18F-FDG PET/MRI Imaging in a Preclinical Rat Model of Cardiorenal Syndrome—An Exploratory Study

Cardiorenal syndrome (CRS) denotes the bidirectional interaction of chronic kidney disease and heart failure with an adverse prognosis but with a limited understanding of its pathogenesis. This study correlates biochemical blood markers, histopathological and immunohistochemistry features, and 2-deoxy-2-fluoro-D-glucose positron emission tomography (18F-FDG PET) metabolic data in low-dose doxorubicin-induced heart failure, cardiorenal syndrome, and renocardiac syndrome induced on Wistar male rats. To our knowledge, this is the first study that investigates the underlying mechanisms for CRS progression in rats using 18F-FDG PET. Clinical, metabolic cage monitoring, biochemistry, histopathology, and immunohistochemistry combined with PET/MRI (magnetic resonance imaging) data acquisition at distinct points in the disease progression were employed for this study in order to elucidate the available evidence of organ crosstalk between the heart and kidneys. In our CRS model, we found that chronic treatment with low-dose doxorubicin followed by acute 5/6 nephrectomy incurred the highest mortality among the study groups, while the model for renocardiac syndrome resulted in moderate-to-high mortality. 18F-FDG PET imaging evidenced the doxorubicin cardiotoxicity with vascular alterations, normal kidney development damage, and impaired function. Given the fact that standard clinical markers were insensitive to early renal injury, we believe that the decreasing values of the 18F-FDG PET-derived renal marker across the groups and, compared with their age-matched controls, along with the uniform distribution seen in healthy developing rats, could have a potential diagnostic and prognostic yield in cardiorenal syndrome

Conjunctural Trends in the Evolution of European and International Trade Legislation during the Post-Crisis Period

This paper aims at identifying the advantages and disadvantages of Romania in trade, in the context of profound structural changes in global and EU, on this basis, making recommendations and proposals for macroeconomic and microeconomic policy makers. Thus, on one hand, we have developed promotional policy proposals designed to support decision makers in our country, and on the other hand, proposals for business, so based on their Romanian exporters to eliminate weaknesses and to face the competition, both domestic and extra markets. Another major objective of the study was to formulate recommendations "of targeted" sectors with high export potential, given the directions for the period 2012-2016

Study on Nutritional Potential of Trees and Complementary Food during Winter-Spring, Summer-Autumn in Hunting Fund no.20 Higeg

This paper presents the calculation of complementary food needs for animal species, which live in the hunting fund no.20 Higeg. This calculation is absolutely necessary to be predetermined and properly distributed, so that in winter, the animals have required amount of food to survive, in order to develop and reproduce normally. Supplementary food is given only in winter, especially when snow prevents hunting to feed. Complementary food comes, as the name implies, to complement the very poor diet of the animals. The amount of complementary food is based on its quality of each species

Study of Hunting Spread in Winter-Spring, Calculation of Necessity of Food and Comparison with the Potential Natural Food in the Hunting Fund no.3 Borlova

Hunting fund no.3 Borlova is a fund with a large surface area and its species of concern, especially bears and chamois. To ensure their coexistence conditions and breeding are absolutely necessary studies of relevance game in the winter-spring food calculation and comparison of potential natural food, and so we thought we'd do such a study and we present in this work

The Impact of the Communitarian Commercial Policy in Romanian Foreign Trade

This study considers that both development and implementation of EU external trade policy were strongly determined by the fact that this policy was part of the very process of economic integration. If a common trade policy is the first step of a common economic policy, it can only be a means to achieve long-term agreements. Due to this aspect, this paper considers that the Communitarian Commercial Policy (CCP) should not be understood or addressed as an end in itself but as one means and even one of the most important ways to ensure the accelerated development and concerted economic and monetary unification process in the EU. Moreover, this concept promoter, namely “European construction”, achieving CCP has symbolic value because it is thought that once done, it triggers “chain reactions” of integration’ developments and “irreversibility points”

The Study of Hunting Spread in Winter-Spring, Calculation of Necessity of Food and Comparison with the Potential Natural Food in the Hunting Fund no.20 Higeg

Hunting fund no.20 Higeg is a fund with a large surface area and its species of concern, especially bears and chamois. To ensure their coexistence conditions and breeding are absolutely necessary studies of relevance game in the winter-spring food calculation and comparison of potential natural food, and so we thought we'd do such a study and we present in this work

Calculation of Complementary Food for Species of Wild Animals of the Hunting Fund no.61 Crocna-Zimbru

This paper presents the calculation of complementary food needs for animal species, which live in the hunting fund no.61 Crocna-Zimbru. This calculation is absolutely necessary to be predetermined and properly distributed, so that in winter, the animals have required amount of food to survive, in order to develop and reproduce normally. Supplementary food is given only in winter, especially when snow prevents hunting to feed. Complementary food comes, as the name implies, to complement the very poor diet of the animals. The amount of complementary food is based on its quality of each species

Geophysical and geochemical investigations of underwater sulphurous seeps from Western Black Sea (Mangalia area, Romania), in support of habitat conservation

Mangalia area harbors in the western Black Sea a distinctive marine environment thriving under specific hydrochemical conditions, largely influenced by a significant number of sulphurous springs occurring in shallow marine waters. These springs led to the designation of the area as part of the Natura 2000 Marine Protected Area (MPA) network at European level (Underwater Sulphurous Springs from Mangalia - ROSAC0094), as unique hydro-geomorphological features in the region. In 2021 and 2023, two research cruises led by GeoEcoMar investigated underwater sulphurous springs primarily located offshore of Mangalia (Constanţa County, Romania). The study area, located between 17-29 meters water depth and 1.8-3 km offshore, encompasses two marine protected areas: the Underwater Sulphurous Springs from Mangalia (ROSAC0094) and Cape Aurora (ROSCI0281). The research combined geophysical and geochemical techniques and sediment sampling. Considering the susceptibility of these natural systems to human activities such as fishing and dredging, as well as the impact of ecological and climate changes, this paper offers significant insights contributing to the development of effective conservation and management strategies for these environments. The surveys were conducted for benthic habitats mapping, with the objective of improving our understanding of these ecosystems’ distribution, composition and dynamics. As these sulphurous waters are rich in methane, a powerful greenhouse gas, our results also contribute to the inventory of greenhouse gas sources. The results presented in this paper provide valuable new insights into this specific environment, contributing to the understanding of its complex functioning and evolution