The Cryogenic AntiCoincidence detector for ATHENA X-IFU: a scientific assessment of the observational capabilities in the hard X-ray band

ATHENA is a large X-ray observatory, planned to be launched by ESA in 2028 towards an L2 orbit. One of the two instruments of the payload is the X-IFU: a cryogenic spectrometer based on a large array of TES microcalorimeters, able to perform integral field spectrography in the 0.2-12 keV band (2.5 eV FWHM at 6 keV). The X-IFU sensitivity is highly degraded by the particle background expected in the L2 orbit, which is induced by primary protons of both galactic and solar origin, and mostly by secondary electrons. To reduce the particle background level and enable the mission science goals, the instrument incorporates a Cryogenic AntiCoincidence detector (CryoAC). It is a 4 pixel TES based detector, placed <1 mm below the main array. In this paper we report a scientific assessment of the CryoAC observational capabilities in the hard X-ray band (E>10 keV). The aim of the study has been to understand if the present detector design can be improved in order to enlarge the X-IFU scientific capability on an energy band wider than the TES array. This is beyond the CryoAC baseline, being this instrument aimed to operate as anticoincidence particle detector and not conceived to perform X-ray observations.Comment: Accepted for publication on Experimental Astronom

Impact of chronic exposure to bevacizumab on EpCAM-based detection of circulating tumor cells

BACKGROUND: Circulating tumor cells (CTCs) are often undetected through the immunomagnetic epithelial cell adhesion molecule (EpCAM)-based CellSearch(®) System in breast and colorectal cancer (CRC) patients treated with bevacizumab (BEV), where low CTC numbers have been reported even in patients with evidence of progression of disease. To date, the reasons for this discrepancy have not been clarified. This study was carried out to investigate the molecular and phenotypic changes in CRC cells after chronic exposure to BEV in vitro. METHODS: The human CRC cell line WiDr was exposed to a clinically relevant dose of BEV for 3 months in vitro. The expression of epithelial and mesenchymal markers and EpCAM isoforms was determined by western blotting and immunofluorescence. To evaluate the impact of EpCAM variant isoforms expression on CTC enumeration by CellSearch(®), untreated and treated colon cancer cells were spiked into 7.5 mL of blood from a healthy donor and enumerated by CellSearch(®). RESULTS: Chronic exposure of CRC cell line to BEV induced decreased expression of EpCAM 40 kDa isoform and increased expression EpCAM 42 kDa isoform, together with a decreased expression of cytokeratins (CK), while no evidence of epithelial to mesenchymal transition (EMT) in treated cells was observed. The recovery rate of cells through CellSearch(®) was gradually reduced in course of treatment with BEV, being 84%, 70% and 40% at 1, 2 and 3 months, respectively. CONCLUSIONS: We hypothesize that BEV may prevent CellSearch(®) from capturing CTCs through altering EpCAM isoforms

Geant4 simulations of soft proton scattering in X-ray optics. A tentative validation using laboratory measurements

Low energy protons (< 300 keV) can enter the field of view of X-ray space telescopes, scatter at small incident angles, and deposit energy on the detector, causing intense background flares at the focal plane or in the most extreme cases, damaging the X-ray detector. A correct modelization of the physics process responsible for the grazing angle scattering processes is mandatory to evaluate the impact of such events on the performance of future X-ray telescopes as the ESA ATHENA mission. For the first time the Remizovich model, in the approximation of no energy losses, is implemented top of the Geant4 release 10.2. Both the new scattering physics and the built-in Coulomb scattering are used to reproduce the latest experimental results on grazing angle proton scattering. At 250 keV multiple scattering delivers large proton angles and it is not consistent with the observation. Among the tested models, the single scattering seems to better reproduce the scattering efficiency at the three energies but energy loss obtained at small scattering angles is significantly lower than the experimental values. In general, the energy losses obtained in the experiment are higher than what obtained by the simulation. The experimental data are not completely representative of the soft proton scattering experienced by current X-ray telescopes because of the lack of measurements at low energies (< 200 keV) and small reflection angles, so we are not able to address any of the tested models as the one that can certainly reproduce the scattering behavior of low energy protons expected for the ATHENA mission. We can, however, discard multiple scattering as the model able to reproduce soft proton funneling, and affirm that Coulomb single scattering can represent, until further measurements, the best approximation of the proton scattered angular distribution at the exit of X-ray optics.Comment: submitted to Experimental Astronom

Updates on the background estimates for the X-IFU instrument onboard of the ATHENA mission

ATHENA, with a launch foreseen in 2028 towards the L2 orbit, addresses the science theme "The Hot and Energetic Universe", coupling a high-performance X-ray Telescope with two complementary focal-plane instruments. One of these, the X-ray Integral Field Unit (X-IFU) is a TES based kilo-pixel array providing spatially resolved high-resolution spectroscopy (2.5 eV at 6 keV) over a 5 arcmin FoV. The background for this kind of detectors accounts for several components: the diffuse Cosmic X-ray Background, the low energy particles (<~100 keV) focalized by the mirrors and reaching the detector from inside the field of view, and the high energy particles (>~100 MeV) crossing the spacecraft and reaching the focal plane from every direction. Each one of these components is under study to reduce their impact on the instrumental performances. This task is particularly challenging, given the lack of data on the background of X-ray detectors in L2, the uncertainties on the particle environment to be expected in such orbit, and the reliability of the models used in the Monte Carlo background computations. As a consequence, the activities addressed by the group range from the reanalysis of the data of previous missions like XMM-Newton, to the characterization of the L2 environment by data analysis of the particle monitors onboard of satellites present in the Earth magnetotail, to the characterization of solar events and their occurrence, and to the validation of the physical models involved in the Monte Carlo simulations. All these activities will allow to develop a set of reliable simulations to predict, analyze and find effective solutions to reduce the particle background experienced by the X-IFU, ultimately satisfying the scientific requirement that enables the science of ATHENA. While the activities are still ongoing, we present here some preliminary results already obtained by the group

First assessment of non-X-ray background in Line Emission Mapper (LEM) focal plane detector.

The LEM (Line Emission Mapper) mission proposal envisions a cryogenic microcalorimeter array optimized for the 0.2–2 keV energy band, based on the X-IFU heritage. The array will consist of 13,806 absorber pixels with a 290 µm pitch, in hexagonal arrangement, that for a 4 m focal length will cover a solid angle equal to 29.4 square degrees. The orbit for LEM is currently under study with the Sun-Earth Lagrange points L1 and L2 possible candidates. For what concerns the non X-Ray background (NXB), the premises are very similar to the X-IFU case. The background estimates are performed using Monte Carlo simulations with the Geant4 software [RD1] and, as a consequence, minor modifications to the X-IFU simulations can give precious insights on the NXB level to be expected for the instrument. Furthermore, it is possible to test the effect of changes to the instrument mass model (sensitivity analysis) and identify the configuration that optimizes the detector performances

NuSTAR and XMM-Newton observations of 1E1743.1-2843: indications of a neutron star LMXB nature of the compact object

We report on the results of NuSTAR and XMM-Newton observations of the persistent X-ray source 1E1743.1-2843, located in the Galactic Center region. The source was observed between 2012 September and October by NuSTAR and XMM-Newton, providing almost simultaneous observations in the hard and soft X-ray bands. The high X-ray luminosity points to the presence of an accreting compact object. We analyze the possibilities of this accreting compact object being either a neutron star (NS) or a black hole, and conclude that the joint XMM-Newton and NuSTAR spectrum from 0.3 to 40 keV fits a blackbody spectrum with kT ~ 1.8 keV emitted from a hot spot or an equatorial strip on an NS surface. This spectrum is thermally Comptonized by electrons with kT_e ~ 4.6 keV. Accepting this NS hypothesis, we probe the low-mass X-ray binary (LMXB) or high-mass X-ray binary (HMXB) nature of the source. While the lack of Type-I bursts can be explained in the LMXB scenario, the absence of pulsations in the 2 mHz–49 Hz frequency range, the lack of eclipses and of an IR companion, and the lack of a K_ɑline from neutral or moderately ionized iron strongly disfavor interpreting this source as a HMXB. We therefore conclude that 1E1743.1-2843 is most likely an NS-LMXB located beyond the Galactic Center. There is weak statistical evidence for a soft X-ray excess which may indicate thermal emission from an accretion disk. However, the disk normalization remains unconstrained due to the high hydrogen column density (N_H ~ 1.6 x 10^(23)cm^(-2)

Crab: conteggi attesi dalla CryoAC

Lo scopo di questo documento e’ fornire una stima del flusso di fotoni che, non assorbiti dal TES-array, generano un segnale nel rivelatore di anticoincidenza (CryoAC) avendo quest’ultimo di fatto una soglia operativa bassa (circa un fattore 10 minore del requisito)

Results of a research regarding the variability of spring depletion curves

Springs, no recharge periods, discharge process, depletion coefficient