Royal jelly accelerates healing of acetate induced gastric ulcers in male Rats

Aim: This study examined the healing potential of royal jelly on the acetic acid induced wounds healing in male rat’s gastric mucosa. Background: Scientific reports suggest that, bee products can help in the wounds healing. Methods: 96 adult male Wistar rats were divided into in 4 groups as follows: control, omeprazole 20 mg/kg, and royal jelly 50 and 200 mg/kg). Wound was induced in stomach mucosa of each rat with 100% acetic acid. Samples groups received omeprazole or royal jelly from 1st to 14th day after acetic ulcer induction. Gastric ulcer healing and histopathological parameters were evaluated on 4, 7, 10, 15th days after ulceration. Both descriptive and statistical analyses were used. P <0.05 was considered as significant. Results: The royal jelly administration significantly reduced the depth of lesion in comparison with the control group (p<0.05) and attuned histopathological changes in the treatment groups. The largest healing effect was demonstrated with royal jelly on 10th treatment day, at a higher concentration (200 mg/kg). Conclusion: These findings supported that royal jelly had effectively contributed to the wound healing, valid gastroprotective activity, and can be used for peptic ulcer therapy. Keywords: Royal jelly, Gastric ulcer, Ra

Royal jelly accelerates healing of acetate induced gastric ulcers in male rats

Aim: This study examined the healing potential of royal jelly on the acetic acid induced wounds healing in male rat’s gastric mucosa. Background: Scientific reports suggest that, bee products can help in the wounds healing. Methods: 96 adult male Wistar rats were divided into in 4 groups as follows: control, omeprazole 20 mg/kg, and royal jelly 50 and 200 mg/kg). Wound was induced in stomach mucosa of each rat with 100% acetic acid. Samples groups received omeprazole or royal jelly from 1st to 14th day after acetic ulcer induction. Gastric ulcer healing and histopathological parameters were evaluated on 4, 7, 10, 15th days after ulceration. Both descriptive and statistical analyses were used. P <0.05 was considered as significant. Results: The royal jelly administration significantly reduced the depth of lesion in comparison with the control group (p<0.05) and attuned histopathological changes in the treatment groups. The largest healing effect was demonstrated with royal jelly on 10th treatment day, at a higher concentration (200 mg/kg). Conclusion: These findings supported that royal jelly had effectively contributed to the wound healing, valid gastroprotective activity, and can be used for peptic ulcer therapy

Association between hypertension and insulin resistance in non-diabetic adult populations: a community-based study from the Iran

Background and objectives: High blood pressure increases the probability of insulin resistance and hyperinsulinemia. Also, insulin resistance can be defined as a risk factor for hypertension. The present study investigated the relationship between hypertension and insulin resistance in non-diabetic participants who were referred to Qazvin Metabolic Diseases Center. Material and methods: In this cross sectional study, 1103 participants (111 non-diabetic with newly diagnosed hypertension and 992 normotensive subjects aged ≥ 20 years) were enrolled from September 2014 to April 2016 in Qazvin (Iran). Systolic and diastolic blood pressure, insulin resistance, waist circumference, body mass index, triglycerides, cholesterol, LDL-cholesterol, fasting blood glucose (FBG) were measured. Fasting triglyceride to highdensity lipoprotein cholesterol ratio (TG/HDL-C) was used as a surrogate of insulin resistance. Data were analyzed using SPSS software and p &lt; 0.05 was assumed as significant level. Results: Ten percent of all participants had hypertension. TG/HDL-C was 3.78 ± 3.28 in non-HTN and 5.76 ± 5.35 in HTN participants (p &lt; 0.001). The frequency of all cardio-metabolic risk factors (except HDL cholesterol level) was higher in hypertensive group, after adjusting for age and gender (p &lt; 0.001). Conclusion: Based on these results, essential hypertension is associated with a higher prevalence of hyperinsulinemia and insulin resistance in the non-diabetic community in Iran

Effect of exercise training before mating on mRNA expression of breast cancer-related genes in offspring in rats | [Effet de l'entraînement physique avant l'accouplement sur l'expression de l'ARNm de gènes liés au cancer du sein chez la progéniture du rat]

Purpose. — Exercise is associated with reduced risk of breast cancer, however, effect of parental exercise on risk of breast cancer in children has not been studied. Thus, the aim of the present study was evaluating the effect of aerobic training of parents before pregnancy on the expression of some of the main genes in breast cancer in breast tissue of their offspring. Method. — Eighteen female and 6 male Sprague Dawley rats were randomly divided into two exercise training and control group. After training each male mated with 2 females. Parental aerobic training with moderate intensity was performed running on treadmill for 4 weeks, 5 sessions per week. Finally Pairs 4, 5, and 6 of adult breast tissues was performed to evaluate the expression of BRCA1, TP53, ER-, IGF-1 and IGF-1R