Non-damping oscillations at flaring loops

Context. QPPs are usually detected as spatial displacements of coronal loops in imaging observations or as periodic shifts of line properties in spectroscopic observations. They are often applied for remote diagnostics of magnetic fields and plasma properties on the Sun. Aims. We combine imaging and spectroscopic measurements of available space missions, and investigate the properties of non-damping oscillations at flaring loops. Methods. We used the IRIS to measure the spectrum over a narrow slit. The double-component Gaussian fitting method was used to extract the line profile of Fe XXI 1354.08 A at "O I" window. The quasi-periodicity of loop oscillations were identified in the Fourier and wavelet spectra. Results. A periodicity at about 40 s is detected in the line properties of Fe XXI, HXR emissions in GOES 1-8 A derivative, and Fermi 26-50 keV. The Doppler velocity and line width oscillate in phase, while a phase shift of about Pi/2 is detected between the Doppler velocity and peak intensity. The amplitudes of Doppler velocity and line width oscillation are about 2.2 km/s and 1.9 km/s, respectively, while peak intensity oscillate with amplitude at about 3.6% of the background emission. Meanwhile, a quasi-period of about 155 s is identified in the Doppler velocity and peak intensity of Fe XXI, and AIA 131 A intensity. Conclusions. The oscillations at about 40 s are not damped significantly during the observation, it might be linked to the global kink modes of flaring loops. The periodicity at about 155 s is most likely a signature of recurring downflows after chromospheric evaporation along flaring loops. The magnetic field strengths of the flaring loops are estimated to be about 120-170 G using the MHD seismology diagnostics, which are consistent with the magnetic field modeling results using the flux rope insertion method.Comment: 9 pages, 9 figures, 1 table, accepted by A&

Entanglement area law for 1D gauge theories and bosonic systems

We prove an entanglement area law for a class of 1D quantum systems involving infinite-dimensional local Hilbert spaces. This class of quantum systems include bosonic models such as the Hubbard-Holstein model, and both U(1) and SU(2) lattice gauge theories in one spatial dimension. Our proof relies on new results concerning the robustness of the ground state and spectral gap to the truncation of Hilbert space, applied within the approximate ground state projector (AGSP) framework from previous work. In establishing this area law, we develop a system-size independent bound on the expectation value of local observables for Hamiltonians without translation symmetry, which may be of separate interest. Our result provides theoretical justification for using tensor network methods to study the ground state properties of quantum systems with infinite local degrees of freedom

Stemness factor Sall4 is required for DNA damage response in embryonic stem cells.

Mouse embryonic stem cells (ESCs) are genetically more stable than somatic cells, thereby preventing the passage of genomic abnormalities to their derivatives including germ cells. The underlying mechanisms, however, remain largely unclear. In this paper, we show that the stemness factor Sall4 is required for activating the critical Ataxia Telangiectasia Mutated (ATM)-dependent cellular responses to DNA double-stranded breaks (DSBs) in mouse ESCs and confer their resistance to DSB-induced cytotoxicity. Sall4 is rapidly mobilized to the sites of DSBs after DNA damage. Furthermore, Sall4 interacts with Rad50 and stabilizes the Mre11-Rad50-Nbs1 complex for the efficient recruitment and activation of ATM. Sall4 also interacts with Baf60a, a member of the SWI/SNF (switch/sucrose nonfermentable) ATP-dependent chromatin-remodeling complex, which is responsible for recruiting Sall4 to the site of DNA DSB damage. Our findings provide novel mechanisms to coordinate stemness of ESCs with DNA damage response, ensuring genomic stability during the expansion of ESCs

The yeast ubiquitin ligase SCF(Met30): connecting environmental and intracellular conditions to cell division

Ubiquitination regulates a host of cellular processes and is well known for its role in progression through the cell division cycle. In budding yeast, cadmium and arsenic stress, the availability of sulfur containing amino acids, and the intracellular concentration of S-adenosylmethionine are linked to cell cycle regulation through the ubiquitin ligase SCF(Met30). Regulation is achieved by ubiquitination of the transcription factor Met4. Met4 activity is controlled by a regulatory K48-linked ubiquitin chain that is synthesized by Cdc34/SCF(Met30). A ubiquitin-interacting-motif (UIM) present in Met4 prevents degradation of ubiquitinated Met4 allowing the ubiquitin chain to function as a reversible switch of Met4 activity. Here we discuss mechanisms of Met4 and SCF(Met30 )regulation in response to intracellular and environmental conditions, and describe the integration of these signals with cell cycle control

An ultra-long and quite thin coronal loop without significant expansion

Context. Coronal loops are the basic building blocks of the solar corona, which are related to the mass supply and heating of solar plasmas in the corona. However, their fundamental magnetic structures are still not well understood. Most coronal loops do not expand significantly, whereas the diverging magnetic field would have an expansion factor of about 5-10 over one pressure scale height. Aims. In this study, we investigate a unique coronal loop with a roughly constant cross section, it is ultra long and quite thin. A coronal loop model with magnetic helicity is presented to explain the small expansion of the loop width. Methods. This coronal loop was predominantly detectable in the 171 A channel of the Atmospheric Imaging Assembly (AIA). Then, the local magnetic field line was extrapolated by a Potential-Field-Source-Surface model. Finally, the differential emission measure analysis made from six AIA bandpasses was applied to obtain the thermal properties of this loop. Results. This coronal loop has a projected length of roughly 130 Mm, a width of about 1.5 +(-) 0.5 Mm and a lifetime of around 90 minutes. It follows an open magnetic field line. The cross section expanded very little (i.e., 1.5-2.0) along the loop length during its whole lifetime. This loop has a nearly constant temperature at about 0.7 +(-) 0.2 MK, whereas its density exhibits the typical structure of a stratified atmosphere. Conclusions. We use a thin twisted flux tube theory to construct a model for this non-expanding loop, and find that indeed with sufficient twist a coronal loop can attain equilibrium. However, we can not rule out other possibilities such as footpoint heating by small-scale reconnection, elevated scale height by a steady flow along the loop etc.Comment: 8 pages, 5 figures, 1 table

Plaquette Singlet Transition, Magnetic Barocaloric Effect, and Spin Supersolidity in the Shastry-Sutherland Model

Inspired by recent experimental measurements [Guo \textit{et al.}, Phys. Rev. Lett.~\textbf{124}, 206602 (2020); Jim\'enez \textit{et al.}, Nature \textbf{592}, 370 (2021)] on frustrated quantum magnet SrCu$_2$(BO$_3$)$_2$ under combined pressure and magnetic fields, we study the related spin-$1/2$ Shastry-Sutherland (SS) model using state-of-the-art tensor network methods. By calculating thermodynamics, correlations and susceptibilities, we find, in zero magnetic field, not only a line of first-order plaquette-singlet (PS) to dimer-singlet phase transition ending with a critical point, but also signatures of the ordered PS transition with its critical endpoint terminating on this first-order line. Moreover, we uncover prominent magnetic barocaloric responses, a novel type of quantum correlation induced cooling effect, in the strongly fluctuating supercritical regime. Under finite fields, we identify a quantum phase transition from the PS phase to the spin supersolid phase that breaks simultaneously lattice translational and spin rotational symmetries. The present findings on the SS model are accessible in current experiments and would shed new light on exotic critical and supercritical phenomena in archetypal frustrated quantum magnets.Comment: Close to the published version. 7 pages, 4 figures (SM 9 pages, 12 figures

Therapeutic potential of Erxian decoction and its special chemical markers in depression: a review of clinical and preclinical studies

The increasing prevalence of depression is a major societal burden. The etiology of depression involves multiple mechanisms. Thus, the outcomes of the currently used treatment for depression are suboptimal. The anti-depression effects of traditional Chinese medicine (TCM) formulations have piqued the interest of the scientific community owing to their multi-ingredient, multi-target, and multi-link characteristics. According to the TCM theory, the functioning of the kidney is intricately linked to that of the brain. Clinical observations have indicated the therapeutic potential of the kidney-tonifying formula Erxian Decoction (EXD) in depression. This review aimed to comprehensively search various databases to summarize the anti-depression effects of EXD, explore the underlying material basis and mechanisms, and offer new suggestions and methods for the clinical treatment of depression. The clinical and preclinical studies published before 31 August 2023, were searched in PubMed, Google Scholar, China National Knowledge Infrastructure, and Wanfang Database. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Clinical studies have demonstrated that EXD exhibits therapeutic properties in patients with menopausal depression, postpartum depression, and maintenance hemodialysis-associated depression. Meanwhile, preclinical studies have reported that EXD and its special chemical markers exert anti-depression effects by modulating monoamine neurotransmitter levels, inhibiting neuroinflammation, augmenting synaptic plasticity, exerting neuroprotective effects, regulating the hypothalamic-pituitary-adrenal axis, promoting neurogenesis, and altering cerebrospinal fluid composition. Thus, the anti-depression effects of EXD are mediated through multiple ingredients, targets, and links. However, further clinical and animal studies are needed to investigate the anti-depression effects of EXD and the underlying mechanisms and offer additional evidence and recommendations for its clinical application. Moreover, strategies must be developed to improve the quality control of EXD. This review provides an overview of EXD and guidance for future research direction

Overexpression of ERBB-2 was more frequently detected in malignant than benign pheochromocytomas by multiplex ligation-dependent probe amplification and immunohistochemistry

To analyze the genetic alterations of pheochromocytomas and evaluate the difference among malignant, extra-adrenal, and benign pheochromocytomas. Forty-three tumor samples were tested for genetic changes using multiplex ligation-dependent probe amplification. Among them, 39 samples were available for protein expression analysis by immunohistochemistry (IHC). All 43 patients (24 women and 19 men; mean age 44.6±13.6 years; range 18–75 years; 9 with malignant, 7 extra-adrenal, and 27 benign) showed multiple copy number losses or gains. The average copy number change was 13.10 in malignant, 13.93 in benign, and 13.47 in paraganglioma patients. There is no significant difference among the three groups of pheochromocytomas. However, we discovered that in the malignant pheochromocytomas, 6 of the 9 patients (67%) showed erythroblastic leukemia viral oncogene homolog 2 (ERBB-2) oncogene gain, whereas only 12 of the 34 (35%) identified change in the benign and extra-adrenal pheochromocytomas. Further, IHC confirmed that ERBB-2-positive staining was more frequent and stronger in malignant pheochromocytomas than in benign and extra-adrenal pheochromocytomas. Our study illustrates the chromosomal changes of the whole genome of Chinese pheochromocytoma patients. The results suggest that there may be certain progression of genetic events that involves chromosomes 1p, 3p, 6p, 11q, 12q, 17q, and 19q in the development of pheochromocytomas, and the activation of ERBB-2 located on chromosome 17q is an important and early event in the malignancy development of these tumor types. The overexpression of ERBB-2 identified by IHC suggested that this oncogene could be associated with the malignancy of pheochromocytomas and paragangliomas

A Multiparametric Method Based on Clinical and CT-Based Radiomics to Predict the Expression of p53 and VEGF in Patients With Spinal Giant Cell Tumor of Bone

PurposeThis project aimed to assess the significance of vascular endothelial growth factor (VEGF) and p53 for predicting progression-free survival (PFS) in patients with spinal giant cell tumor of bone (GCTB) and to construct models for predicting these two biomarkers based on clinical and computer tomography (CT) radiomics to identify high-risk patients for improving treatment.Material and methodsA retrospective study was performed from April 2009 to January 2019. A total of 80 patients with spinal GCTB who underwent surgery in our institution were identified. VEGF and p53 expression and clinical and general imaging information were collected. Multivariate Cox regression models were used to verify the prognostic factors. The radiomics features were extracted from the regions of interest (ROIs) in preoperative CT, and then important features were selected by the SVM to build classification models, evaluated by 10-fold crossvalidation. The clinical variables were processed using the same method to build a conventional model for comparison.ResultsThe immunohistochemistry of 80 patients was obtained: 49 with high-VEGF and 31 with low-VEGF, 68 with wild-type p53, and 12 with mutant p53. p53 and VEGF were independent prognostic factors affecting PFS found in multivariate Cox regression analysis. For VEGF, the Spinal Instability Neoplastic Score (SINS) was greater in the high than low groups, p < 0.001. For p53, SINS (p = 0.030) and Enneking stage (p = 0.017) were higher in mutant than wild-type groups. The VEGF radiomics model built using 3 features achieved an area under the curve (AUC) of 0.88, and the p53 radiomics model built using 4 features had an AUC of 0.79. The conventional model built using SINS, and the Enneking stage had a slightly lower AUC of 0.81 for VEGF and 0.72 for p53.Conclusionp53 and VEGF are associated with prognosis in patients with spinal GCTB, and the radiomics analysis based on preoperative CT provides a feasible method for the evaluation of these two biomarkers, which may aid in choosing better management strategies