Pengaruh Penggunaan Limbah Tapioka sebagai Sumber Belajar terhadap Motivasi dan Hasil Belajar Siswa

: This aim of this research is to know (1) the differences of students\u27 motivation and achievement after using tapioca waste as learning resource in tenth grade, MAN 2 Pati in Archaebacteria and Eubacteria materials: (2) the effects of using tapioka waste as learning resources on students\u27 motivation and achievement in tenth grade, MAN 2 Pati. This research is quasi-experimental design with randomized control group, pre-post test. The study population was all students of Class X MAN 2 Pati, while the research sample is Class X-2 as the control group and Class X-3 as the experimental group. Data collection techniques were test and non-test techniques. The analyses used the t-test to determine differences in motivation and achievement. The results show that there is difference in learning motivation after using tapioca waste as a source of learning, indicated by the result of paired samples t-test, value of sig.(2-tailed)>α. There is no difference in learning achievement after using tapioca waste as a source of learning, which is indicated by paired sample t-test, the value of sig.(2-tailed)<α. Learning motivation and achievement of students who use tapioca waste as learning resources is higher than that of students who use the conventional learning resources

The Relationship Between Multiple Intelligences with Preferred Science Teaching and Science Process Skills

This study was undertaken to identify the relationship between multiple intelligences with preferred science teaching and science process skills. The design of the study is a survey using three questionnaires reported in the literature: Multiple Intelligences Questionnaire, Preferred Science Teaching Questionnaire and Science Process Skills Questionnaire. The study selected 300 primary school students from five (5) primary schools in Penang, Malaysia. The findings showed a relationship between kinesthetic, logical-mathematical, visual-spatial and naturalistic intelligences with the preferred science teaching. In addition there was a correlation between kinesthetic and visual-spatial intelligences with science process skills, implying that multiple intelligences are related to science learning

MOESM2 of A novel Pfs38 protein complex on the surface of Plasmodium falciparum blood-stage merozoites

Additional file 2. Immunolocalization of Pfs38, Pfs41and Pfs12 in (A) schizont and (B) merozoite stage of the parasite using antibodies raised against these proteins

MOESM10 of A novel Pfs38 protein complex on the surface of Plasmodium falciparum blood-stage merozoites

Additional file 10. Evidence for the existence of Pfs38 complex by sedimentation analysis. Glycerol gradient fractionation of Plasmodium schizont extract using 5 to 45% glycerol gradient and immunoblotting of glycerol gradient fractions using anti-Pfs38, anti-Pfs41, anti-Pfs12, anti-GLURP, anti-PfMSP-165 and anti-SERA5 antibodies. Note the co-sedimentation of Pfs41, Pfs38, Pfs12, GLURP, PfMSP-165 and Sera-5 in fraction 5

MOESM12 of A novel Pfs38 protein complex on the surface of Plasmodium falciparum blood-stage merozoites

Additional file 12. Inhibition of Pfs38 glycophorin A interaction by anti-Pfs38 antibodies

Hydroxyethylamine Based Phthalimides as New Class of Plasmepsin Hits: Design, Synthesis and Antimalarial Evaluation

<div><p>A novel class of phthalimides functionalized with privileged scaffolds was designed, synthesized and evaluated as potential inhibitors of plasmepsin 2 (K_i: 0.99 ± 0.1 μM for <b>6u</b>) and plasmepsin 4 (K_i: 3.3 ± 0.3 μM for <b>6t</b>), enzymes found in the digestive vacuole of the plasmodium parasite and considered as crucial drug targets. Three compounds were identified as potential candidates for further development. The listed compounds were also assayed for their antimalarial efficacy against chloroquine (CQ) sensitive strain (3D7) of <i>Plasmodium falciparum</i>. Assay of twenty seven hydroxyethylamine derivatives revealed four (<b>5e</b>, <b>6j</b>, <b>6o</b> and <b>6s</b>) as strongly active, which were further evaluated against CQ resistant strain (7GB) of <i>P</i>. <i>falciparum</i>. Compound <b>5e</b> possessing the piperidinopiperidine moiety exhibited promising antimalarial activity with an IC₅₀ of 1.16 ± 0.04 μM. Further, compounds <b>5e</b>, <b>6j</b>, <b>6o</b> and <b>6s</b> exhibited low cytotoxic effect on MCF-7 cell line. Compound <b>6s</b> possessing <i>C</i>_<i>2</i> symmetry was identified as the least cytotoxic with significant antimalarial activity (IC₅₀: 1.30 ± 0.03 μM). The combined presence of hydroxyethylamine and cyclic amines (piperazines and piperidines) was observed as crucial for the activity. The current studies suggest that hydroxyethylamine based molecules act as potent antimalarial agent and may be helpful in drug development.</p></div

Coupling of <i>N</i>-phthaloyl-L-amino acids with 5f afforded C₂-symmetric molecules (6r-6u).

<p>Coupling of <i>N</i>-phthaloyl-L-amino acids with 5f afforded C₂-symmetric molecules (6r-6u).</p

Schematic rational design of novel hydroxyethylamine based phthalimides.

<p>Schematic rational design of novel hydroxyethylamine based phthalimides.</p

Coupling of <i>N</i>-phthaloyl-L-amino acids with functionalized hydroxyethylamines (5a-e) afforded 6a-6q.

<p>Coupling of <i>N</i>-phthaloyl-L-amino acids with functionalized hydroxyethylamines (5a-e) afforded 6a-6q.</p

Picture showing (food vacuole abnormality) and significant inhibition of ring stage parasites when treated with 5e.

<p>Picture showing (food vacuole abnormality) and significant inhibition of ring stage parasites when treated with 5e.</p