A newly derived small synthetic compound alleviated ventricular fibrillation in a pig model with chronic myocardial infarction as revealed by optical mapping

published_or_final_versionThe 16th Medical Resarch Conference (MRC), The University of Hong Kong, Hong Kong, China, 22 January 2011. In Hong Kong Medical Journal, 2011, v. 17, suppl. 1, p. 13-14, abstract no. 1

Impact of Antithrombotic Therapy in Atrial Fibrillation on the Presentation of Coronary Artery Disease

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Improvement of surface ECG recording in adult zebrafish reveals that the value of this model exceeds our expectation

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Quinidine for Brugada syndrome: Panacea or poison?

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Recent Advances in Animal and Human Pluripotent Stem Cell Modeling of Cardiac Laminopathy

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One-year clinical outcomes of patients implanted with a Resolute Onyx™ zotarolimus-eluting stent

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PR interval prolongation in coronary patients or risk equivalent: excess risk of ischemic stroke and vascular pathophysiological insights

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Modeling Treatment Response for Lamin A/C Related Dilated Cardiomyopathy in Human Induced Pluripotent Stem Cells.

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Use of the SAMe-TT2R2 Score to Predict Good Anticoagulation Control with Warfarin in Chinese Patients with Atrial Fibrillation: Relationship to Ischemic Stroke Incidence

BACKGROUND: The efficacy and safety of warfarin therapy for stroke prevention in atrial fibrillation (AF) depends on the time in therapeutic range (TTR). We aimed to assess the predictive ability of SAMe-TT2R2 score in Chinese AF patients on warfarin, whose TTR is notoriously poor. METHODS AND RESULTS: This is a single-centre retrospective study. Patients with non-valvular AF on warfarin diagnosed between 1997 and 2011 were stratified according to SAMe-TT2R2 score, and TTR was calculated using Rosendaal method. The predictive power of SAMe-TT2R2 scores for good TTR i.e. >70% was assessed. We included 1,428 Chinese patients (mean age 76.2+/-8.7 years, 47.5% male) with non-valvular AF on warfarin. The mean and median TTR were 38.2+/-24.4% and 38.8% (interquartile range: 17.9% and 56.2%) respectively. TTR decreased progressively with increasing SAMe-TT2R2 score (p = 0.016). When the cut-off value of SAMe-TT2R2 score was set to 2, the sensitivity and specificity to predict TTR/=70% had a lower annual risk of ischemic stroke of 3.67%/year compared with than those with TTR/=4 (6.41%/year)(p2 having high sensitivity and negative predictive values for poor TTR. Ischemic stroke risk increased progressively with increasing SAMe-TT2R2 score, consistent with poorer TTRs at high SAMe-TT2R2 scores.published_or_final_versio

Attenuation of Hind-limb Ischemia in Mice with Endothelial-like Cells Derived from Different Sources of Human Stem Cells

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