Microstructure and Physics-Based Structural Models for Suspended Clay-Exopolymer Flocs

Costal or shoreline waters are often characterized by high concentrations of suspended cohesive sediments (or clay) affected by varied organic matters (mostly extracellular polymeric substances or exopolymers), salt, and hydrodynamic disturbance. Resulting from the flocculation-disaggregation between the colloidal clay and exopolymer, the size and structure changes of the cohesive sediments are of key importance for understanding sediment transport processes (i.e., settling, breakage, and survivability) and the geotechnical and geophysical properties of the bottom bed. Because the coastal environment is extremely complicated, with many unpredictable and uncontrollable parameters, current knowledge is still insufficient to predict or fully explain the behavior of cohesive sediments. To obtain a comprehensive and in-depth understanding of cohesive sediment properties, especially with focus on the flocculation mechanism and microstructure models of clay-exopolymers, a series of sediment samples were laboratory-prepared by using four model clays, including kaolinite, illite, Ca-montmorillonite (Ca2+-Mt), and Na-montmorillonite (Na+-Mt), and three representative exopolymers (xanthan, guar, and chitosan) with different polarities in both fresh and salt waters. In order to determine the influence of each main factor in coastal environments, the suspended cohesive sediments are separated as four systems and studied systematically, which are pure clay, clay-exopolymer, clay-salt, and clay-salt-exopolymer systems. Particle size distribution (PSD), settling velocity, and microstructure of these systems were characterized by state-of-the-art techniques and developed routines. The primary PSDs of the four pure clays were first investigated via comparing different dispersion or disaggregation methods, which were used as the baseline for studying the PSD variations of other systems. Based on the synthesis of indirect PSD as well as settling velocity data and direct electron microscopy imaging, a conceptual microstructure model consisting of four hierarchical levels (i.e., primary particles, flocculi, microflocs, and macroflocs) was proposed for the clay-exopolymer flocs. The flocculation of clay-exopolymer was simplified and explained as a two-step process, including adsorption of exopolymer onto clay surfaces by intermolecular forces and packaging of clay-exopolymer groups into flocs via charge neutralization or polymer bridging. By synthesizing all the findings, a complete model was developed for clay-exopolymer floc ranging from submicron to micron scales

Orientation-dependent bending properties of selectively-filled photonic crystal fibres

A selective-filling technique was demonstrated to improve the optical properties of photonic crystal fibres (PCFs). Such a technique can be used to fill one or more fluid samples selectively into desired air holes. The technique is based on drilling a hole or carving a groove on the surface of a PCF to expose selected air holes to atmosphere by the use of a micromachining system comprising of a femtosecond infrared laser and a microscope. The exposed section was immersed into a fluid and the air holes are then filled through the well-known capillarity action [1, 2]. Provided two or more grooves are fabricated on different locations and different orientation along the fibre surface, different fluids may be filled into different air-holes to form a hybrid fibre. As an example, we filled half of a pure-silica PCF by a fluid with n=1.480 by carving a rectangular groove on the fibre (Figure 1). Consequently, the half-filled PCF became a bandgap-guiding structure (upper half), resulted from a higher refractive index in the fluid rods than in the fibre core [3], and three bandgaps were observed within the wavelength range from 600 to 1700 nm. Whereas, the lower half (unfilled holes) of the fibre remains an air/silica index-guiding structure (Figure 1(b)). When the hybrid PCF is bent, its bandgaps gradually narrowed, resulted from the shifts of the bandgap edges. The bandgap edges had distinct bend-sensitivities when the hybrid PCF was bent toward different directions. Especially, the bandgaps are hardly affected when the half-filled PCF was bent toward the fluid-filled region. Such unique bend properties could be used to monitor simultaneously the bend directions and the curvature of the engineering structures

Selectively fluid-filled microstructured optical fibers and applications

A versatile technique based on micromachining is demonstrated to fill selectively one or several different types of fluids into desired air holes in a microstructured optical fiber (MOF). Unique optical properties and applications of the selective-filled MOF are investigated

May Circulating microRNAs be Gastric Cancer Diagnostic Biomarkers?

Gastric cancer (GC) is the third leading cause of cancer-related deaths. More than 80% of the diagnosis was made at the advanced stages of the disease, highlighting the urgent demand for novel biomarkers that can be used for early detection. Recently, a number of studies suggest that circulating microRNAs (miRNAs) could be potential biomarkers for GC diagnosis. Cancer-related circulating miRNAs, as well as tissue miRNAs, provide a hopeful prospect of detecting GC at early stages, and the prospective participation of miRNAs in biomarker development will enhance the sensitivity and specificity of diagnostic tests for GC. As miRNAs in blood are stable, their potential value as diagnostic biomarkers in GC has been explored over the past few years. However, due to the inconsistent or sometimes conflicting reports, large-scale prospective studies are needed to validate their potential applicability in GC diagnosis. This review summarizes the current development about potential miRNA biomarkers for GC diagnosis and the obstacles hindering their clinical usage

Community-based Message Opportunistic Transmission

Mobile Social Networks (MSNs) is a kind of opportunistic networks, which is composed of a large number of mobile nodes with social characteristic. Up to now, the prevalent communitybased routing algorithms mostly select the most optimal social characteristic node to forward messages. But they almost don\u27t consider the effect of community distribution on mobile nodes and the time-varying characteristic of network. These algorithms usually result in high consumption of network resources and low successful delivery ratio if they are used directly in mobile social networks. We build a time-varying community-based network model, and propose a community-aware message opportunistic transmission algorithm (CMOT) in this paper. For inter-community messages transmission, the CMOT chooses an optimal community path by comparing the community transmission probability. For intra-community in local community, messages are forwarded according to the encounter probability between nodes. The simulation results show that the CMOT improves the message successful delivery ratio and reduces network overhead obviously, compared with classical routing algorithms, such as PRoPHET, MaxProp, Spray and Wait, and CMTS

High Ozone (O3) Affects the Fitness Associated with the Microbial Composition and Abundance of Q Biotype Bemisia tabaci

Abstract Ozone (O3) affects the fitness of an insect, such as its development, reproduction and protection against fungal pathogens, but the mechanism by which it does so remains unclear. Here, we compared the fitness (i.e., the growth and development time, reproduction and protection against Beauveria bassiana (B. bassiana) of Q biotype whiteflies fumigated under hO3 (280 ± 20 ppb) and control O3 (50 ± 10 ppb) concentrations. Moreover, we determined that gene expression was related to development, reproduction and immunity to B. bassiana and examined the abundance and composition of bacteria and fungi inside of the body and on the surface of the Q biotype whitefly. We observed a significantly enhanced number of eggs that were laid by a female, shortened developmental time, prolonged adult lifespan, decreased weight of one eclosion, and reduced immunity to B. bassiana in whiteflies under hO3, but hO3 did not significantly affect the expression of genes related to development, reproduction and immunity. However, hO3 obviously changed the composition of the bacterial communities inside of the body and on the surface of the whiteflies, significantly reducing Rickettsia and enhancing Candidatus_Cardinium. Similarly, hO3 significantly enhanced Thysanophora penicillioides from the Trichocomaceae family and reduced Dothideomycetes (at the class level) inside of the body. Furthermore, positive correlations were found between the abundance of Candidatus_Cardinium and the female whitefly ratio and the fecundity of a single female, and positive correlations were found between the abundance of Rickettsia and the weight of adult whiteflies just after eclosion and immunity to B. bassiana. We conclude that hO3 enhances whitefly development and reproduction but impairs immunity to B. bassiana, and our results also suggest that the changes to the microbial environments inside of the body and on the surface could be crucial factors that alter whitefly fitness under hO3. Key words: Bemisia tabaci, high ozone (hO3), fitness, microbial communities, inside of the body, on the surfac

miRNAs as potential biomarkers in early breast cancer detection following mammography

Breast cancer is the most common cancer among American women, except for skin cancers. About 12 % women in the United States will develop invasive breast cancer during their lifetime. Currently one of the most accepted model/theories is that ductal breast cancer (most common type of breast cancer) follows a linear progression: from normal breast epithelial cells to ductal hyperplasia to atypical ductal hyperplasia (ADH) to ductal carcinoma in situ (DCIS), and finally to invasive ductal carcinoma (IDC). Distinguishing pure ADH diagnosis from DCIS and/or IDC on mammography, and even combined with follow-up core needle biopsy (CNB) is still a challenge. Therefore subsequent surgical excision cannot be avoided to make a definitive diagnosis. MicroRNAs (miRNAs) are a highly abundant class of endogenous non-coding RNAs, which contribute to cancer initiation and progression, and are differentially expressed between normal and cancer tissues. They can function as either tumor suppressors or oncogenes. With accumulating evidence of the role of miRNAs in breast cancer progression, including our own studies, we sought to summarize the nature of early breast lesions and the potential use of miRNA molecules as biomarkers in early breast cancer detection. In particular, miRNA biomarkers may potentially serve as a companion tool following mammography screening and CNB. In the long-term, a better understanding of the molecular mechanisms underlying the miRNA signatures associated with breast cancer development could potentially result in the development of novel strategies for disease prevention and therapy