Lifestyle and late life cognitive health: Sufficient evidence to act now?

Not availabl

Intense physical activity is associated with cognitive performance in the elderly

Numerous studies have reported positive impacts of physical activity on cognitive function. However, the majority of these studies have utilised physical activity questionnaires or surveys, thus results may have been influenced by reporting biases. Through the objective measurement of routine levels of physical activity via actigraphy, we report a significant association between intensity, but not volume, of physical activity and cognitive functioning. A cohort of 217 participants (aged 60–89 years) wore an actigraphy unit for 7 consecutive days and underwent comprehensive neuropsychological assessment. The cohort was stratified into tertiles based on physical activity intensity. Compared with individuals in the lowest tertile of physical activity intensity, those in the highest tertile scored 9%, 9%, 6% and 21% higher on the digit span, digit symbol, Rey Complex Figure Test (RCFT) copy and Rey Figure Test 30-min recall test, respectively. Statistically, participants in the highest tertile of physical activity intensity performed significantly better on the following cognitive tasks: digit symbol, RCFT copy and verbal fluency test (all P<0.05). The results indicate that intensity rather than quantity of physical activity may be more important in the association between physical activity and cognitive function

Quasi-Lagrangian Large Eddy Simulations of Cross-Equatorial Flow in the East Pacific Atmospheric Boundary Layer

Using a large eddy simulation (LES), the atmospheric boundary layer (ABL) is numerically modeled along 95°W from 8°S to 4°N during boreal autumn, and compared to observations from the East Pacific Investigation of Climate Processes in the Coupled Ocean–Atmosphere System (EPIC) 2001. Since the local ABL winds are predominantly southerly in this season, a “quasi-Lagrangian” forcing is used in which the ABL air column is forced as if it were advecting northward with the mean September–October 2001 meridional wind across the equatorial cold tongue and the rapidly warming SSTs to the north. Pressure gradients and large-scale zonal advective tendencies are prescribed as a function of latitude. Where possible, observations from the EPIC 2001 experiment are used for forcing and for comparison with model results. The ABL's modeled vertical structure accords with the conceptual model of Wallace et al. and agrees well with observations. Surface stability accounts for the minimum in surface wind over the equatorial cold tongue and the maximum over the warm water to the north. Stability of the lower ABL over the cold tongue allows a jet to accelerate at about 500-m height, relatively uncoupled to the frictional surface layer. Vertical mixing over the warm water to the north distributes this momentum to the surface. Additional simulations were performed to explore the modeled ABL's sensitivity to pressure gradients, zonal advection, free-tropospheric humidity, and initial conditions. The model ABL was robust: changing the forcings resulted in little change in the modeled structure. The strongest sensitivity was of stratocumulus clouds over the cold tongue to cloud-top radiative cooling. Once formed at the southern edge of the cold tongue, modeled stratocumulus clouds demonstrate a remarkable ability to maintain themselves over the cold tongue in the absence of surface fluxes by radiative cooling at their tops. The persistence of thin stratocumulus clouds in this Lagrangian model suggests that horizontal advection of condensate might be an important process in determining cloudiness over the cold tongue

Ship Observations of the Tropical Pacific Ocean along the Coast of South America

In October 2007 the NOAA ship Ronald H. Brown sailed southward within 300 km of the coast of Ecuador and Peru, sampling surface meteorology, air–sea turbulent and radiative fluxes, cloud properties, and upper-air soundings from the equator to 20°S. Two distinct water masses characterize the coastal region: cold-pool water below 19°C in the Southern Hemisphere, and warm-pool water above 20°C to the north, with a transition between the water masses at 2.5°S. Net turbulent and radiative fluxes warm the cool water south of 2.5°S by 100 W m⁻² but do not warm the equatorial water significantly. Winds blow parallel to the shore, about 5 m s⁻¹ over the cold pool and 7 m s⁻¹ over the equator. Stratocumulus clouds are remarkably solid over the coastal cold pool, with only brief periods of partial clearing, mostly in the afternoon. Lower aerosol concentrations and thicker clouds observed farther from the coast on 22–23 October are coincident with a pocket of open cells seen to the west and southwest of the ship. Observations from this cruise and other NOAA Stratus cruises (2001 and 2003–07) are suitable for comparison with model simulations and provide context for future field experiments. These datasets are publicly available.Keywords: Pacific Ocean, South America, Ship observations, Tropic

Incidence of medication-treated depression and anxiety associated with long-term cancer, cardiovascular disease, diabetes and osteoarthritis in community-dwelling women and men

Background: Long-termcancer, cardiovascular disease, diabetes and osteoarthritismay increase the risk ofmentaldisorders, but which was more harmful and whether the associations differed between genders is unclear.Methods: We included 115,094 participants (54.3% women) aged 45–64 years from the 45 and Up Study whowere free of depression, anxiety, and Parkinson's disease at baseline (2006–2009). The incidence of depressionand anxiety was identified using claim databases during follow-up until December 2016. Cox regression modelswere used to examine the association of cancer, cardiovascular disease, diabetes, and osteoarthritis at baselinewith incident depression and anxiety.Findings: During a mean eight-year follow-up (958,785 person-year), the cumulative incidence of depression andanxiety was 12.5% and 5.9% in the healthy population. Hazard ratios ([HRs] (95% CI) versus healthy population)for incident depression associated with long-term cancer, cardiovascular disease, diabetes, and osteoarthritiswere 1.19 (95% CI: 1.13–1.25), 1.08 (1.00–1.16)), 1.18 (1.09–1.28), and 1.94 (1.80–2.10), respectively. The correspondingHRs (95% CIs) for incident anxiety were 1.11 (1.03–1.20), 1.26 (1.14–1.39), 1.10 (0.98–1.24), and 2.01(1.80–2.23), respectively. The positive association between cancer and incident depression was more evident inmen (HR (95% CI): 1.24 (1.13–1.35) than in women (1.14 (1.07–1.21). Long-term diabetes was an independentrisk factor for incident anxiety in men (1.21 (1.02–1.44) but not in women (1.09 (0.93–1.28)).Interpretation: Long-term osteoarthritis, cardiovascular disease, and cancer were independent risk factors for incidentdepression and anxiety in both genders with osteoarthritis having the highest relative risk

Nonlinear formation of holographic images of obscurations in laser beams

Computer models are used to simulate the nonlinear formation of images of obscurations in laser beams. The predictions of the model are found to be in good agreement with measurements conducted in the nonlinear regime corresponding to a typical solid-state laser operation. In this regime, peak-to-mean fluence ratios large enough to induce damage in optical components are observed. The amplitude of the images and their location along the propagation axis are accurately predicted by the simulations. This indicates that the model is a reliable design tool for specifying component staging and optical specifications to avoid optical damage by this mechanism

Dietary patterns and β-amyloid deposition in aging Australian women

Introduction: Evidence indicates that associations between diet and Alzheimer's disease may occur through biomarker pathways such as amyloid-β (Aβ); however, few studies have investigated dietary/Aβ relationships, and no study has investigated this relationship in women.Methods: Dietary patterns were extrapolated for 115 participants from the Women's Health Aging Project. Aβ deposition was measured via in vivo F-18 florbetaben positron emission tomography scanning.Results: Participants were, on average, aged 70 years (±2.63 SD), had 13 years of education (±3.57 SD), a BMI of 28 kg/m2 (±5.46 SD), and a daily energy intake of 5161 kJ (±1679.03 SD). Four dietary patterns were identified: high fat, Mediterranean, junk food, and low fat. Adherence to the junk food diet was a significant predictor of Aβ deposition (β = .10, P = .03).Discussion: This study highlights the potential of diet to influence neurodegenerative disease and as a potential modifiable lifestyle risk factor for Alzheimer's disease

Thermobaric control of gravitational potential energy generation by diapycnal mixing in the deep ocean

Sources and sinks of gravitational potential energy (GPE) play a rate-limiting role in the large scale ocean circulation. A key source is turbulent diapycnal mixing, whereby irre- versible mixing across isoneutral surfaces is enhanced by turbulent straining of these surfaces. This has motivated international observational efforts to map diapycnal mixing in the global ocean. However, in order to accurately relate the GPE supplied to the large scale circulation by diapycnal mixing to the mixing energy source, it is first necessary to determine the ratio, ξ , of the GPE generation rate to the available potential energy dissipation rate associated with turbulent mixing. Here, the link between GPE and hydro- static pressure is used to derive the GPE budget for a com- pressible ocean with a nonlinear equation of state. The role of diapycnal mixing is isolated and from this a global cli- matological distribution of ξ is calculated. It is shown that, for a given source of mixing energy, typically three times as much GPE is generated if the mixing takes place in bottom waters rather than in the pycnocline. This is due to GPE destruction by cabbelling in the pycnocline, as opposed to thermobaric enhancement of GPE generation by diapycnal mixing in the deep ocean

Adherence to a Mediterranean diet and Alzheimer's disease risk in an Australian population

The Mediterranean diet (MeDi), due to its correlation with a low morbidity and mortality for many chronic diseases, has been widely recognised as a healthy eating model. We aimed to investigate, in a cross-sectional study, the association between adherence to a MeDi and risk for Alzheimer's disease (AD) and mild cognitive impairment (MCI) in a large, elderly, Australian cohort. Subjects in the Australian Imaging, Biomarkers and Lifestyle Study of Ageing cohort (723 healthy controls (HC), 98 MCI and 149 AD participants) completed the Cancer Council of Victoria Food Frequency Questionnaire. Adherence to the MeDi (0- to 9-point scale with higher scores indicating higher adherence) was the main predictor of AD and MCI status in multinominal logistic regression models that were adjusted for cohort age, sex, country of birth, education, apolipoprotein E genotype, total caloric intake, current smoking status, body mass index, history of diabetes, hypertension, angina, heart attack and stroke. There was a significant difference in adherence to the MeDi between HC and AD subjects (P < 0.001), and in adherence between HC and MCI subjects (P < 0.05). MeDi is associated with change in Mini-Mental State Examination score over an 18-month time period (P < 0.05) in HCs. We conclude that in this Australian cohort, AD and MCI participants had a lower adherence to the MeDi than HC participants.S Gardener, Y Gu, S R Rainey-Smith, J B Keogh, P M Clifton, S L Mathieson, K Taddei, A Mondal, V K Ward, N Scarmeas, M Barnes, K A Ellis, R Head, C L Masters, D Ames, S L Macaulay, C C Rowe, C Szoeke and R N Martins for the AIBL Research Grou

Predictors of rapid cognitive decline in Alzheimer\u27s disease: Results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of ageing

Background: The AIBL study, which commenced in November 2006, is a two-center prospective study of a cohort of 1112 volunteers aged 60+. The cohort includes 211 patients meeting NINCDS-ADRDA criteria for Alzheimer\u27s disease (AD) (180 probable and 31 possible). We aimed to identify factors associated with rapid cognitive decline over 18 months in this cohort of AD patients. Methods: We defined rapid cognitive decline as a drop of 6 points or more on the Mini-Mental State Examination (MMSE) between baseline and 18-month follow-up. Analyses were also conducted with a threshold of 4, 5, 7 and 8 points, as well as with and without subjects who had died or were too severely affected to be interviewed at 18 months and after, both including and excluding subjects whose AD diagnosis was \u27possible\u27 AD. We sought correlations between rapid cognitive decline and demographic, clinical and biological variables. Results: Of the 211 AD patients recruited at baseline, we had available data for 156 (73.9%) patients at 18 months. Fifty-one patients were considered rapid cognitive decliners (32.7%). A higher Clinical Dementia Rating scale (CDR) and higher CDR \u27sum of boxes\u27 score at baseline were the major predictors of rapid cognitive decline in this population. Furthermore, using logistic regression model analysis, patients treated with a cholinesterase inhibitor (CheI) had a higher risk of being rapid cognitive decliners, as did males and those of younger age. Conclusions: Almost one third of patients satisfying established research criteria for AD experienced rapid cognitive decline. Worse baseline functional and cognitive status and treatment with a CheI were the major factors associated with rapid cognitive decline over 18 months in this population