2,311 research outputs found
Stripes, Non-Fermi-Liquid Behavior, and High-Tc Superconductivity
The electronic structure of the high-Tc cuprates is studied in terms of
"large-U" and "small-U" orbitals. A striped structure and three types of
quasiparticles are obtained, polaron-like "stripons" carrying charge, "svivons"
carrying spin, and "quasielectrons" carrying both. The anomalous properties are
explained, and specifically the behavior of the resistivity, Hall constant, and
thermoelectric power. High-temperature superconductivity results from
transitions between pair states of quasielectrons and stripons.Comment: 4 page
The energy budget in Rayleigh-Benard convection
It is shown using three series of Rayleigh number simulations of varying
aspect ratio AR and Prandtl number Pr that the normalized dissipation at the
wall, while significantly greater than 1, approaches a constant dependent upon
AR and Pr. It is also found that the peak velocity, not the mean square
velocity, obeys the experimental scaling of Ra^{0.5}. The scaling of the mean
square velocity is closer to Ra^{0.46}, which is shown to be consistent with
experimental measurements and the numerical results for the scaling of Nu and
the temperature if there are strong correlations between the velocity and
temperature.Comment: 5 pages, 3 figures, new version 13 Mar, 200
Ordered and periodic chaos of the bounded one dimensinal multibarrier potential
Numerical analysis indicates that there exists an unexpected new ordered
chaos for the bounded one-dimensional multibarrier potential. For certain
values of the number of barriers, repeated identical forms (periods) of the
wavepackets result upon passing through the multibarrier potential.Comment: 16 pages, 9 figures, 1 Table. Some former text removed and other
introduce
Persistent global power fluctuations near a dynamic transition in electroconvection
This is a study of the global fluctuations in power dissipation and light
transmission through a liquid crystal just above the onset of
electroconvection.
The source of the fluctuations is found to be the creation and annihilation
of defects. They are spatially uncorrelated and yet temporally correlated. The
temporal correlation is seen to persist for extremely long times. There seems
to be an especially close relation between defect creation/annihilat ion in
electroconvection and thermal plumes in Rayleigh-B\'enard convection
Measurement of polarization-transfer to bound protons in carbon and its virtuality dependence
We measured the ratio of the transverse to longitudinal
components of polarization transferred from electrons to bound protons in
by the process at the
Mainz Microtron (MAMI). We observed consistent deviations from unity of this
ratio normalized to the free-proton ratio,
, for both -
and -shell knocked out protons, even though they are embedded in averaged
local densities that differ by about a factor of two. The dependence of the
double ratio on proton virtuality is similar to the one for knocked out protons
from and , suggesting a universal behavior.
It further implies no dependence on average local nuclear density
Resource Utilization Due to Breakthrough Pain in Patients With Chronic Painful Conditions
Objectives Primary: To capture healthcare resource consumption and work loss in a population of patients with chronic pain who have pain flares from one or more non-cancer conditions.
Secondary: To explore the relationship between anxiety, depression, and pain in this population
Efficacy of adenovirally expressed soluble TRAIL in human glioma organotypic slice culture and glioma xenografts
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in malignant cells, including gliomas, and is currently in anticancer clinical trials. However, the full-length and tagged forms of TRAIL, unlike the untagged ligand (soluble TRAIL (sTRAIL)), exhibits toxicity against normal cells. Here, we report the generation and testing of an adenovirus (AdsTRAIL) that expresses untagged sTRAIL in an intracranial xenograft model and a human glioma organotypic slice culture model. AdsTRAIL efficiently induced apoptosis in glioma cell lines, including those resistant to sTRAIL, but not in normal human astrocytes (NHAs). It inhibited anchorage-independent glioma growth and exerted a bystander effect in transwell assays. Intratumoral injections of AdsTRAIL in a rodent intracranial glioma model resulted in reduced tumor growth and improved survival compared with Ad-enhanced green fluorescent protein (EGFP)- or vehicle-treated controls without toxicity. Human glioma organotypic slices treated with AdsTRAIL demonstrated apoptosis induction and caspase activation
Electron correlation in C_(4N+2) carbon rings: aromatic vs. dimerized structures
The electronic structure of C_(4N+2) carbon rings exhibits competing
many-body effects of Huckel aromaticity, second-order Jahn-Teller and Peierls
instability at large sizes. This leads to possible ground state structures with
aromatic, bond angle or bond length alternated geometry. Highly accurate
quantum Monte Carlo results indicate the existence of a crossover between C_10
and C_14 from bond angle to bond length alternation. The aromatic isomer is
always a transition state. The driving mechanism is the second-order
Jahn-Teller effect which keeps the gap open at all sizes.Comment: Submitted for publication: 4 pages, 3 figures. Corrected figure
Delivery of sTRAIL variants by MSCs in combination with cytotoxic drug treatment leads to p53-independent enhanced antitumor effects
Mesenchymal stem cells (MSCs) are able to infiltrate tumor tissues and thereby effectively deliver gene therapeutic payloads. Here, we engineered murine MSCs (mMSCs) to express a secreted form of the TNF-related apoptosis-inducing ligand (TRAIL), which is a potent inducer of apoptosis in tumor cells, and tested these MSCs, termed MSC.sTRAIL, in combination with conventional chemotherapeutic drug treatment in colon cancer models. When we pretreated human colorectal cancer HCT116 cells with low doses of 5-fluorouracil (5-FU) and added MSC.sTRAIL, we found significantly increased apoptosis as compared with single-agent treatment. Moreover, HCT116 xenografts, which were cotreated with 5-FU and systemically delivered MSC.sTRAIL, went into remission. Noteworthy, this effect was protein 53 (p53) independent and was mediated by TRAIL-receptor 2 (TRAIL-R2) upregulation, demonstrating the applicability of this approach in p53-defective tumors. Consequently, when we generated MSCs that secreted TRAIL-R2-specific variants of soluble TRAIL (sTRAIL), we found that such engineered MSCs, labeled MSC.sTRAIL DR5, had enhanced antitumor activity in combination with 5-FU when compared with MSC.sTRAIL. In contrast, TRAIL-resistant pancreatic carcinoma PancTu1 cells responded better to MSC.sTRAIL DR4 when the antiapoptotic protein XIAP (X-linked inhibitor of apoptosis protein) was silenced concomitantly. Taken together, our results demonstrate that TRAIL-receptor selective variants can potentially enhance the therapeutic efficacy of MSC-delivered TRAIL as part of individualized and tumor-specific combination treatments. © 2013 Macmillan Publishers Limited All rights reserved
Perception of Breakthrough Pain in Patients with Chronic Painful Conditions
Objective: To understand how patients with chronic non-cancer pain define and describe pain flares
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