Abstract: The utilization of antimicrobials in animal production, causes selection of resistant bacteria. The objective of this study was to compare the utilization of alternatives in association with preventive antibiotic therapy in swine feed during the growing and finishing phases. 1,045 animals were used from 60 to 190 days of age and were subjected to six treatments with 16 repetitions as follows: 1) antibiotic free; 2) antibiotics; 3) prebiotic; 4) probiotic; 5) essential oils; and 6) organic acid. Animals were weighted, and clinical history was recorded including mortality and diarrhea. At the abattoir, pneumonia index and gastric ulcers were investigated. The cost for each treatment was discussed. No difference between treatments were observed (P>0.05) regarding feed conversion rate (2.64±0.03), overall average weight gain (107.06±0.9kg), average daily weight gain (856.49±7.7g) and carcass weight (92.4±0.7kg). The application injectable drugs in animals presenting clinical symptoms, represented US0.56/intervention,withoutdifferencebetweenthetreatments(P>0.05).Furthermore,independentlyofthetreatment,highfrequencyofpneumoniawasobserved(>0.90).Nodifferenceforthedegreeofgastriculcernorfecesconsistencywereobserved(P>0.05).Theutilizationofantibiotictherapyandalternativestoantibioticsinfeeddidnotproducebenefitstotheproductionindicesandsanitaryperformancesoftheanimals.Resumo:Autilizac\ca~odeantimicrobianosnaproduc\ca~oanimalprovocaselec\ca~odebacteˊriasresistentes.Oobjetivodoestudofoicompararautilizac\ca~odealternativasassociadasaˋantibioticoterapiapreventivanaalimentac\ca~odesuıˊnosnasfasesderecriaedeterminac\ca~o.Foramutilizados1.045animaisde60a190diasdeidade,submetidosaseistratamentoscom16repetic\co~es,comosegue:1)semantibioˊticos;2)comantibioˊticos;3)prebioˊticos;4)probioˊticos;5)oˊleosessenciais;e6)aˊcidosorga^nicos.Osanimaisforampesados,eahistoˊriaclıˊnicafoiregistrada,incluindomortalidadeediarreia.Noabatedouro,foraminvestigadosıˊndicesdepneumoniaeuˊlcerasgaˊstricas.Ocustodecadatratamentofoidiscutido.Na~ohouvediferenc\caentreostratamentos(P>0,05)emrelac\ca~oaˋtaxadeconversa~oalimentar(2,64±0,03),aoganhodepesomeˊdiogeral(107,06±0,9kg),aoganhodepesomeˊdiodiaˊrio(856,49±7,7g)eaopesodecarcac\ca(92,4±0,7kg).Aaplicac\ca~odemedicamentosinjetaˊveisemanimaiscomquadroclıˊnicorepresentouUS 0,56/intervenção, sem diferença entre os tratamentos (P>0,05). Além disso, independentemente do tratamento, foi observada alta frequência de pneumonia (>0,90). Não foi observada diferença para o grau de úlcera gástrica nem na consistência das fezes (P>0,05). A utilização de antibioticoterapia e de alternativas aos antibióticos na ração não trouxe benefícios aos desempenhos zootécnico e sanitário dos animais