THYROID DISEASES AND FEMALE REPRODUCTIVE HEALTH IN MAJOR ETHNIC GROUPS IN EASTERN SIBERIA

The paper presents the results of a retrospective analysis of reproductive and thyroid status in 1339 women (aged 27-45years) living in Eastern Siberia. 134 Mongoloid (Buryat) women and 1205 Caucasians (Russian women): 81 % women of infertile couples, 19 % of healthy women (control group) were established. High rates of hypothyroidism (18 %) in women with hyperprolactinemia and thyroid autoimmunity (7.9 and 7.2 %) in women with uterine fibroids, endometriosis and infertility, living in the Irkutsk region, was found. This study confirms the role of thyroid dysfunction in reproductive disorders. The median TSH in women with infertility Caucasians (Russian women) significantly exceeded the performance of TSH in the control group, especially in women with uterine fibroids and endometriosis. The median of FT4, the biologically active part of total thyroxin, in infertile women were in the range of reference values, were significantly lower than median of FT4 in the control group. In women with infertility, living in the Republic of Buryatia, thyroid disease was found in 2 times less compared to a resident of the Irkutsk region (14.1 % and 35 %; P (χ2) 0,05), in the structure of the thyroid diseases, in certain hormones concentrations TSH and FT4 in Russian and Buryat women with infertility, which requires further study. Discriminant analysis found the significance of changes in thyroid hormone for infertility in different ethnic groups: for infertile and fertile Russian women, living in the Republic of Buryatia, informative signs are indicators of TSH; for infertile and fertile Buryat women FT4; for women Caucasians with infertility, uterine fibroids and endometriosis, living in the Irkutsk region T3 and T4