointness among good and bad child outcomes. Significant improvements in children's good outcomes and reductions in bad outcomes are also associated with a better home and parent perceived neighborhood environment, Head Start participation, and increased family time spent together during meals. Children's productivity growth is found to be highest at age 8 years and diminishes thereafter.Health Economics and Policy, Labor and Human Capital,

Adaptation and the Option Value of Uncertain Environmental Resources

Just as ecology has benefited from the economic theory of optimization, economics can benefit from the ecological theory of adaptation. We examine the impact of short-term, nongenetic adaptive self-protection on the values individuals attach to uncertain prospective environmental resources. We demonstrate that collective provision of reductions in supply uncertainty does not necessitate a positive option value, given that uncertainty is influenced by the individual\u27s ability to adapt through self-protection. We conclude that the total value of reducing the supply uncertainty of a natural resource is reflected in both the individual\u27s option price payments for collective provision and in his willingness-to-pay for adaptation through self-protection. By ignoring adaptive self-protection, traditional benefit-cost analysis has systematically underestimated the total value of environmental resources that are characterized by uncertain supplies

Household environmental protection and the intergenerational transmission of human capital

Abstract The estimated discount rate of parents is used to test a choice-based intergenerational model of the contribution of environment to the cognitive skills of a child of a given endowment. A lower parental discount rate is shown to imply higher cognitive skills of the young child. In the context of the model, estimates also imply that environmental conditions and human capital formation are not separable. Lesser environmental quality raises the costs of human capital formation in children and lesser human capital reduces parents' demand for environmental quality. Environmental quality dierences among families, just like genetic dierences, may persist across generations.

Rheological Microscopy: Local Mechanical Properties from Microrheology

We demonstrate how tracer microrheology methods can be extended to study submicron scale variations in the viscoelastic response of soft materials; in particular, a semidilute solution of lambda-DNA. The polymer concentration is depleted near the surfaces of the tracer particles, within a distance comparable to the polymer correlation length. The rheology of this microscopic layer alters the tracers’ motion and can be precisely quantified using one- and two-point microrheology. Interestingly, we found this mechanically distinct layer to be twice as thick as the layer of depleted concentration, likely due to solvent drainage through the locally perturbed polymer structure

Identification of PSD-95 in the Postsynaptic Density Using MiniSOG and EM Tomography

Combining tomography with electron microscopy (EM) produces images at definition sufficient to visualize individual protein molecules or molecular complexes in intact neurons. When freeze-substituted hippocampal cultures in plastic sections are imaged by EM tomography, detailed structures emerging from 3D reconstructions reveal putative glutamate receptors and membrane-associated filaments containing scaffolding proteins such as postsynaptic density (PSD)-95 family proteins based on their size, shape, and known distributions. In limited instances, structures can be identified with enhanced immuno-Nanogold labeling after light fixation and subsequent freeze-substitution. Molecular identification of structure can be corroborated in their absence after acute protein knockdown or gene knockout. However, additional labeling methods linking EM level structure to molecules in tomograms are needed. A recent development for labeling structures for TEM employs expression of endogenous proteins carrying a green fluorescent tag, miniSOG, to photoconvert diaminobenzidine (DAB) into osmiophilic polymers. This approach requires initial mild chemical fixation but many of structural features in neurons can still be discerned in EM tomograms. The photoreaction product, which appears as electron-dense, fine precipitates decorating protein structures in neurons, may diffuse to fill cytoplasm of spines, thus obscuring specific localization of proteins tagged with miniSOG. Here we develop an approach to minimize molecular diffusion of the DAB photoreaction product in neurons, which allows miniSOG tagged molecule/complexes to be identified in tomograms. The examples reveal electron-dense clusters of reaction product labeling membrane-associated vertical filaments, corresponding to the site of miniSOG fused at the C-terminal end of PSD-95-miniSOG, allowing identification of PSD-95 vertical filaments at the PSD. This approach, which results in considerable improvement in the precision of labeling PSD-95 in tomograms without complications due to the presence of antibody complexes in immunogold labeling, may be applicable for identifying other synaptic proteins in intact neurons

Valuing Potential Groundwater Protection Benefits

This paper explores the implications of endogenous risk for the economic value of preventing groundwater contamination. We consider the analytical implications of endogenous risk for five key building blocks frequently used to structure studies of groundwater valuation: The probability and the location of contamination, the exposed population, risk perceptions, and Intertemporal issues