A importância da assistência de enfermagem na realização do pré-natal de gestantes com Diabetes Gestacional: uma revisão integrativa da literatura

Introdução: A Diabetes Gestacional (DG) é uma patologia caracterizada pelo aumento de glicose no sangue, decorrente do período gestacional, essa patologia tanto pode comprometer a saúde do bebê quanto da mãe. Uma das formas de diagnosticar a DG é realizando o exame de glicemia em jejum, que se trata de um exame simples que é solicitado pelo enfermeiro na primeira consulta do acompanhamento pré-natal. Objetivo: descrever a importância do enfermeiro no diagnóstico da Diabetes Mellitus Gestacional durante as consultas do pré-natal nas Unidades Básicas de Saúde. Metodologia: Trata-se de um estudo do tipo revisão integrativa da literatura no qual teve início e término em junho de 2022. Os descritores enfermagem, diabetes gestacional e pré-natal foram utilizados para realizar a busca por publicações em três bases de dados, Lilacs, Scielo e Medline. Resultados e Discussões: Foi possível identificar a importância do enfermeiro em todo o processo gestacional, uma vez que é o primeiro profissional a prestar assistência à gestante, solicita exames e na maioria das vezes é quem identifica patologias importantes, como a Diabetes Gestacional, além de estar presente até o período pós-parto da gestante. Considerações finais: A partir do momento em que a mulher é diagnosticada, ela já recebe as orientações do enfermeiro e é encaminhada para acompanhamento médico e, se necessário, realizar terapia medicamentosa, conforme prescrição médica

Assistência de enfermagem ao recém-nascido pré- termo em Unidades de Terapia Intensiva Neonatal: revisão integrativa da literatura

Introdução: Prematuridade Neonatal é um termo utilizado pela ciência da saúde para o nascimento do indivíduo antes do tempo considerado dentro da normalidade, ou seja, antes da 37ª semana de gestação. São classificados como: prematuros extremos, intermediários e prematuros tardios. A prematuridade neonatal é considerada um problema de saúde pública no Brasil, onde cerca de 280 mil bebês nascem, anualmente, antes de completarem 37 semanas de gestação, podendo este fato ocorrer por complicações maternas (ruptura prematura das membranas amnióticas, doenças maternas, asma, entre outras) e por indicação médica (presença de condição materna ou fetal que ocasione risco de morte para a mãe e/ou feto), necessitando de uma intervenção imediata. Objetivo: Buscar na literatura estudos que destaquem a assistência de enfermagem ao recém-nascido pré-termo em Unidades de Terapia Intensiva Neonatal. Metodologia: Trata-se de um estudo do tipo revisão integrativa da literatura no qual teve início no segundo semestre de 2021 e término no primeiro trimestre de 2022. Foram as bases de dados LILACS, SCIELO e BDENF. Resultados e Discussões: Foram encontradas 122 (cento e vinte e duas) publicações durante o período de 2017 a 2021, e destas, foram selecionadas 10 (dez) para a discussão do presente estudo. Foram evidenciados alguns riscos, tais como: hipotermia, infecção, integridade da pele prejudicada, icterícia, desequilíbrio hidroeletrolítico, amamentação interrompida, instabilidade glicêmica. Conclusão: Os cuidados prestados pela equipe de enfermagem aos recém-nascidos prematuros são diversos. Cabe destacar que, assim como outras unidades especializadas, os profissionais que atuam no setor de neonatologia atendem o público com características muito específicas, que exigem habilidades e conhecimentos específicos

Assessment Of Orofacial Dysfunctions, Salivary Cortisol Levels And Oral Health Related Quality Of Life (orhqol) In Young Adults.

To investigate the relationship of orofacial dysfunction and salivary cortisol levels with oral health quality of life (ORHQoL) in young adults. Thirty individuals of both genders (22.93±2.42 years) participated. The orofacial dysfunction was evaluated using the Nordic Orofacial Test-Screening (NOT-S) and the ORHQoL using the Oral Health Impact Profile (OHIP-49). Saliva samples were collected during three days, at waking up and 30 min after, obtaining the awakening cortisol response - ACR. The data were analysed by Mann-Whitney test, Spearman's correlation and multiple linear regression (α=0.05). The NOT-S scores and ACR (μg/dl) were dichotomized by the median (2.0 and 0.15, respectively). NOT-S and ACR showed similar values between genders (P>0.05). The individuals with NOT-S scores above the median presented values of physical pain domain significantly higher than the individuals with scores bellow or equal to the median. Significant correlations were found between the OHIP-49 domains physical pain and physical disability and NOT-S scores. In multiple linear regression, significant values were observed between NOT-S and OHIP-49 and the domains physical pain, physical disability, psychological disability, social disability and handicap, with determination coefficients ranging from 0.09 to 0.15. There was not association with the ACR. Individuals with orofacial dysfunction presented impairment in ORHQoL, but not enough to change salivary cortisol levels. Furthermore, gender did not have influence on ORHQoL in the studied sample.561521-

Assessment of orofacial dysfunctions, salivary cortisol levels and oral health related quality of life (ORHQoL) in young adults

AbstractObjectiveTo investigate the relationship of orofacial dysfunction and salivary cortisol levels with oral health quality of life (ORHQoL) in young adults.DesignThirty individuals of both genders (22.93±2.42 years) participated. The orofacial dysfunction was evaluated using the Nordic Orofacial Test-Screening (NOT-S) and the ORHQoL using the Oral Health Impact Profile (OHIP-49). Saliva samples were collected during three days, at waking up and 30min after, obtaining the awakening cortisol response – ACR. The data were analysed by Mann–Whitney test, Spearman's correlation and multiple linear regression (α=0.05). The NOT-S scores and ACR (μg/dl) were dichotomized by the median (2.0 and 0.15, respectively).ResultsNOT-S and ACR showed similar values between genders (P>0.05). The individuals with NOT-S scores above the median presented values of “physical pain” domain significantly higher than the individuals with scores bellow or equal to the median. Significant correlations were found between the OHIP-49 domains “physical pain” and “physical disability” and NOT-S scores. In multiple linear regression, significant values were observed between NOT-S and OHIP-49 and the domains physical pain, physical disability, psychological disability, social disability and handicap, with determination coefficients ranging from 0.09 to 0.15. There was not association with the ACR.ConclusionsIndividuals with orofacial dysfunction presented impairment in ORHQoL, but not enough to change salivary cortisol levels. Furthermore, gender did not have influence on ORHQoL in the studied sample

Interaction pathways of specific co-solvents with hydroxypropyl-β-cyclodextrin inclusion complexes with benznidazole in liquid and solid phase

The main purpose of the study was to assess the mechanism whereby the co-solvents triethanolamine (TEA) and 1-methyl-2-pyrrolidone (NMP) interacted with hydroxypropyl-beta-cyclodextrin (HP-β-CD) in ternary associations for improving the solubility and dissolution rate of the insoluble ingredient benznidazole (BNZ). In liquid phase, the solubility diagrams and Job's plot results were further explored by in silico molecular modeling and experimental 1H NMR spectroscopy studies. The structure of the inclusion complexes in the binary and ternary association were established. The competition of NMP with the drug for the HP-β-CD cavity was evidenced, while TEA stabilized the drug-CD interactions, forming ternary complexes. FTIR analysis confirmed distinct intermolecular interactions among the compounds in the different solid dispersions prepared by physical mixture (PM) and spray drying (SD). The co-solvents improved the drug dissolution performance from PM ternary associations due to their enhanced wettability of particles changing the drug-CD interaction. In addition to the SD samples exhibiting spherical particles, the co-solvents increased the crystallinity of drug in the particles and the ternary associations did not reproduce the drug dissolution rate identified in the PM samples. The experimental results proved the importance of the co-solvents to improve the drug dissolution performance from ternary complexes and established the mechanism whereby these substances worked together with the CD in a new and promising raw material. Due to the high temperature, the spray drying was not a suitable method for preparing the specific ternary complexes.Fil: de Melo, Polyanne N.. Universidade Federal do Rio Grande do Norte; BrasilFil: Barbosa, Euzébio G.. Universidade Federal do Rio Grande do Norte; BrasilFil: Garnero, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: de Caland, Lilia B.. Universidade Federal do Rio Grande do Norte; BrasilFil: Fernandes Pedrosa, Matheus F.. Universidade Federal do Rio Grande do Norte; BrasilFil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: da Silva Júnior, Arnóbio Antônio. Universidade Federal do Rio Grande do Norte; Brasi

Host–guest interactions between benznidazole and beta-cyclodextrin in multicomponent complex systems involving hydrophilic polymers and triethanolamine in aqueous solution

Association of hydrophilic compounds with cyclodextrins to increase drug solubility has been extensively studied in aqueous solution. However, the mechanism of interaction among these components remains unclear. In this study, the mechanism of interaction of seven different hydrophilic polymers (HPs) and triethanolamine (TEA) in aqueous solution with beta-cyclodextrin (β-CD) to modify the aqueous solubility of benznidazole (BNZ) was well investigated using solubility diagrams, thermodynamic experiments, molecular modeling and NMR studies. Solubility diagrams in different pH values confirmed linear soluble BNZ-β-CD inclusion complexes, with 1:1 stoichiometry (AL type). A synergistic effect in the association of TEA with BCD did not occur, due to competition between TEA and BNZ β-CD cavity, which led to obtain inclusion complexes with limited solubility (B type). The increment of BNZ solubility occurred only at higher TEA concentrations by cosolvency mechanism, which was evidenced by solubility diagrams, molecular modeling and NMR studies. The association of different hydrophilic polymers with β-CD contributes thermodynamically to stabilize the formed complexes, in which POL 407 and PVA increased considerably the observed K1:1 value. An enthalpic contribution of hydrophilic polymers led to enhance the spontaneity of BNZ-β-CD interaction and a slight increasing in entropy change (ΔS) did possible to stabilize the interaction between BNZ and β-CD.Fil: Melo, Polyanne Nunes de. Universidade Federal do Rio Grande do Norte; BrasilFil: Barbosa, Euzébio Guimarães. Universidade Federal do Rio Grande do Norte; BrasilFil: Caland, Lília Basílio de. Universidade Federal do Rio Grande do Norte; BrasilFil: Carpegianni, Hugo. Universidade Federal do Rio Grande do Norte; BrasilFil: Garnero, Claudia. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Longhi, Marcela Raquel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fernandes Pedrosa, Matheus de Freitas. Universidade Federal do Rio Grande do Norte; BrasilFil: Silva Júnior, Arnóbio Antônio da. Universidade Federal do Rio Grande do Norte; Brasi

Triethanolamine Stabilization of Methotrexate-β-Cyclodextrin Interactions in Ternary Complexes

The interaction of methotrexate (MTX) with beta-cyclodextrin (β-CD) in the presence of triethanolamine (TEA) was investigated with the aim to elucidate the mechanism whereby self-assembly cyclodextrin systems work in association with this third component. Solubility diagram studies showed synergic increment of the MTX solubility to be about thirty-fold. Experiments using 2D ROESY and molecular modeling studies revealed the inclusion of aromatic ring III of the drug into β-CD cavity, in which TEA contributes by intensifying MTX interaction with β-CD and stabilizes MTX:β-CD:TEA ternary complex by electrostatic interaction. The maintenance of these interactions in solid phase was also studied in ternary MTX:β-CD:TEA and comparisons were made with freeze dried binary MTX:β-CD and physical mixtures. FTIR studies evidenced that MTX–β-CD interaction remained in solid ternary complexes, which was also supported by thermal (differential scanning calorimetry (DSC), thermogravimetric analysis (TG)/first derivative of TG analysis (DTG) and C,N,H elementary analysis) and structural (X-ray diffraction analysis, (XRD)) studies, mainly regarding the increment of drug stability. The efficient in vitro drug dissolution studies successfully demonstrated the contribution of ternary complexes, which highlights the importance of this possible new raw material for further applications in drug delivery systemsFil: Barbosa, Jahamunna A.. Universidade Federal do Rio Grande do Norte; BrasilFil: Zoppi, Ariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Quevedo, Mario Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: de Melo, Polyanne. Universidade Federal do Rio Grande do Norte; BrasilFil: de Medeiros, Arthur S. A. Universidade Federal do Rio Grande do Norte; BrasilFil: Streck, Leticia. Universidade Federal do Rio Grande do Norte; BrasilFil: de Oliveira, Alice R.. Universidade Federal do Rio Grande do Norte; BrasilFil: Fernandes Pedrosa, Matheus F.. Universidade Federal do Rio Grande do Norte; BrasilFil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: da Silva Junior, Arnobio A.. Universidade Federal do Rio Grande do Norte; Brasi