Decreased ADP-Ribosyl Cyclase Activity in Peripheral Blood Mononuclear Cells from Diabetic Patients with Nephropathy

Aims/hypothesis. ADP-ribosyl-cyclase activity (ADPRCA) of CD38 and other ectoenzymes mainly generate cyclic adenosine 5’diphosphate-(ADP-) ribose (cADPR) as a second messenger in various mammalian cells, including pancreatic beta cells and peripheral blood mononuclear cells (PBMCs). Since PBMCs contribute to the pathogenesis of diabetic nephropathy, ADPRCA of PBMCs could serve as a clinical prognostic marker for diabetic nephropathy. This study aimed to investigate the connection between ADPRCA in PBMCs and diabetic complications. Methods. PBMCs from 60 diabetic patients (10 for type 1 and 50 for type 2) and 15 nondiabetic controls were fluorometrically measured for ADPRCA based on the conversion of nicotinamide guanine dinucleotide (NGD+) into cyclic GDP-ribose. Results. ADPRCA negatively correlated with the level of HbA1c (P = .040, R2 = .073), although ADPRCA showed no significant correlation with gender, age, BMI, blood pressure, level of fasting plasma glucose and lipid levels, as well as type, duration, or medication of diabetes. Interestingly, patients with nephropathy, but not other complications, presented significantly lower ADPRCA than those without nephropathy (P = .0198) and diabetes (P = .0332). ANCOVA analysis adjusted for HbA1c showed no significant correlation between ADPRCA and nephropathy. However, logistic regression analyses revealed that determinants for nephropathy were systolic blood pressure and ADPRCA, not HbA1c. Conclusion/interpretation. Decreased ADPRCA significantly correlated with diabetic nephropathy. ADPRCA in PBMCs would be an important marker associated with diabetic nephropathy

Adjustment process of reasonable accommodation for students with disability

本研究の一部はJSPS科研費15K01683の助成を受けた。 本研究の一部は第45回中国四国大学保健管理研究集会（平成27年８月，徳島市），並びに第53回全国大学保健管理研究集会（平成27年９月，盛岡市）で発表した

Evaluation of depression when entering a university <Original Article>

近年，大学生のうつは増加傾向にあり，学校生活にも大きな影響を及ぼす。また，早期にうつ病を発症すると，その後も再発しやすく，慢性的な経過をたどる。そのために，大学メンタルヘルスの現場において，抑うつ症状の早期発見と早期治療は極めて重要である。そこで，本研究では，抑うつ症状の程度によって，BDI-IIの各項目得点に違いがあるかを検討した。その結果，自殺念慮，悲しみや喜びの消失，罪責感，活力喪失といった項目が高得点の場合には，総得点が有意に高くなることが明らかになった。また，これらの項目で高得点を示した新入生は，全体の約１％であった。今回の検討から，総得点だけでなく，自殺念慮や悲しみ，喜びの消失，罪責感，活力喪失などの項目にも注目して検討し，早期の支援につなげていく必要があると考えられた。In recent years, the number of university students with depression is increasing, and depressive symptoms have substantial impact on school life. Additionally, the early onset of depression is more likely to relapse and have a chronic course. Therefore, early detection and treatment of depressive symptoms are extremely important. We examined whether there were significant differences in item scores of BDI-II among the degrees of depressive symptoms. Results showed that the total score is significantly higher when the scores of suicidal thoughts, sadness, loss of pleasure, guilty feelings, and loss of energy are high. About one percent of the freshmen reported high scores in these items. Our study suggested importance of paying attention to the items such as suicidal thoughts, sadness, loss of pleasure, guilty feelings, and loss of energy