The Grizzly, October 23, 1987

Middle States to Evaluate the Ursinus Community • Gilmore Tops Successful Homecoming • Greek Life Threatened • Letters: Pledging Restrictions Destructive?; Professor Supports Religious Understanding • Hot Entertainment to Hit Ursinus • As We Begin the World • Dance Forum Dazzles Audience • Scholars Offer Variety • Old Wine in New Bottles • Speech Exam Offered • Surf\u27s Up for the Lady Bears • Ursinus Athletes and Coach Win at Homecoming • This Run\u27s for you Vince • Athlete of the Week: Football\u27s Glenn Worgan • Grizzlies to Hang Tough • Choral Groups to Entertain Ursinus • WVOU is Back! • Ritter Center: A Beehive of Busyness the Busie Body to Premiere Oct. 29 • Owners Strike Backhttps://digitalcommons.ursinus.edu/grizzlynews/1197/thumbnail.jp

OCT4 induces embryonic pluripotency via STAT3 signaling and metabolic mechanisms.

OCT4 is a fundamental component of the molecular circuitry governing pluripotency in vivo and in vitro. To determine how OCT4 establishes and protects the pluripotent lineage in the embryo, we used comparative single-cell transcriptomics and quantitative immunofluorescence on control and OCT4 null blastocyst inner cell masses at two developmental stages. Surprisingly, activation of most pluripotency-associated transcription factors in the early mouse embryo occurs independently of OCT4, with the exception of the JAK/STAT signaling machinery. Concurrently, OCT4 null inner cell masses ectopically activate a subset of trophectoderm-associated genes. Inspection of metabolic pathways implicates the regulation of rate-limiting glycolytic enzymes by OCT4, consistent with a role in sustaining glycolysis. Furthermore, up-regulation of the lysosomal pathway was specifically detected in OCT4 null embryos. This finding implicates a requirement for OCT4 in the production of normal trophectoderm. Collectively, our findings uncover regulation of cellular metabolism and biophysical properties as mechanisms by which OCT4 instructs pluripotency.This work was supported by the University of Cambridge, BBSRC project grant RG74277, BB/R018588/1 and MR/R017735/1 to HS and LB respectively, MRC PhD studentship for AK and a core support grant from the Wellcome Trust and MRC to the Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute

The Grizzly, October 9, 1987

Sororities Sing for Sisterhood: Welcome Pledges • The Tradition Continues • Letter: Student Defends Administration • U.C.: Phone Home • It Will be Dry and Cloudy • Student Adds up to Scholarship • Evening School Promotes Image • East Asian Studies Continue • Injuries Plague Hockey • Bears Ride the Tide • Athlete of the Week: Volleyball\u27s Donna Mignemi • Baseball Numbers Add Up • Soccer Successful vs. Lebanon • O\u27Donahue Cruisin\u27 to the Top • Malone Fills Void • ProTheatre • Jewish Information Offeredhttps://digitalcommons.ursinus.edu/grizzlynews/1195/thumbnail.jp

The Grizzly, November 3, 1989

Wismer Woes • Curriculum Changes Affect all Students at U.C. • Letters: A Voice for Love ; Coaching Cowardess • Alcohol Awareness • Club Sails Smoothly • For Nature\u27s Nurture • Bears Struggle with Division I • Honors Galore • X-C Teams Look to MAC\u27s • Hoopla!https://digitalcommons.ursinus.edu/grizzlynews/1245/thumbnail.jp

The Grizzly, February 26, 1991

The Gulf War: How Will It Affect the Economy? • Airband Competition Enters Its Eighth Year • Sears-Roebuck Award, A Boon for Faculty • How Will the War End? • My First College Field Trip • McCabe Wins Contest • John Lionarons Performs • Dan Pasquale • Steel Magnolias • L.A Story • Peter Benchley\u27s Rummies • Flatliners • Former Monsters of Rock • City Art: Pop Art Prints • Angelos Resigns as Head Basketball Coach at Ursinus • Swimmers Place High at MAC Championships • Lady Bears Look to ECAC Play-off • Track Women Improve at Invitational • Wrestlers Place Fourth at MAC\u27s • Letter: Schafer Bashes Harley\u27s Haven • I Cannot Accept it • Most Selective - Bio/Pre-Med at Ursinus • Feeling lazy? -Could be CFS • Science Careershttps://digitalcommons.ursinus.edu/grizzlynews/1272/thumbnail.jp

The Grizzly, February 24, 1989

Ursinus Finds and Dumps Its Own Dump • Depression Treatable • GPA Lowered for Frat Pledges • Letter: Mannherz Assaults Grizzly • Myrin Library Meeting Future • Photos Don\u27t Show All, More to Dump Than Meets the Eye • Ursinus Awaits ECAC Bid • Matters Set School Record • McMullin Keys U.C. Track • U.C.: Up, Then Down • Ursinus Women: The Stuff of Champions • Cinders Smoking • Meisters: Ohio or Bust! • Richter Doesn\u27t Trash Klee • Wismer Deceiving Diners • DeCatur Nips Nippon • Yanks and Frogs Alike • Airband Tonight • Graduation 1989 Coming Together • Peruvian Paradisehttps://digitalcommons.ursinus.edu/grizzlynews/1230/thumbnail.jp

The Grizzly, November 9, 1987

proTheatre Perfects Production • Balloon Bombings Banned • Norman Pearlstine Addresses Problems Associated with the U.S. Free Press • Letters: Beautifying Campus?; In One Ear, Out the Other • Rolling Stone Celebrates 20th Year • Iran Source of Conflict in Dialogue Discussion • Calix Relates Salvadorian Horrors • Notes: Room Policy Changed; Apartheid Subject of Forum; Discussion Includes Pretzels!; Myths to be Explained • Ursinus Not Affected by Stock Market Crash: Others Not as Lucky • Pray TV Damages Churches • UC Robs Team of Championship • Error Prone Bears Drop Another • Early Bowl Picture Thickens • Bears Battle Tough Season • Ursinus \u27Mers Open Season • Bear Pack Finishes Strong • Tri Lambda: Organization for Life Long Learners • Musser: The Year After • Get in The Real World Get the Grizzly Network • Busie Bodys Display Fancy Bodies • Welcome to the Greek Life: Congratulations 1987 Pledges • Phonathons Prove Successful: $30,000 Raised • Student Applauds Washington Semester • Seniors: Where Are You? • November Red and Gold Days • Eshbach Awards Winners • CAB Learns New Ideas • New Equipment Upgrades Dept.https://digitalcommons.ursinus.edu/grizzlynews/1198/thumbnail.jp

The Grizzly, December 1, 1989

Curriculum in Transition • Armstrong\u27s Talk a Trauma • Letters: Maturity Decides Right Choice; Everybody\u27s a Critic; Championship Cycling; PDA Pooh-Poohed; Pro-Choice Rally Ironic • Aquatic Lady Bears Stroke Strongly • Hoopsters Hopeful • Women\u27s Track Looks to Season • Congrats to Athletes • Shoudt to Return Next Fall • X-Country Wrap-Up • Swimmers Victorious • Down with Frats • Faith-Leaps Abound • EPA: Not a Joking Matter • What Can Clamer Claim? • Victims of Fishy Business • Corsonites Fashion Comatose • Greeks Promote Sexism • U.C. Honors Spotlight • Final Exam Schedulehttps://digitalcommons.ursinus.edu/grizzlynews/1248/thumbnail.jp

The Grizzly, December 3, 1990

Wismer Hall to be Renovated by Next Fall • Quad Intruder Returns • Politics Honors Projects • Foreign Policy and the Press • Ursinus Offers St. Joseph\u27s Post-MBA Certificates • Dance Marathon Planned • Crazy Toys • Holiday Messages Encouraged • Exam Schedule • Mixed Up • Jane\u27s Addiction Concert Review • European Old Master Prints • At the Playhouse • Attention Skiers • Edie Brickell Reviewed • In the Spotlight • Swimmers Host Double-Header Weekend • Lady Hoopsters Shoot for Title • Are We Going to War? • Why are We Really There? • Hey! Who\u27s the New Guy? • Brain in Brief • Bonnie and SAM (not Clyde)https://digitalcommons.ursinus.edu/grizzlynews/1266/thumbnail.jp

The Grizzly, November 6, 1990

Olin Hall Dedicated: First New Building In 20 Years • Founder\u27s Day Celebrated • Quad Intruder Sighted • Graff Speaks on Humanities Issues • Woodall Recognized • Olin: Past and Present • Sportscaster Dabbles in Theatre • Capitol Trip a Success • A WVOU Profile: Quickdraw Throws Rap at Ursinus • Warrant: A Bunch of Sissies • Ursinus Theatre: The Changeling • Hey Bar Hoppers! • Meier Named Ursinus\u27 New Lacrosse Coach • Soccer Ends Season with 9-11 Record • Field Hockey Finishes Season • Women Swim to Win, Men Sink • Cross-Country Team Reflects on MAC\u27s • Volleyball Wraps-Up • Wrestlers Look to Impress • Letters: Zeta Chi Sexist?; Students Waste Money • Olin Has Great Benefits • Voting Guide • Moon Mystifieshttps://digitalcommons.ursinus.edu/grizzlynews/1263/thumbnail.jp