Maternal Expression Relaxes Constraint on Innovation of the Anterior Determinant, bicoid

The origin of evolutionary novelty is believed to involve both positive selection and relaxed developmental constraint. In flies, the redesign of anterior patterning during embryogenesis is a major developmental innovation and the rapidly evolving Hox gene, bicoid (bcd), plays a critical role. We report evidence for relaxation of selective constraint acting on bicoid as a result of its maternal pattern of gene expression. Evolutionary theory predicts 2-fold greater sequence diversity for maternal effect genes than for zygotically expressed genes, because natural selection is only half as effective acting on autosomal genes expressed in one sex as it is on genes expressed in both sexes. We sample an individual from ten populations of Drosophila melanogaster and nine populations of D. simulans for polymorphism in the tandem gene duplicates bcd, which is maternally expressed, and zerknüllt (zen), which is zygotically expressed. In both species, we find the ratio of bcd to zen nucleotide diversity to be two or more in the coding regions but one in the noncoding regions, providing the first quantitative support for the theoretical prediction of relaxed selective constraint on maternal-effect genes resulting from sex-limited expression. Our results suggest that the accelerated rate of evolution observed for bcd is owing, at least partly, to variation generated by relaxed selective constraint

Etch Induced Microwave Losses in Titanium Nitride Superconducting Resonators

We have investigated the correlation between the microwave loss and patterning method for coplanar waveguide titanium nitride resonators fabricated on Si wafers. Three different methods were investigated: fluorine- and chlorine-based reactive ion etches and an argon-ion mill. At high microwave probe powers the reactive etched resonators showed low internal loss, whereas the ion-milled samples showed dramatically higher loss. At single-photon powers we found that the fluorine-etched resonators exhibited substantially lower loss than the chlorine-etched ones. We interpret the results by use of numerically calculated filling factors and find that the silicon surface exhibits a higher loss when chlorine-etched than when fluorine-etched. We also find from microscopy that re-deposition of silicon onto the photoresist and side walls is the probable cause for the high loss observed for the ion-milled resonator

Spectroscopic Confirmation of Three Redshift 5.7 Lyman-alpha Emitters from the Large Area Lyman Alpha Survey

Narrow-band searches for Lyman alpha emission are an efficient way of identifying star-forming galaxies at high redshifts. We present Keck telescope spectra confirming redshifts z = 5.7 for three objects discovered in the Large Area Lyman Alpha (LALA) survey at Kitt Peak National Observatory. All three spectra show strong, narrow emission lines with the asymmetric profile that is characteristically produced in high redshift Lyman alpha emitters by preferential HI absorption in the blue wing of the line. These objects are undetected in deep Bw, V, R, and 6600A narrow-band images from the NOAO Deep Wide-Field Survey and from LALA, as expected from Lyman break and Lyman alpha forest absorption at redshift z = 5.7. All three objects show large equivalent widths (>= 150A in the rest-frame), suggesting at least one of the following: a top-heavy initial mass function, very low stellar metallicity, or the presence of an active nucleus. We consider the case for an active nucleus to be weak in all three objects due to the limited width of the Lyman alpha emission line (< 500 km/s) and the absence of any other indicator of quasar activity. The three confirmed high redshift objects were among four spectroscopically observed targets drawn from the sample of 18 candidates presented by Rhoads and Malhotra (2001). Thus, these spectra support the Lyman alpha emitter population statistics from our earlier photometric study, which imply little evolution in number density from z=5.7 to z=4.5 and provide strong evidence that the reionization redshift is greater than 5.7.Comment: Submitted to AJ, June 2002. 15 pages, AASTe

The behavioural wedge

When nations fail to agree, can individual citizens make a difference? The third of our post-Copenhagen features is by Jonathan Gilligan, Thomas Dietz, Gerald T. Gardner, Paul C. Stern , and Michael P. Vandenbergh . They look at the effects that voluntary actions by individuals can have, and at the policies that can best encourage such actions.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79202/1/j.1740-9713.2010.00405.x.pd

Energy and Climate Change: Key Lessons for Implementing the Behavioral Wedge

The individual and household sector accounts for roughly 40 percent of United States energy use and carbon dioxide emissions, yet the laws and policies directed at reductions from this sector often reflect a remarkably simplistic model of behavior. This Essay addresses one of the obstacles to achieving a “behavioral wedge” of individual and household emissions reductions: the lack of an accessible, brief summary for policymakers of the key findings of behavioral and social science studies on household energy behavior. The Essay does not provide a comprehensive overview of the field, but it discusses many of the leading studies that demonstrate the extent and limits of rational action. These studies can inform lawyers and policymakers who are developing measures to reduce energy use and carbon emissions and can serve as an entry point for more detailed studies of the literature. An effective response to the climate change problem will require substantial reductions in energy demand in addition to new developments in low-carbon energy supplies. The individual and household sector presents a major opportunity: the sector accounts for roughly 40% of U.S. carbon emissions and a comparable percentage of total U.S. energy production, and it is one of the most promising areas for reducing emissions. A recent analysis estimates that behavioral measures directed at this sector could reasonably be expected to reduce total US emissions by over 7% by 2020, an amount larger than the combined emissions from several of the largest-emitting industrial sectors and larger than the total emissions of France. In many cases, these emissions reductions can be achieved at less cost than the leading alternatives. Despite this opportunity, recent regulatory and policy efforts are only beginning to direct substantial attention to the individual and household sector. Findings from the social sciences provide valuable insights into how to capitalize on this opportunity, yet policymakers often have little time to develop new polices and are confronted with a barrage of often-conflicting approaches and theories. This Essay addresses the policy-making challenge by distilling the findings from a broad range of fields into several key principles for those developing energy and climate laws and policies. The principles we outline here are a starting point for policymakers working in this area. We attempt to provide insight into which principles are most relevant to law and policy, but instructions as to how to incorporate these principles are beyond the scope of this essay. The principles include only a subset of the insights from the behavioral and social science literature. In many cases, adherence to multiple principles will be necessary to develop the most effective policy design. Policymakers should consult the body of work referenced here, as well as experts in the social sciences to further their understanding of these and other principles. More extensive reviews of this literature and its relevance to energy and climate policy are also available

Discovery of a 500 pc shell in the nucleus of Centaurus A

Spitzer Space Telescope mid-infrared images of the radio galaxy Centaurus A reveal a shell-like, bipolar, structure 500 pc to the north and south of the nucleus. This shell is seen in 5.8, 8.0 and 24 micron broad-band images. Such a remarkable shell has not been previously detected in a radio galaxy and is the first extragalactic nuclear shell detected at mid-infrared wavelengths. We estimate that the shell is a few million years old and has a mass of order million solar masses. A conservative estimate for the mechanical energy in the wind driven bubble is 10^53 erg. The shell could have created by a small few thousand solar mass nuclear burst of star formation. Alternatively, the bolometric luminosity of the active nucleus is sufficiently large that it could power the shell. Constraints on the shell's velocity are lacking. However, if the shell is moving at 1000 km/s then the required mechanical energy would be 100 times larger.Comment: submitted to ApJ Letter

Strong enhancement of drag and dissipation at the weak- to strong- coupling phase transition in a bi-layer system at a total Landau level filling nu=1

We consider a bi-layer electronic system at a total Landau level filling factor nu =1, and focus on the transition from the regime of weak inter-layer coupling to that of the strongly coupled (1,1,1) phase (or ''quantum Hall ferromagnet''). Making the assumption that in the transition region the system is made of puddles of the (1,1,1) phase embedded in a bulk of the weakly coupled state, we show that the transition is accompanied by a strong increase in longitudinal Coulomb drag, that reaches a maximum of approximately $h/2e^{2}$. In that regime the longitudinal drag is increased with decreasing temperature.Comment: four pages, one included figur

Skin Lesion Analyser: An Efficient Seven-Way Multi-Class Skin Cancer Classification Using MobileNet

Skin cancer, a major form of cancer, is a critical public health problem with 123,000 newly diagnosed melanoma cases and between 2 and 3 million non-melanoma cases worldwide each year. The leading cause of skin cancer is high exposure of skin cells to UV radiation, which can damage the DNA inside skin cells leading to uncontrolled growth of skin cells. Skin cancer is primarily diagnosed visually employing clinical screening, a biopsy, dermoscopic analysis, and histopathological examination. It has been demonstrated that the dermoscopic analysis in the hands of inexperienced dermatologists may cause a reduction in diagnostic accuracy. Early detection and screening of skin cancer have the potential to reduce mortality and morbidity. Previous studies have shown Deep Learning ability to perform better than human experts in several visual recognition tasks. In this paper, we propose an efficient seven-way automated multi-class skin cancer classification system having performance comparable with expert dermatologists. We used a pretrained MobileNet model to train over HAM10000 dataset using transfer learning. The model classifies skin lesion image with a categorical accuracy of 83.1 percent, top2 accuracy of 91.36 percent and top3 accuracy of 95.34 percent. The weighted average of precision, recall, and f1-score were found to be 0.89, 0.83, and 0.83 respectively. The model has been deployed as a web application for public use at (https://saketchaturvedi.github.io). This fast, expansible method holds the potential for substantial clinical impact, including broadening the scope of primary care practice and augmenting clinical decision-making for dermatology specialists.Comment: This is a pre-copyedited version of a contribution published in Advances in Intelligent Systems and Computing, Hassanien A., Bhatnagar R., Darwish A. (eds) published by Chaturvedi S.S., Gupta K., Prasad P.S. The definitive authentication version is available online via https://doi.org/10.1007/978-981-15-3383-9_1

Polymorphism of the 3′-Untranslated Region of the Leptin Receptor Gene, but Not the Adiponectin <i>SNP45</i> Polymorphism, Predicts Type 2 Diabetes

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