El teorema fundamental del cálculo: Escenarios para su comprensión

Este trabajo propone tres escenarios construidos en un software dinámicoque buscan relacionar el cálculo diferencial y el integral a través de laconstrucción comprensiva del teorema fundamental del cálculo. Dichosescenarios fueron construidos tomando como base las cuatro fases quesustentan el uso de herramientas tecnológicas en la resolución de un problemapropuestas por Santos y Moreno (2013). Se resalta el acercamientovisual y empírico a través de la construcción de la derivada como la pendientede la recta tangente a una curva, la construcción de la integral definidacomo el área bajo la curva en un intervalo cerrado y cómo éstas serelacionan en el teorema fundamental del cálculo

Intra-abdominal pressure and mechanical artificial ventilation. Arnaldo Milián Castro Hospital. 2014-2015

Introduction: The abdominal cavity and the thoracic cage are separated by the diaphragm; therefore, the variations in the pressures within one of them have an effect on the pressures of the other. At present, intra-abdominal hypertension is a frequent entity in the critically ill patient, which constitutes an important risk factor for complications and mortality since it influences on different organs and systems.Objective: To relate intra-abdominal pressure with mechanical artificial ventilation pressures and parameters of respiratory, cardiovascular and renal function.Material and Methods: A descriptive prospective study of intra-abdominal pressure was conducted in patients undergoing mechanical ventilation with clinical and surgical diseases in the Intensive Care Units of the Arnaldo Milán Castro Hospital, during the period between January 2014 until December 2015. Results:  Clinical patients with high values of airway pressures showed higher values of intra-abdominal pressure, and those post-surgical patients who presented with high levels of pressure inside the abdomen indicated the highest values of peak and average pressure recorded in the mechanical ventilator.  Conclusions: Mean arterial pressure, diuretic rate and peripheral oxygen saturation decreased, whereas the central venous pressure, the partial pressure of carbon dioxide in blood, and creatinine increased due to raises in pressure within the abdomen.Keywords: Artificial respiration, transcutaneous blood gas monitoring, arterial pressure, diuresis,             abdomen.</p

Migración hacia la plataforma de productividad Microsoft 365 en empresa del sector petrolero

El presente proyecto consiste en la migración de servicios Microsoft actuales en una empresa del sector petrolero hacia la plataforma de productividad denominada Microsoft 365 para brindar mejores herramientas a la compañía, centralizar el gobierno de políticas de TI y brindar servicios eficientes que permitan colaboración, integración y seguridad con administración centralizada. Por tanto, deberá trabajarse tres frentes importantes: el primero consta en migrar la infraestructura onpremise relacionada (infraestructura que existente dentro de la empresa) hacia la nube de Microsoft de servicios como correo electrónico, comunicaciones unificadas y de gestión documental, el segundo unificar los sistemas operativos y demás software de los equipos de cómputo cliente de modo que puedan ser gestionados y administrados de manera centralizada y por último, un componente de capacitación acerca las herramientas que ofrece Microsoft Office 365 de modo que su adopción permita mejorar la productividad de la compañía. Es por ello que Microsoft 365 será el apalancador de transformación digital hacia una nueva forma de trabajar, más colaborativa y productiva para que todos los funcionarios y colaboradores de la empresa del sector petrolero realicen de una manera más fácil y eficiente su trabajo diario, abriendo también nuevos espacios de innovación.This project consists of the migration of current Microsoft services in a company in the oil sector to the productivity platform called Microsoft 365 to provide better tools to the company, centralize the governance of IT policies and provide efficient services that calculate collaboration, and security with centralized administration. Therefore, three important fronts must be worked on: the first consists of migrating the related onpremise infrastructure (infrastructure that exists within the company) to the Microsoft cloud of services such as email, unified communications and document management, the second unifying the systems operations and other software of the client computer equipment so that they can be managed and administered centrally and finally, a training component in the tools offered by Office 365 so that its adoption allows to improve the productivity of the company. That is why Microsoft 365 will be the lever of digital transformation towards a new way of working, more collaborative and productive so that all the employees and collaborators of the oil sector company can carry out their daily work in an easier and more efficient way, also opening new spaces for innovation

Next Generation Mashups: Cómo Crear mis Propios Servicios en un Mundo Convergente.

Mashups have become a mainstream of the Web. Recently, several mashup platforms have introduced the usercentric paradigm, thus allowing end-users to create, share and enjoy their own services. However, these platforms still lack the advanced features that the mobile Web is able to support, other than just browsing on the mobile telephone. Advanced location features and the possibility of communicating from anywhere at anytime will leverage new business models thus providing end-users with amazing new services. This paper introduces a platform that merges user-centricity and mobile Web services with a mashup environment, and describes its main features

Regulation of the transcriptional program by DNA methylation during human αβ T-cell development

© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research. Thymocyte differentiation is a complex process involving well-defined sequential developmental stages that ultimately result in the generation of mature T-cells. In this study, we analyzed DNA methylation and gene expression profiles at successive human thymus developmental stages. Gain and loss of methylation occurred during thymocyte differentiation, but DNA demethylation was much more frequent than de novo methylation and more strongly correlated with gene expression. These changes took place in CpG-poor regions and were closely associated with T-cell differentiation and TCR function. Up to 88 genes that encode transcriptional regulators, some of whose functions in T-cell development are as yet unknown, were differentially methylated during differentiation. Interestingly, no reversion of accumulated DNA methylation changes was observed as differentiation progressed, except in a very small subset of key genes (RAG1, RAG2, CD8A, PTCRA, etc.), indicating that methylation changes are mostly unique and irreversible events. Our study explores the contribution of DNA methylation to T-cell lymphopoiesis and provides a fine-scale map of differentially methylated regions associated with gene expression changes. These can lay the molecular foundations for a better interpretation of the regulatory networks driving human thymopoiesis.Plan Nacional de [I+D+I 2008–2011]; Instituto de Salud Carlos III [grant number PI12/02587]; Red Española de Investigación Renal (REDinREN) [grant number RD12/0021/0018 and RD12/0021/0021]; Spanish Ministry of Science and Innovation [grant number SAF2010- 15106 and PLE2009-0110]; European Union [Fondos FEDER]Peer Reviewe

Modelo de encriptación simétrica basada en atractores caóticos

Context: the increase in the processing capacity of machines and developments in combinatorial search algorithms reduces the time required to decipher the information fraudulently. Bear in mind this, there is a need to generate new ways of encoding information for secure transmission.Method: in this paper a symmetrical and extensible model for digital communications encryption is presented, taking advantage of the chaos generated by nonlinear dynamic systems.Results: the developed model proved to encrypt messages in time synchronization, encryption and decryption less than 1 ms with an entropy higher than 6 using the Rössler attractor for its implementation.Conclusions: the algorithm is presented as an alternative to traditional algorithms demonstrating greater efficiency in the management of computing resources and raises the groundwork for continuing their study on the interested academic community due to the variety of dynamical systems nonlinear.Contexto: El aumento en la capacidad de procesamiento de las máquinas y los desarrollos en los algoritmos de búsqueda combinatoria disminuyen el tiempo necesario para descifrar fraudulentamente la información; por esta razón se plantea la necesidad de generar nuevas formas de codificar la  información para su transmisión segura.Método: En este artículo se presenta un modelo de encriptación simétrico extensible para comunicaciones digitales, aprovechando el caos generado por sistemas dinámicos no lineales.  Resultados: El modelo desarrollado demostró estar en la capacidad de encriptar mensajes en tiempos de sincronización, encriptación y desencriptación inferiores a 1 ms con una entropía superior a 6 usando el atractor de Rossler para su implementación.Conclusiones: El algoritmo se presenta como una alternativa a los algoritmos tradicionales de combinatoria demostrando una mayor eficiencia en la gestión de recursos computacionales y plantea las bases para su continuar con su estudio en la comunidad académica interesada, debido a la variedad de los sistemas dinámicos no lineales.

IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment

Homeostatic programs balance immune protection and self-tolerance. Such mechanisms likely impact autoimmunity and tumor formation, respectively. How homeostasis is maintained and impacts tumor surveillance is unknown. Here, we find that different immune mononuclear phagocytes share a conserved steady-state program during differentiation and entry into healthy tissue. IFNγ is necessary and sufficient to induce this program, revealing a key instructive role. Remarkably, homeostatic and IFNγ-dependent programs enrich across primary human tumors, including melanoma, and stratify survival. Single-cell RNA sequencing (RNA-seq) reveals enrichment of homeostatic modules in monocytes and DCs from human metastatic melanoma. Suppressor-of-cytokine-2 (SOCS2) protein, a conserved program transcript, is expressed by mononuclear phagocytes infiltrating primary melanoma and is induced by IFNγ. SOCS2 limits adaptive anti-tumoral immunity and DC-based priming of T cells in vivo, indicating a critical regulatory role. These findings link immune homeostasis to key determinants of anti-tumoral immunity and escape, revealing co-opting of tissue-specific immune development in the tumor microenvironment. Keywords: dendritic cells; homeostasis; differentiation; IFNγ; tumor microenvironment; melanoma tolerance; immunotherapy; suppressor-of-cytokine-signaling 2 (SOCS2); tissue mononuclear phagocyte

Genetically predicted telomere length and Alzheimer’s disease endophenotypes: a Mendelian randomization study

Telomere length (TL) is associated with biological aging, consequently influencing the risk of age-related diseases such as Alzheimer's disease (AD). We aimed to evaluate the potential causal role of TL in AD endophenotypes (i.e., cognitive performance, N = 2233; brain age and AD-related signatures, N = 1134; and cerebrospinal fluid biomarkers (CSF) of AD and neurodegeneration, N = 304) through a Mendelian randomization (MR) analysis. Our analysis was conducted in the context of the ALFA (ALzheimer and FAmilies) study, a population of cognitively healthy individuals at risk of AD. A total of 20 single nucleotide polymorphisms associated with TL were used to determine the effect of TL on AD endophenotypes. Analyses were adjusted by age, sex, and years of education. Stratified analyses by APOE-epsilon 4 status and polygenic risk score of AD were conducted. MR analysis revealed significant associations between genetically predicted longer TL and lower levels of CSF A beta and higher levels of CSF NfL only in APOE-epsilon 4 non-carriers. Moreover, inheriting longer TL was associated with greater cortical thickness in age and AD-related brain signatures and lower levels of CSF p-tau among individuals at a high genetic predisposition to AD. Further observational analyses are warranted to better understand these associations

Impact of Biological Agents on Postsurgical Complications in Inflammatory Bowel Disease : A Multicentre Study of Geteccu

Background: The impact of biologics on the risk of postoperative complications (PC) in inflammatory bowel disease (IBD) is still an ongoing debate. This lack of evidence is more relevant for ustekinumab and vedolizumab. Aims: To evaluate the impact of biologics on the risk of PC. Methods: A retrospective study was performed in 37 centres. Patients treated with biologics within 12 weeks before surgery were considered "exposed". The impact of the exposure on the risk of 30-day PC and the risk of infections was assessed by logistic regression and propensity score-matched analysis. Results: A total of 1535 surgeries were performed on 1370 patients. Of them, 711 surgeries were conducted in the exposed cohort (584 anti-TNF, 58 vedolizumab and 69 ustekinumab). In the multivariate analysis, male gender (OR: 1.5; 95% CI: 1.2-2.0), urgent surgery (OR: 1.6; 95% CI: 1.2-2.2), laparotomy approach (OR: 1.5; 95% CI: 1.1-1.9) and severe anaemia (OR: 1.8; 95% CI: 1.3-2.6) had higher risk of PC, while academic hospitals had significantly lower risk. Exposure to biologics (either anti-TNF, vedolizumab or ustekinumab) did not increase the risk of PC (OR: 1.2; 95% CI: 0.97-1.58), although it could be a risk factor for postoperative infections (OR 1.5; 95% CI: 1.03-2.27). Conclusions: Preoperative administration of biologics does not seem to be a risk factor for overall PC, although it may be so for postoperative infections

POR UNA CULTURA DE PAZ: UNA MIRADA DESDE LAS CIENCIAS DE LA CONDUCTA

En
 virtud
 de
 lo
 anterior,
 los
 estudiosos
 de
 las
 ciencias
 de
 la
 conducta
 
de
 la
 Universidad
Autónoma 
del
 Estado 
de 
México,

ante 
la
persistencia
 y 
proliferación
 de
 estos 
hechos
 en
 diversas
 partes
 del
Mundo
 y
 de
 nuestro 
país 
en 
particular, se
 convocó
 a
 los
 estudiosos
 interesados
 y
 a
 la
 sociedad
 en
 general
 a
 presentar
 trabajos
 para
 analizar,
 debatir
 y
 proponer
 estrategias
 de
 acción
 y
 dirección,
 que
 fortalezcan
 una
 convivencia y bienestar con sentido humanista para una cultura de paz. El
 presente
 texto
 es
 producto
 de 
esta convocatoria 
que
 recoge 
los
trabajos 
de 

los
 interesados 
en 
la
 temática,

 de
 diferentes 
países
(España,
Argentina,
Cuba,
Brasil,
Costa
 Rica
 y
 México)
 retomando
 con
 ello
 sus
 experiencias
 relativas
 al
 estudio,
 análisis,
 comprensión
 e
 instrumentación
 de
 la
 cultura
 de
 paz
 en
 los
 distintos
 ámbitos
 institucionales
 en
 los
 que
 participan:
 educativo,
 salud,
 penitenciario,
 social,
laboral,
familia,
alimentario,
psicológico,
por 
mencionar 
algunos.
 El
 presente
 libro,
 propicia
 un
 espacio
 de
 reflexión,
 diálogo
 y
 posicionamiento
 de
 las 
ciencias 
de 
la 
conducta
 para 
la 
apropiación,
análisis,
debate
 y 
propuestas 
que
 fortalezcan 
una
 cultura
 de 
paz
 a
través
 de 
la
 convivencia 
y
 el 
bienestar
 social 
con
 sentido 
humanista.
El
 sistema 
económico
 neoliberal
 y 
el 
proceso
 de 
globalización 
han
 contribuido
al
 logro
 de
 avances
 significativos
 en
 la
 ciencia
 y
 la
 tecnología,
 pero
 también
 han
 propiciado
 la
 polarización
 de
 las
 sociedades
 lo
 que
 ha
 impactado
 de
 manera
 negativa
 a
 la
 sociedad
 en
 su
 conjunto,
 pero
 en
 mayor
 medida
 a
 los grupos
 vulnerables. Dicha
 polarización
 ha
 traído
 consigo
 un
 desarrollo
 desigual
 del
 mundo
 que
 se
 expresa
 de
 diferentes
 maneras
 tanto
 en
 países
 desarrollados
 como
 en
 los
 llamados
 del
 tercer
 mundo,
 en
 donde
 no
 están
 satisfechas
 las
 necesidades
 humanas 
elementales
 de
 todos 
los
sectores 
de 
la 
población,
siempre 
falta 
algo. 
Si 
a
 esto 
le
 sumamos 
los
conflictos
 internacionales por
 diferentes
 motivos
 que
 enfrentan
 algunas
 naciones,
 una
 insuficiente
 cobertura
 educativa
 y
 de
 salud,

 desempleo
 y
 pobreza 
extrema,
 entre 
otras
 cosas; 
estamos
 frente
 a
retos 
de
 gran
 envergadura
 para
 los
 gobiernos,
 para
 los
 estudiosos
 y
 para
 la
 sociedad
 civil
 en
 general. Uno 
de 
los
 intentos
 para
 frenar 
y prevenir 
la
 agudización
 de 
estas 
problemáticas
 es
 la
 cultura 
de 
paz,
cuyo
 estudio
y propuestas 
han 
ido 
avanzando 
en 
diferentes
 sentidos 
y 
de 
manera 
favorable,
el 
tema 
está 
presente 
en 
diferentes 
Organismos
 Internacionales
 como
 la
 ONU,
 la
 UNESCO,
 la
 OCDE,
 El
 Banco
 Mundial,
 entre
 otros.
 Pero
 falta 
mucho 
por 
hacer.Universidad Autónoma del Estado de Méxic