Синтез и необычно легкая внутримолекулярная циклизация в ряду аспартильных производных гистамина

A series of natural and novel aspartyl derivatives of histamine were obtained by the classical peptide chemistry methods in a solution. During the synthesis of Nacetylaspartylhistamine easy and spontaneously cyclization of the protected Ac-AspOBzl into succinimide derivative was observed even after one day storage.Осуществлен синтез семейства природных аспартильных производных гистамина и родственных соединений. Исследована побочная реакция необычно легкой циклизации бензиловых эфиров Asp-HA

Synthesis and easy intramolecular cyclization in a number of aspartyl derivatives of histamine

A series of natural and novel aspartyl derivatives of histamine were obtained by the classical peptide chemistry methods in a solution. During the synthesis of Nacetylaspartylhistamine easy and spontaneously cyclization of the protected Ac-AspOBzl into succinimide derivative was observed even after one day storage