Lessons Learned from Introducing a Learning Management System to Support Face to Face and Blended Learning Courses in an MBA Programme

Although there are a number of benefits and recommendations that are common to most educational institutions that adopt a learning management system (LMS), there are also some positives and negatives peculiar to the particular institution under consideration. This study looks at the implementation of a LMS at a leading business school in the Caribbean. This school was chosen because there were some characteristics in terms of the governance structure and organization of the school that brings out some peculiarities that may be found in other business schools. In addition to identifying these peculiarities and the issues that they raise, some recommendations are made for how these can be addressed to ensure that the benefits of the LMS can be maximized. From these experiences a methodology will be posited which can be used by other educational institutions considering adopting a LMS

The great agricultural biotechnology debates: Outcomes from the workshops

Workshop report and recommendation

Towards Developing a Cost-Benefit Model for Learning Management Systems

Although Learning Management Systems (LMS) have become a common place in higher education many stakeholders invest in this technology once the expected benefits align with the strategic goals of the institution and the technology falls within a given budget. However, it is not immediately apparent how stakeholders can determine whether the level of investment associated with implementing the LMS is justified by the benefits obtained. In this paper, a case study will be used to identify the costs and benefits associated with the implementation of a web-based LMS. In the instances where these costs and benefits and indirect, measures will be proposed that can be used to quantify them. The goal is to produce information that stakeholders can use to understand the value of their investments and at the same time, practitioners can use the information to maximize the value of the investment in a LMS

Traces, CSLBS Newsletter Winter 2023

With contributions from Matthew J. Smith, Lila O’Leary Chambers, and Celia E. Naylor

Chromatin modification of Apaf-1 restricts the apoptotic pathway in mature neurons

Although apoptosis has been extensively studied in developing neurons, the dynamic changes in this pathway after neuronal maturation remain largely unexplored. We show that as neurons mature, cytochrome c– mediated apoptosis progresses from inhibitor of apoptosis protein–dependent to –independent regulation because of a complete loss of Apaf-1 expression. However, after DNA damage, mature neurons resynthesize Apaf-1 through the cell cycle–related E2F1 pathway and restore their apoptotic potential. Surprisingly, we find that E2F1 is sufficient to induce Apaf-1 expression in developing but not mature neurons. Rather, Apaf-1 up-regulation in mature neurons requires both chromatin derepression and E2F1 transcriptional activity. This differential capacity of E2F1 to induce Apaf-1 transcription is because of the association of the Apaf-1 promoter with active chromatin in developing neurons and repressed chromatin in mature neurons. These data specifically illustrate how the apoptotic pathway in mature neurons becomes increasingly restricted by a novel mechanism involving the regulation of chromatin structure

A compilation, tabulation and analysis of spelling errors made by pupils in grades four, five, and six in free writing of sentences using given stimuli words

Thesis (M.A.)--Boston Universit

Competition for Antigen at the Level of the APC Is a Major Determinant of Immunodominance during Memory Inflation in Murine Cytomegalovirus Infection

The unique ability of CMV to drive the expansion of virus-specific T cell populations during the course of a lifelong, persistent infection has generated interest in the virus as a potential vaccine strategy. When designing CMV-based vaccine vectors to direct immune responses against HIV or tumor Ags, it becomes important to understand how and why certain CMV-specific populations are chosen to inflate over time. To investigate this, we designed recombinant murine CMVs (MCMVs) encoding a SIINFEKL-enhanced GFP fusion protein under the control of endogenous immediate early promoters. When mice were infected with these viruses, T cells specific for the SIINFEKL epitope inflated and profoundly dominated T cells specific for nonrecombinant (i.e., MCMV-derived) Ags. Moreover, when the virus encoded SIINFEKL, T cells specific for nonrecombinant Ags displayed a phenotype indicative of less frequent exposure to Ag. The immunodominance of SIINFEKL-specific T cells could not be altered by decreasing the number of SIINFEKL-specific cells available to respond, or by increasing the number of cells specific for endogenous MCMV Ags. In contrast, coinfection with viruses expressing and lacking SIINFEKL enabled coinflation of T cells specific for both SIINFEKL and nonrecombinant Ags. Because coinfection allows presentation of SIINFEKL and MCMV-derived Ags by different cells within the same animal, these data reveal that competition for, or availability of, Ag at the level of the APC determines the composition of the inflationary response to MCMV. SIINFEKL\u27s strong affinity for H-2K(b), as well as its early and abundant expression, may provide this epitope\u27s competitive advantage

Graph-Controlled Insertion-Deletion Systems

In this article, we consider the operations of insertion and deletion working in a graph-controlled manner. We show that like in the case of context-free productions, the computational power is strictly increased when using a control graph: computational completeness can be obtained by systems with insertion or deletion rules involving at most two symbols in a contextual or in a context-free manner and with the control graph having only four nodes.Comment: In Proceedings DCFS 2010, arXiv:1008.127