7 research outputs found

    Integrated techno-economic analysis and life cycle assessment of emerging technologies with temporal resolution

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    2020 Fall.Includes bibliographical references.Techno-economic analysis (TEA) and life cycle assessment (LCA) are analytical tools used to quantify the economic and environmental performance of emerging technologies. TEA and LCA help guide the development of these technologies by identifying areas where additional research will significantly reduce economic costs and environmental impacts. Although often used in tandem, TEA and LCA output separate results that rely upon disconnected metrics. When considering the impact of time, the disconnect between TEA and LCA methods is critical and can significantly impact results. In this dissertation, three phases of research are conducted to illustrate and reconcile the disconnect between TEA and LCA. In the first phase, standard TEA and LCA methods are used to evaluate the economic and environmental performance of natural rubber derived from guayule (Parthenium argentatum). This evaluation is used to identify the strengths and weaknesses of interpreting disconnected TEA and LCA results. In the second phase, two new methods are created to overcome this disconnect by integrating temporally resolved TEA and LCA. These methods are applied to electric power and guayule rubber production to highlight the impacts of integrating temporally resolved TEA and LCA. In the third phase, integrated TEA and LCA is used to perform a deep-dive evaluation on low-emissions technology options for natural gas combined cycle power plants. In this phase, TEA and LCA with temporal resolution are used to identify cost targets for biomethane, carbon capture and storage (CCS), and bioenergy with CCS (BECCS) under different emissions pricing scenarios. Taken together, the three phases of research in this dissertation represent a wide range of applications and methodologies, each with varying objectives and complexity. Understanding the details of these approaches will help guide future analysis where economic costs, environmental impacts, and time are important considerations in technological development

    Analyse des 3D-Faserspritzverfahrens zur Fertigung komplexer und funktionsintegrierter RTM-Strukturbauteile

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    Figure S3. Trends in peripheral lymphocyte numbers and percentages over time on treatment. Significant decreases in mean peripheral lymphocyte numbers (left panel, p = 0.007) and percentages (right panel, p = 0.018) occurred over time on treatment and follow-up. Linear mixed effect model was used for comparisons. Mean values, represented by solid circles, are connected by a trendline in each graph. Rectangles at each time point extend to the 1st and 3rd quartiles. Vertical lines at each time point extend to 1.5 x the interquartile range. Dashed lines indicate upper and lower limits of normal values. Each treatment cycle length is 28 days. Samples were obtained on Day 1 of each cycle for patients in Cohorts A and B, and on Day 0 of each cycle for patients in Cohort C. An analysis including all patients is shown. Similar trends were seen for each cohort when analyzed individually (data not shown). C, treatment cycle

    Additional file 1: of Safety and immunologic correlates of Melanoma GVAX, a GM-CSF secreting allogeneic melanoma cell vaccine administered in the adjuvant setting

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    Figure S1. Schedule of Melanoma GVAX treatment, biospecimen collection and clinical assessment. Asterisks denote vaccine administration (Day 1 of each cycle). Cyclophosphamide was administered one day prior to each vaccine administration for patients in cohort C. Peripheral blood (PB) was collected at baseline (C1D1, or C1D0 for Cohort C) and prior to each vaccination [C2D1(D0), C3D1(D0) and C4D1(D0)], Treatment cycle length is 28 days. C, treatment cycle; D, treatment day
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