Adjustments to amputation and artificial limb, and quality of life in lower limb amputees

Amputatie van ledematen heeft een grote impact op het individu, niet alleen bij de vervalsing van het lichaamsbeeld, maar ook van invloed op hun sociale en psychologische functioneren. Prothese is de enige manier waarop deze mensen kunnen onafhankelijk zijn, deel te nemen aan de samenleving, en hervatten hun werk. Er zijn verschillende factoren, die het gebruik van prothese door geamputeerden kan ook van invloed zijn en op hun beurt van invloed op hun kwaliteit van leven (QoL). De onderzoeksvragen die zullen worden bestudeerd zijn: I. Wat is er bekend in de wetenschappelijke literatuur over de kwaliteit van leven van mensen met een beenamputatie? 2. Is de vertaald en aangepast gezondheidsgerelateerde QoL instrument in het Hindi taal betrouwbare en valide om te worden gebruikt in India? 3. Welke sociaal-demografische, medische en amputatie-gerelateerde factoren zijn gerelateerd aan de aanpassing van amputatie en prothese? 4. Wat zijn de rollen van de aanpassing aan amputatie en prothese bij het bepalen van de kwaliteit van leven in de onderste ledematen amputatie

Hydroxymethylation of DNA

DNA methylation, an epigenetic mechanism is claimed to play essential roles in development, aging and disease over the past few decades. Cytosines (C) were known to exist in two functional states: unmethylated or methylated (5mC) in the mammalian genome for a very long time. However, the mechanisms controlling 5mC dynamics remain undefined. Recent studies of genomic DNA on human and mouse brain, neurons and from mouse embryonic stem cells have shown that 2-oxoglutarate and Fe(II)-dependent oxygenases of the ten-eleven translocation (Tet) proteins can catalyze the oxidation of 5mC at cpG dinucleotides to form 5-hydroxymethylcytosine (5-hmC). The exhilarating discovery of these novel 5-hmC has begun to focus on the dynamic nature of 5mC. The prevailing evidence has shown that Tet family proteins and 5-hmC are involved in the normal development as well as in many diseases. This review presents an overview of the role of Tet family proteins and 5-hmC. It also discusses their role as an epigenetic marker and the techniques used for their analysis

Bracing for a resurgence of Covid in a 3rd Wave: Uttarakhand Saga

Evidently, the resurgence of COVID in a 2nd wave happened due largely to ‘Risk Compensation’ by the community, exacerbated by extreme risk behavior of the community. ‘Risk compensation’ or ‘Peltzman effect’, where there is an attitudinal shift underestimating the risk and subsequent complacency in observing due measures is almost an axiomatic phenomenon and this was being predicted in case of COVID too(1). However the scale, extent and intensity of the re-surgence (second wave) which was exponential & ‘asymptotic‘ was unwarranted, also unprecedented. That this re-surgence was a predictable phenomenon and needed pro-active & pragmatic strategizing/ decision making (which would affect community behavior vis a vis religious congregation and or other public events abetting gathering of crowd etc) was not unknown

A Survey on Challenges to the Media Cloud

Content of a media over Internet consumes significant amount of energy. Numerous application media applications, services and devices have introduced and clients are consuming more and more media. Media processing requires great capacity and capability.[1] Cloud computing has proven a best technology for providing various services, great computing power, massive storage and bandwidth with modest cost. Integration of Media and Cloud can become very beneficial for both and hence becomes media cloud. In this paper we have discussed several challenges of media cloud. Those include Integration, Storage, Processing and Delivery

Apoptosis: molecular mechanisms and pathogenicity

Apoptosis triggered by exogenous and endogenous stimuli such as ultraviolet radiation, oxidative stress, and genotoxic chemicals is a crucial phenomenon within biological systems. DNA damage activates and stabilizes p53 in nucleus and cytoplasm and regulates other proteins that stimulate intrinsic and extrinsic apoptotic pathways. Apoptosis is morphologically distinct from that of necrosis and both the phenomena depend on the types, developmental stages, physiological environment of tissues and the nature of death signal. Malfunctioning of apoptotic pathway may cause human diseases like cancer, neurodegenerative and autoimmune disorders. Recently, potent apoptosis-inducing compounds associated with human health have been recorded that prevent tumor promotion, progression, and the occurrence of cellular inflammatory responses. Certain photosensitizing drugs are being employed in photodynamic therapy to induce apoptosis for the treatment of cancer and non-cancerous cells. This review emphasizes the molecular mechanisms of apoptosis, associated diseases and certain therapeutic agents implicated in the elimination of malignant cells