Don\u27t wait for them to come to you: Partnering with student support services

This poster discusses: Inquiry Question, Methodology, Results, Key Findings from the Literature, and Conclusions

Differences between Male and Female Welding Students’ Tinkering Self-Efficacy

Welding, agricultural mechanics and blue-collar trades have traditionally been perceived to be reserved for males, yet many females in recent years have enrolled in training programs and have entered these careers (England, 2010). In previous research, females have indicated lower levels of tinkering self-efficacy and confidence in mechanics settings (Baker & Krause, 2007). This study examined difference between male and female welding student’s perceptions of welding technology, tinkering self-efficacy, and perceptions of learning welding technology. Students were engaged in designated tinkering activities throughout the semester to promote developing tinkering abilities. Activities included but were not limited to GMAW and SMAW break tests, amperage and wire feed speed tests, utilizing Torchmate CAD software, and soldering copper pipes. Students completed a pre-survey and post-survey for researchers to determine differences in their perceptions of welding technology, tinkering self-efficacy, and perceptions of learning welding technology throughout the semester. The female students consistently indicated lower levels of tinkering self-efficacy in the welding setting compared to their male counterparts. Neither the female nor male welding student’s tinkering self-efficacy increased throughout the semester. We recommend additional research to be conducted to determine the specific factors which increase or decrease an individual’s tinkering self-efficacy. We also recommend educators and industry professionals consider gender stereotypes and be aware that females entering welding careers may potentially have lower tinkering self-efficacy levels compared to their male counterparts

Automatic Detection of Cortical Arousals in Sleep and their Contribution to Daytime Sleepiness

Cortical arousals are transient events of disturbed sleep that occur spontaneously or in response to stimuli such as apneic events. The gold standard for arousal detection in human polysomnographic recordings (PSGs) is manual annotation by expert human scorers, a method with significant interscorer variability. In this study, we developed an automated method, the Multimodal Arousal Detector (MAD), to detect arousals using deep learning methods. The MAD was trained on 2,889 PSGs to detect both cortical arousals and wakefulness in 1 second intervals. Furthermore, the relationship between MAD-predicted labels on PSGs and next day mean sleep latency (MSL) on a multiple sleep latency test (MSLT), a reflection of daytime sleepiness, was analyzed in 1447 MSLT instances in 873 subjects. In a dataset of 1,026 PSGs, the MAD achieved a F1 score of 0.76 for arousal detection, while wakefulness was predicted with an accuracy of 0.95. In 60 PSGs scored by multiple human expert technicians, the MAD significantly outperformed the average human scorer for arousal detection with a difference in F1 score of 0.09. After controlling for other known covariates, a doubling of the arousal index was associated with an average decrease in MSL of 40 seconds ($\beta$ = -0.67, p = 0.0075). The MAD outperformed the average human expert and the MAD-predicted arousals were shown to be significant predictors of MSL, which demonstrate clinical validity the MAD.Comment: 40 pages, 13 figures, 9 table

Temporal scaling phenomena in groundwater-floodplain systems using robust detrended fluctuation analysis

In order to determine objectively the fractal behaviour of a time series, and to facilitate potential future attempts to assess model performance by incorporating fractal behaviour, a multi-order robust detrended fluctuation analysis (r-DFAn) procedure is developed herein. The r-DFAn procedure allows for robust and automated quantification of mono-fractal behaviour. The fractal behaviour is quantified with three parts: a global scaling exponent, crossovers, and local scaling exponents. The robustness of the r-DFAn procedure is established by the systematic use of robust regression, piecewise linear regression, Analysis of Covariance (ANCOVA) and Multiple Comparison Procedure to determine statistically significant scaling exponents and optimum crossover locations. The MATLAB code implementing the r-DFAn procedure has also been open sourced to enable reproducible results. r-DFAn will be illustrated on a synthetic signal after which is used to analyse high-resolution hydrologic data; although the r-DFAn procedure is not limited to hydrological or geophysical time series. The hydrological data are 4 year-long datasets (January 2012 to January 2016) of 1-min groundwater level, river stage, groundwater and river temperature, and 15-min precipitation and air temperature, at Wallingford, UK. The datasets are analysed in both time and fractal domains. The study area is a shallow riparian aquifer in hydraulic connection to River Thames, which traverses the site. The unusually high resolution datasets, along with the responsive nature of the aquifer, enable detailed examination of the various data and their interconnections in both time- and fractal-domains

Exacerbation of adverse cardiovascular effects of aircraft noise in an animal model of arterial hypertension

Arterial hypertension is the most important risk factor for the development of cardiovascular disease. Recently, aircraft noise has been shown to be associated with elevated blood pressure, endothelial dysfunction, and oxidative stress. Here, we investigated the potential exacerbated cardiovascular effects of aircraft noise in combination with experimental arterial hypertension. C57BL/6J mice were infused with 0.5 mg/kg/d of angiotensin II for 7 days, exposed to aircraft noise for 7 days at a maximum sound pressure level of 85 dB(A) and a mean sound pressure level of 72 dB(A), or subjected to both stressors. Noise and angiotensin II increased blood pressure, endothelial dysfunction, oxidative stress and inflammation in aortic, cardiac and/or cerebral tissues in single exposure models. In mice subjected to both stressors, most of these risk factors showed potentiated adverse changes. We also found that mice exposed to both noise and ATII had increased phagocytic NADPH oxidase (NOX-2)-mediated superoxide formation, immune cell infiltration (monocytes, neutrophils and T cells) in the aortic wall, astrocyte activation in the brain, enhanced cytokine signaling, and subsequent vascular and cerebral oxidative stress. Exaggerated renal stress response was also observed. In summary, our results show an enhanced adverse cardiovascular effect between environmental noise exposure and arterial hypertension, which is mainly triggered by vascular inflammation and oxidative stress. Mechanistically, noise potentiates neuroinflammation and cerebral oxidative stress, which may be a potential link between both risk factors. The results indicate that a combination of classical (arterial hypertension) and novel (noise exposure) risk factors may be deleterious for cardiovascular health

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation

In mammals, the ATM (ataxia-telangiectasia-mutated) and ATR (ATM and Rad3-related) protein kinases function as critical regulators of the cellular DNA damage response. The checkpoint functions of ATR and ATM are mediated, in part, by a pair of checkpoint effector kinases termed Chk1 and Chk2. In mammalian cells, evidence has been presented that Chk1 is devoted to the ATR signaling pathway and is modified by ATR in response to replication inhibition and UV-induced damage, whereas Chk2 functions primarily through ATM in response to ionizing radiation (IR), suggesting that Chk2 and Chk1 might have evolved to channel the DNA damage signal from ATM and ATR, respectively. We demonstrate here that the ATR-Chk1 and ATM-Chk2 pathways are not parallel branches of the DNA damage response pathway but instead show a high degree of cross-talk and connectivity. ATM does in fact signal to Chk1 in response to IR. Phosphorylation of Chk1 on Ser-317 in response to IR is ATM-dependent. We also show that functional NBS1 is required for phosphorylation of Chk1, indicating that NES1 might facilitate the access of Chk1 to ATM at the sites of DNA damage. Abrogation of Chk1 expression by RNA interference resulted in defects in IR-induced S and G2/M phase checkpoints; however, the overexpression of phosphorylation site mutant (S317A, S345A or S317A/S345A double mutant) Chk1 failed to interfere with these checkpoints. Surprisingly, the kinase-dead Chk1 (D130A) also failed to abrogate the S and G2 checkpoint through any obvious dominant negative effect toward endogenous Chk1. Therefore, further studies will be required to assess the contribution made by phosphorylation events to Chk1 regulation. Overall, the data presented in the study challenge the model in which Chk1 only functions downstream from ATR and indicate that ATM does signal to Chk1. In addition, this study also demonstrates that Chk1 is essential for IR-induced inhibition of DNA synthesis and the G2/M checkpoint

The reporting of studies conducted using observational routinely collected health data statement for pharmacoepidemiology (RECORD-PE).

In pharmacoepidemiology, routinely collected data from electronic health records (including primary care databases, registries, and administrative healthcare claims) are a resource for research evaluating the real world effectiveness and safety of medicines. Currently available guidelines for the reporting of research using non-randomised, routinely collected data - specifically the REporting of studies Conducted using Observational Routinely collected health Data (RECORD) and the Strengthening the Reporting of OBservational studies in Epidemiology (STROBE) statements - do not capture the complexity of pharmacoepidemiological research. We have therefore extended the RECORD statement to include reporting guidelines specific to pharmacoepidemiological research (RECORD-PE). This article includes the RECORD-PE checklist (also available on www.record-statement.org) and explains each checklist item with examples of good reporting. We anticipate that increasing use of the RECORD-PE guidelines by researchers and endorsement and adherence by journal editors will improve the standards of reporting of pharmacoepidemiological research undertaken using routinely collected data. This improved transparency will benefit the research community, patient care, and ultimately improve public health

Gerinnungsveränderungen unter In-vitro-Fertilisationstherapie

Unterschiedliche Hormonpräparate, wie beispielsweise orale Kontrazeptiva oder Substitutionspräparate in der Menopause sind in den letzten Jahren vermehrt in die Schlagzeilen geraten. Es wurden viele Studien veröffentlicht, die zeigten, daß es unter bestimmten Hormongaben zu Veränderungen der Blutgerinnung kommt im Sinne von Steigerung des pro- bzw. Reduktion des antikoagulatorischen Potentials. Somit besteht ein erhöhtes Thromboserisiko unter Verwendung bestimmter Hormonpräparate, insbesondere, wenn weitere Risikofaktoren für thromboembolische Ereignisse (Rauchen, Adipositas, Immobilisation usw.) hinzu kommen. Da die In-vitro-Fertilisation in den letzten 20 Jahren immer mehr an Bedeutung gewonnen hat und während eines IVF-Zyklus Hormone in hoher Dosierung verabreicht werden, stellte sich die Frage, ob und inwieweit es auch hier zu Gerinnungsveränderungen kommt. In der vorliegenden Arbeit konnten wir anhand unterschiedlicher Gerinnungs-parameter und Hormonwertbestimmungen bei zwei unterschiedlichen IVF-Stimu-lations-Protokollen zeigen, daß es unter In-vitro-Fertilisations-Therapie zu Veränderungen der Blutgerinnung der Patientinnen kommt. In beiden von uns untersuchten Patientengruppen (LONG- versus SHORT-Protokoll Programm) wiesen sowohl die Globaltests der plasmatischen Gerinnung (Quick-Wert, aPTT und Fibrinogen) als auch die Gerinnungsaktivierungsparameter Prothrombinfragment F1+2 und D-Dimer auf eine Erhöhung des prokoagulatorischen Potentials bzw. eine Gerinnungsaktivierung hin. Die in den letzten Jahren auf dem Gebiet der Gerinnungsaktivierung bzw. -inhibierung erst genauer erforschten Faktoren Tissue factor und Tissue factor pathway inhibitor verhielten sich unterschiedlich in den beiden von uns untersuchten Gruppen und zeigten keine eindeutig signifikanten Veränderungen. In bezug auf die Hormonwertveränderungen unter IVF-Therapie konnten wir zeigen, daß die Gerinnungswerte, insbesondere Prothrombinfragment F1+2 und D-Dimer, der Patientinnen beider Protokolle signifikant mit den Progesteron-Werten korrelierten. Estrogen-Spiegel scheinen dagegen bei der In-vitro-Fertilisations-Hormontherapie eine untergeordnete Rolle zu spielen in bezug auf die Gerinnungsaktivierung. Zwischen den beiden Patientengruppen bestanden kaum Unterschiede hinsichtlich Ansteigen bzw. Abfallen der einzelnen Parameter. Lediglich in bezug auf die Höhe des jeweiligen Anstiegs bzw. Abfalls konnte gezeigt werden, daß, außer bei den F 1+2-Werten, jeweils die Endwerte der Patientinnen der LONG-Protokoll Gruppe deutlich über bzw. unter denen der SHORT-Protokoll Gruppe lagen, was auf ein stärkeres Ansteigen des prokoagulatorischen Potentials in diesem Protokoll weist, insbesondere im Zusammenhang mit dem auch in dieser Gruppe stärkeren Ansteigen des Progesterons

Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016

Azimuthal anisotropy of charged jet production in root s(NN)=2.76 TeV Pb-Pb collisions

We present measurements of the azimuthal dependence of charged jet production in central and semi-central root s(NN) = 2.76 TeV Pb-Pb collisions with respect to the second harmonic event plane, quantified as nu(ch)(2) (jet). Jet finding is performed employing the anti-k(T) algorithm with a resolution parameter R = 0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy of the underlying event is taken into account event-by-event. The remaining (statistical) region-to-region fluctuations are removed on an ensemble basis by unfolding the jet spectra for different event plane orientations independently. Significant non-zero nu(ch)(2) (jet) is observed in semi-central collisions (30-50% centrality) for 20 <p(T)(ch) (jet) <90 GeV/c. The azimuthal dependence of the charged jet production is similar to the dependence observed for jets comprising both charged and neutral fragments, and compatible with measurements of the nu(2) of single charged particles at high p(T). Good agreement between the data and predictions from JEWEL, an event generator simulating parton shower evolution in the presence of a dense QCD medium, is found in semi-central collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe