23 research outputs found

    Light-yield response of liquid scintillators using 2–6 MeV tagged neutrons

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    Knowledge of the neutron light-yield response is crucial to the understanding of scintillator-based neutron detectors. In this work, neutrons from 2–6MeV have been used to study the scintillation light-yield response of the liquid scintillators NE 213A, EJ 305, EJ 331 and EJ 321P using event-by-event waveform digitization. Energy calibration was performed using a GEANT4 model to locate the edge positions of the Compton distributions produced by gamma-ray sources. The simulated light yield for neutrons from a PuBe source was compared to measured recoil proton distributions, where neutron energy was selected by time-of-flight. This resulted in an energy-dependent Birks parameterization to characterize the non-linear response to the lower energy neutrons. The NE 213A and EJ 305 results agree very well with existing data and are reproduced nicely by the simulation. New results for EJ 331 and EJ 321P, where the simulation also reproduces the data well, are presented

    Quenched phosphorescence as alternative detection mode in the chiral separation of methotrexate by electrokinetic chromatography

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    Quenched phosphorescence was used, for the first time, as detection mode in the chiral separation of methotrexate (MTX) enantiomers by electrokinetic chromatography. The detection is based on dynamic quenching of the strong emission of the phosphorophore 1-bromo-4-naphthalene sulfonic acid (BrNS) by MTX under deoxygenated conditions. The use of a background electrolyte with 3 mg/mL 2-hydroxypropyl-β-cyclodextrin and 20% MeOH in 25 mM phosphate buffer (pH 7.0) and an applied voltage of 30 kV allowed the separation of l-MTX and its enantiomeric impurity d-MTX with sufficient resolution. In the presence of 1 mM BrNS, a detection limit of 3.2 × 10−7 M was achieved, about an order of magnitude better than published techniques based on UV absorption. The potential of the method was demonstrated with a degradation study and an enantiomeric purity assessment of l-MTX. Furthermore, l-MTX was determined in a cell culture extract as a proof-of-principle experiment to show the applicability of the method to biological samples

    Communication and visiting policies in Italian intensive care units during the first COVID-19 pandemic wave and lockdown: a nationwide survey

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    Background: During the first coronavirus disease 2019 (COVID-19) pandemic wave, an unprecedented number of patients with respiratory failure due to a new, highly contagious virus needed hospitalization and intensive care unit (ICU) admission. The aim of the present study was to describe the communication and visiting policies of Italian intensive care units (ICUs) during the first COVID-19 pandemic wave and national lockdown and compare these data with prepandemic conditions. Methods: A national web-based survey was conducted among 290 Italian hospitals. Each ICU (active between February 24 and May 31, 2020) was encouraged to complete an individual questionnaire inquiring the hospital/ICU structure/organization, communication/visiting habits and the role of clinical psychology prior to, and during the first COVID-19 pandemic wave. Results: Two hundred and nine ICUs from 154 hospitals (53% of the contacted hospitals) completed the survey (202 adult and 7 pediatric ICUs). Among adult ICUs, 60% were dedicated to COVID-19 patients, 21% were dedicated to patients without COVID-19 and 19% were dedicated to both categories (Mixed). A total of 11,102 adult patients were admitted to the participating ICUs during the study period and only approximately 6% of patients received at least one visit. Communication with family members was guaranteed daily through an increased use of electronic devices and was preferentially addressed to the same family member. Compared to the prepandemic period, clinical psychologists supported physicians more often regarding communication with family members. Fewer patients received at least one visit from family members in COVID and mixed-ICUs than in non-COVID ICUs, l (0 [0–6]%, 0 [0–4]% and 11 [2–25]%, respectively, p < 0.001). Habits of pediatric ICUs were less affected by the pandemic. Conclusions: Visiting policies of Italian ICUs dedicated to adult patients were markedly altered during the first COVID-19 wave. Remote communication was widely adopted as a surrogate for family meetings. New strategies to favor a family-centered approach during the current and future pandemics are warranted

    GEANT4-based calibration of an organic liquid scintillator

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    A light-yield calibration of an NE 213A organic liquid scintillator detector has been performed using both monoenergetic and polyenergetic gamma-ray sources. Scintillation light was detected in a photomultiplier tube, and the corresponding pulses were subjected to waveform digitization on an event-by-event basis. The resulting Compton edges have been analyzed using a GEANT4 simulation of the detector which models both the interactions of the ionizing radiation as well as the transport of scintillation photons. The simulation is calibrated and also compared to well-established prescriptions used to determine the Compton edges, resulting ultimately in light-yield calibration functions. In the process, the simulation-based method produced information on the gain and intrinsic pulse-height resolution of the detector. It also facilitated a previously inaccessible understanding of the systematic uncertainties associated with the calibration of the scintillation-light yield. The simulation-based method was also compared to well-established numerical prescriptions for locating the Compton edges. Ultimately, the simulation predicted as much as 17% lower light-yield calibrations than the prescriptions. These calibrations indicate that approximately 35% of the scintillation light associated with a given gamma-ray reaches the photocathode. It is remarkable how well two 50 year old prescriptions for calibrating scintillation-light yield in organic scintillators have stood the test of time

    GEANT4-based calibration of an organic liquid scintillator

    No full text
    A light-yield calibration of an NE 213A organic liquid scintillator detector has been performed using both monoenergetic and polyenergetic gamma-ray sources. Scintillation light was detected in a photomultiplier tube, and the corresponding pulses were subjected to waveform digitization on an event-by-event basis. The resulting Compton edges have been analyzed using a GEANT4 simulation of the detector which models both the interactions of the ionizing radiation as well as the transport of scintillation photons. The simulation is calibrated and also compared to well-established prescriptions used to determine the Compton edges, resulting ultimately in light-yield calibration functions. In the process, the simulation-based method produced information on the gain and intrinsic pulse-height resolution of the detector. It also facilitated a previously inaccessible understanding of the systematic uncertainties associated with the calibration of the scintillation-light yield. The simulation-based method was also compared to well-established numerical prescriptions for locating the Compton edges. Ultimately, the simulation predicted as much as 17% lower light-yield calibrations than the prescriptions. These calibrations indicate that approximately 35% of the scintillation light associated with a given gamma-ray reaches the photocathode. It is remarkable how well two 50 year old prescriptions for calibrating scintillation-light yield in organic scintillators have stood the test of time

    Technique for the measurement of intrinsic pulse-shape discrimination for organic scintillators using tagged neutrons

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    Fast-neutron/gamma-ray pulse-shape discrimination has been performed for the organic liquid scintillators NE 213A and EJ 305 using a time-of-flight based neutron-tagging technique and waveform digitization on an event-by-event basis. Gamma-ray sources and a Geant4-based simulation were used to calibrate the scintillation-light yield. The difference in pulse shape for the neutron and gamma-ray events was analyzed by integrating selected portions of the digitized waveform to produce a figure-of-merit for neutron/gamma-ray separation. This figure-of-merit has been mapped as a function of detector threshold and also of neutron energy determined from time-of-flight. It shows clearly that the well-established pulse-shape discrimination capabilities of NE 213A are superior to those of EJ 305. The extra information provided by the neutron-tagging technique has resulted in a far more detailed assessment of the pulse-shape-discrimination capabilities of these organic scintillators

    GEANT4-based calibration of an organic liquid scintillator

    No full text
    A light-yield calibration of an NE 213A organic liquid scintillator detector has been performed using bothmonoenergetic and polyenergetic gamma-ray sources. Scintillation light was detected in a photomultipliertube, and the corresponding pulses were subjected to waveform digitization on an event-by-event basis. Theresulting Compton edges have been analyzed using a GEANT4 simulation of the detector which models boththe interactions of the ionizing radiation as well as the transport of scintillation photons. The simulation is calibrated and also compared to well-established prescriptions used to determine the Compton edges,resulting ultimately in light-yield calibration functions. In the process, the simulation-based method produced information on the gain and intrinsic pulse-height resolution of the detector. It also facilitated a previously inaccessible understanding of the systematic uncertainties associated with the calibration of the scintillation-light yield. The simulation-based method was also compared to well-established numerical prescriptions for locating the Compton edges. Ultimately, the simulation predicted as much as 17% lower light-yield calibrations than the prescriptions. These calibrations indicate that approximately 35% of the scintillation light associated with a given gamma-ray reaches the photocathode. It is remarkable how well two 50 year old prescriptions for calibrating scintillation-light yield in organic scintillators have stood the test of time
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