Top production at the Tevatron/LHC and nonstandard, strongly interacting spin one particles

In this note, we consider possible constraints from $t \bar t$ production on the gauge bosons of theories with an extended strong interaction sector such as axigluons or flavour universal colorons. Such constraints are found to be competitive with those obtained from the dijet data. The current $t \bar t$ data from the Tevatron rule out axigluon masses ($m_A$) up to 900 GeV and 850 GeV at 2 $\sigma$ and 4 $\sigma$ levels respectively. For the case of flavour universal colorons the data rule out a mass ($m_C$) below 800 GeV (780 GeV) at the $2 (4) \sigma$ level and also the mass range between 900 GeV to 2.1 TeV at 2 $\sigma$ level, for $\cot \xi = 1$, where $\xi$ is the mixing angle. For $\cot \xi =2$ on the other hand, the excluded range is m_C \lsim 950 (920) GeV and m_C \gsim 1.02 (1.15 \lsim m_C \lsim 1.8) TeV at $2 \sigma$ ($4 \sigma$) level. We point out that for higher axigluon/coloron masses, even for the dijet channel, the limits on the coloron mass, for $\cot \xi = 1$, may be different than those for the axigluon. We also compute the expected forward-backward asymmetry for the case of the axigluons which would allow it to be discriminated against the SM as also the colorons. We further find that at the LHC, the signal should be visible in the $t \bar t$ invariant mass spectrum for a wide range of axigluon and coloron masses that are still allowed. We point out how top polarisation may be used to further discriminate the axigluon and coloron case from the SM as well as from each other.Comment: 15 pages, uses LaTex, six figures. To appear in Physics Letters B. Reference to and discussion on the forward-backward asymmetry expected even in the SM, adde

Propagation of Tau Pathology: Integrating Insights From Postmortem and In Vivo Studies

Cellular accumulation of aggregated forms of the protein tau is a defining feature of so-called tauopathies such as Alzheimer's disease, progressive supranuclear palsy, and chronic traumatic encephalopathy. A growing body of literature suggests that conformational characteristics of tau filaments, along with regional vulnerability to tau pathology, account for the distinct histopathological morphologies, biochemical composition, and affected cell types seen across these disorders. In this review, we describe and discuss recent evidence from human postmortem and clinical biomarker studies addressing the differential vulnerability of brain areas to tau pathology, its cell-to-cell transmission, and characteristics of the different strains that tau aggregates can adopt. Cellular biosensor assays are increasingly used in human tissue to detect the earliest forms of tau pathology, before overt histopathological lesions (i.e., neurofibrillary tangles) are apparent. Animal models with localized tau expression are used to uncover the mechanisms that influence spreading of tau aggregates. Further, studies of human postmortem-derived tau filaments from different tauopathies injected in rodents have led to striking findings that recapitulate neuropathology-based staging of tau. Furthermore, the recent advent of tau positron emission tomography and novel fluid-based biomarkers render it possible to study the temporal progression of tau pathology in vivo. Ultimately, evidence from these approaches must be integrated to better understand the onset and progression of tau pathology across tauopathies. This will lead to improved methods for the detection and monitoring of disease progression and, hopefully, to the development and refinement of tau-based therapeutics

Increased strontium uptake in trabecular bone of ovariectomized calcium-deficient rats treated with strontium ranelate or strontium chloride

Based on clinical trials showing the efficacy to reduce vertebral and non-vertebral fractures, strontium ranelate (SrR) has been approved in several countries for the treatment of postmenopausal osteoporosis. Hence, it is of special clinical interest to elucidate how the Sr uptake is influenced by dietary Ca deficiency as well as by the formula of Sr administration, SrR versus strontium chloride (SrCl2). Three-month-old ovariectomized rats were treated for 90 days with doses of 25 mg kg-1 d-1 and 150 mg kg-1 d-1 of SrR or SrCl2 at low (0.1% Ca) or normal (1.19% Ca) Ca diet. Vertebral bone tissue was analysed by confocal synchrotron-radiation-induced micro X-ray fluorescence and by backscattered electron imaging. Principal component analysis and k-means clustering of the acquired elemental maps of Ca and Sr revealed that the newly formed bone exhibited the highest Sr fractions and that low Ca diet increased the Sr uptake by a factor of three to four. Furthermore, Sr uptake in bone of the SrCl2-treated animals was generally lower compared with SrR. The study clearly shows that inadequate nutritional calcium intake significantly increases uptake of Sr in serum as well as in trabecular bone matrix. This indicates that nutritional calcium intake as well as serum Ca levels are important regulators of any Sr treatment

Cosmic Ray Extremely Distributed Observatory: a global network of detectors to probe contemporary physics mysteries

In the past few years, cosmic-rays beyond the GZK cut-off ($E > 5 \times 10^{19}$ eV) have been detected by leading collaborations such as Pierre Auger Observatory. Such observations raise many questions as to how such energies can be reached and what source can possibly produce them. Although at lower energies, mechanisms such as Fermi acceleration in supernovae front shocks seem to be favored, top-down scenarios have been proposed to explain the existence of ultra-high energy cosmic-rays: the decay of super-massive long-lived particles produced in the early Universe may yield to a flux of ultra-high energy photons. Such photons might be presently generating so called super-preshowers, an extended cosmic-ray shower with a spatial distribution that can be as wide as the Earth diameter. The Cosmic Ray Extremely Distributed Observatory (CREDO) mission is to find such events by means of a network of detectors spread around the globe. CREDO's strategy is to connect existing detectors and create a worldwide network of cosmic-ray observatories. Moreover, citizen-science constitutes an important pillar of our approach. By helping our algorithms to recognize detection patterns and by using smartphones as individual cosmic-ray detectors, non-scientists can participate in scientific discoveries and help unravel some of the deepest mysteries in physics.Comment: excited QCD Conference, CREDO Collaboration, 7 pages, 3 figure