Equilibration of quantum Hall edge states by an Ohmic contact

Ohmic contacts are crucial elements of electron optics that have not received a clear theoretical description yet. We propose a model of an Ohmic contact as a piece of metal of the finite capacitance $C$ attached to a quantum Hall edge. It is shown that charged quantum Hall edge states may have weak coupling to neutral excitations in an Ohmic contact. Consequently, despite being a reservoir of neutral excitations, an Ohmic contact is not able to efficiently equilibrate edge states if its temperature is smaller than $\hbar\Omega_c$, where $\Omega_c$ is the inverse RC time of the contact. This energy scale for a floating contact may become as large as the single-electron charging energy $e^2/ C$.Comment: 5 pages, 4 figures; revised versio

Young's modulus of polyelectrolyte multilayers from microcapsule swelling

We measure Young's modulus of a free polyelectrolyte multilayer film by studying osmotically induced swelling of polyelectrolyte multilayer microcapsules filled with the polyelectrolyte solution. Different filling techniques and core templates were used for the capsule preparation. Varying the concentration of the polyelectrolyte inside the capsule, its radius and the shell thickness yielded an estimate of an upper limit for Young's modulus of the order of 100 MPa. This corresponds to an elastomer and reflects strong interactions between polyanions and polycations in the multilayer

Stages of the formation of educational employment schedule and teaching staff load distribution

The system of drawing up an academic schedule does not seem to be a single solution, but a set of individual decisions. These solutions can be based on separate software products, interacting with each other through the sharing of databases. Each individual decision is the implementation of a single step or a separate operation in the process of scheduling

Stages of the formation of educational employment schedule and teaching staff load distribution

The system of drawing up an academic schedule does not seem to be a single solution, but a set of individual decisions. These solutions can be based on separate software products, interacting with each other through the sharing of databases. Each individual decision is the implementation of a single step or a separate operation in the process of scheduling

New paradigm of processing of command line arguments

The article describes the author's method of command line arguments processing. The main features of the method, in contrast to the existing analogues, is the versatility, natively-friendly interface that allows quick start at first use and does not require deep study of documentation

New paradigm of processing of command line arguments

The article describes the author's method of command line arguments processing. The main features of the method, in contrast to the existing analogues, is the versatility, natively-friendly interface that allows quick start at first use and does not require deep study of documentation

Parametric localized modes in quadratic nonlinear photonic structures

We analyze two-color spatially localized modes formed by parametrically coupled fundamental and second-harmonic fields excited at quadratic (or chi-2) nonlinear interfaces embedded into a linear layered structure --- a quasi-one-dimensional quadratic nonlinear photonic crystal. For a periodic lattice of nonlinear interfaces, we derive an effective discrete model for the amplitudes of the fundamental and second-harmonic waves at the interfaces (the so-called discrete chi-2 equations), and find, numerically and analytically, the spatially localized solutions --- discrete gap solitons. For a single nonlinear interface in a linear superlattice, we study the properties of two-color localized modes, and describe both similarities and differences with quadratic solitons in homogeneous media.Comment: 9 pages, 8 figure

Michael addition of P-nucleophiles to azoalkenes provides simple access to phosphine oxides bearing an alkylhydrazone moiety

β-Hydrazonophosphine oxides are precursors of useful organophosphorus compounds, including phosphorylated N-heterocycles, α-aminophosphonates, and vinylphosphonates. In this work, a general transition metal-free synthesis of β-hydrazonophosphine oxides was developed. The method relies on the Michael addition of phosphine oxides R2P(O)H to reactive azoalkenes (1,2-diaza-1,3-butadienes), which are generated in situ from α-halohydrazones and Hunig’s base. The reaction stereoselectively leads to Z-isomers of β-hydrazonophosphine oxides that are stabilized by intramolecular hydrogen bonding. The conversion of the products thus obtained into potential chelating ligands was showcased

Nano-engineered microcapsules boost the treatment of persistent pain

<p>Persistent pain remains a major health issue: common treatments relying on either repeated local injections or systemic drug administration are prone to concomitant side-effects. It is thought that an alternative could be a multifunctional cargo system to deliver medicine to the target site and release it over a prolonged time window. We nano-engineered microcapsules equipped with adjustable cargo release properties and encapsulated the sodium-channel blocker QX-314 using the layer-by-layer (LbL) technology. First, we employed single-cell electrophysiology to establish <i>in vitro</i> that microcapsule application can dampen neuronal excitability in a controlled fashion. Secondly, we used two-photon excitation imaging to monitor and adjust long-lasting release of encapsulated cargo in target tissue <i>in situ</i>. Finally, we explored an established peripheral inflammation model in rodents to find that a single local injection of QX-314-containing microcapsules could provide robust pain relief lasting for over a week. This was accompanied by a recovery of the locomotive deficit and the amelioration of anxiety in animals with persistent inflammation. <i>Post hoc</i> immunohistology confirmed biodegradation of microcapsules over a period of several weeks. The overall remedial effect lasted 10–20 times longer than that of a single focal drug injection. It depended on the QX-314 encapsulation levels, involved TRPV1-channel-dependent cell permeability of QX-314, and showed no detectable side-effects. Our data suggest that nano-engineered encapsulation provides local drug delivery suitable for prolonged pain relief, which could be highly advantageous compared to existing treatments.</p