Microfundamentos de falencia de bancos atacadistas : a experiencia brasileira nos anos 90

Orientador : Otaviano Canuto dos Santos FilhoDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de EconomiaMestradoMestre em Ciências Econômica

Impacto do Sistema Cooperativo de Crédito na Eficiência do Sistema Financeiro Nacional

The aim of this paper is to analyze the impact of the Brazilian Cooperative Credit System (CCS) in the macroeconomic efficiency of the National Financial System (NFS), meant here as the capacity in supplying cheap financial services in a uniform way. Two aspects were evaluated: the participation of the CCS in the credit supply and the capillarity of the CCS. The paper concludes that the CCS contributes to the NFS efficiency in some aspects (e.g., greater share in poor-targeted credit), but not in others (e.g., greater absence in less developed regions).

Otimização da imunofluorescência direta para diagnóstico de raiva

O diagnóstico laboratorial da raiva utiliza uma metodologia padronizada, baseada essencialmente no método de imunofluorescência direta, ou “direct fluorescent antibody test” (DFAT). No presente estudo foram reavaliadas algumas variáveis do DFAT, incluindo a duração do tempo de fixação das lâminas com impressões de tecido nervoso, duração das incubações de pré-adsorção do conjugado com as suspensões de tecido nervoso de camundongos infectados (IMB) ou não infectados (NMB) e a duração do período de incubação destas misturas sobre as lâminas com as impressões fixadas. A combinação que proporcionou maior eficácia à DFAT foi obtida com a fixação das lâminas com impressões de tecido nervoso em acetona a -20 oC por 30 minutos, pré-adsorção do conjugado com suspensões de NMB e IMB por 60 minutos a 37oC e subseqüente incubação dessas misturas sobre as impressões por 2 horas a 37oC. Estas alterações permitiram a obtenção de uma fluorescência de intensidade sensivelmente maior que a obtida com a metodologia padrão recomendada, aliada a uma completa inibição da fluorescência sobre os controles

Antifungal activity against Cryptococcus neoformans strains and genotoxicity assessment in human leukocyte cells of Euphorbia tirucalli L.

In the last times, focus on plant research has increased all over the world. Euphorbia tirucalli L., a plant known popularly as Aveloz, and originally used in Africa, has been drawing attention for its use in the United States and Latin America, both for use as an ornamental plant and as a medicinal plant. E. tirucalli L. is a member of the family Euphorbiaceae and contains many diterpenoids and triterpenoids, in particular phorbol esters, apparently the main constituent of this plant, which are assumed to be responsible for their activities in vivo and in vitro. The in vitro antifungal activities of Euphorbia tirucalli (L.) against opportunistic yeasts were studied using microbroth dilution assay. The results showed that aqueous extract and latex preparation were effective against ten clinical strains of Cryptococcus neoformans in vitro (Latex and extract MIC range of 3.2 - > 411 g/mL). Aiming the safe use in humans, the genotoxic effects of E. tirucalli were evaluated in human leukocytes cells. Our data show that both aqueous extract and latex preparation have no genotoxic effect in human leukocytes cells in vitro. Although the results cannot be extrapolated by itself for use in vivo, they suggest a good perspective for a therapeutic application in future. In conclusion, our results show that the aqueous extract and latex preparation from E. tirucalli L. are antifungal agents effectives against several strains of C. neoformans and do not provoke DNA damage in human leukocyte cells, considering the concentrations tested

Antifungal activity against Cryptococcus neoformans strains and genotoxicity assessment in human leukocyte cells of Euphorbia tirucalli L.

In the last times, focus on plant research has increased all over the world. Euphorbia tirucalli L., a plant known popularly as Aveloz, and originally used in Africa, has been drawing attention for its use in the United States and Latin America, both for use as an ornamental plant and as a medicinal plant. E. tirucalli L. is a member of the family Euphorbiaceae and contains many diterpenoids and triterpenoids, in particular phorbol esters, apparently the main constituent of this plant, which are assumed to be responsible for their activities in vivo and in vitro. The in vitro antifungal activities of Euphorbia tirucalli (L.) against opportunistic yeasts were studied using microbroth dilution assay. The results showed that aqueous extract and latex preparation were effective against ten clinical strains of Cryptococcus neoformans in vitro (Latex and extract MIC range of 3.2 - > 411 µg/mL). Aiming the safe use in humans, the genotoxic effects of E. tirucalli were evaluated in human leukocytes cells. Our data show that both aqueous extract and latex preparation have no genotoxic effect in human leukocytes cells in vitro. Although the results cannot be extrapolated by itself for use in vivo, they suggest a good perspective for a therapeutic application in future. In conclusion, our results show that the aqueous extract and latex preparation from E. tirucalli L. are antifungal agents effectives against several strains of C. neoformans and do not provoke DNA damage in human leukocyte cells, considering the concentrations tested

Genome-wide Copy Number Variation (cnv) Detection In Nelore Cattle Reveals Highly Frequent Variants In Genome Regions Harboring Qtls Affecting Production Traits

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Copy number variations (CNVs) have been shown to account for substantial portions of observed genomic variation and have been associated with qualitative and quantitative traits and the onset of disease in a number of species. Information from high-resolution studies to detect, characterize and estimate population-specific variant frequencies will facilitate the incorporation of CNVs in genomic studies to identify genes affecting traits of importance. Results: Genome-wide CNVs were detected in high-density single nucleotide polymorphism (SNP) genotyping data from 1,717 Nelore (Bos indicus) cattle, and in NGS data from eight key ancestral bulls. A total of 68,007 and 12,786 distinct CNVs were observed, respectively. Cross-comparisons of results obtained for the eight resequenced animals revealed that 92 % of the CNVs were observed in both datasets, while 62 % of all detected CNVs were observed to overlap with previously validated cattle copy number variant regions (CNVRs). Observed CNVs were used for obtaining breed-specific CNV frequencies and identification of CNVRs, which were subsequently used for gene annotation. A total of 688 of the detected CNVRs were observed to overlap with 286 non-redundant QTLs associated with important production traits in cattle. All of 34 CNVs previously reported to be associated with milk production traits in Holsteins were also observed in Nelore cattle. Comparisons of estimated frequencies of these CNVs in the two breeds revealed 14, 13, 6 and 14 regions in high (> 20 %), low ( HOL, NEL < HOL) frequencies, respectively. Conclusions: Obtained results significantly enriched the bovine CNV map and enabled the identification of variants that are potentially associated with traits under selection in Nelore cattle, particularly in genome regions harboring QTLs affecting production traits.17Embrapa- Brazilian Agricultural Research Corporation [02.10.06.009.00, 01.11.07.002.06.00]Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [578592/2008-8]Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [2012/05002-9]Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP

33.尿道憩室結石の1例(第610回千葉医学会例会・昭和54年度産科婦人科分科会)

Descriptive statistics of CNVRs per individual bovine chromosome. (XLSX 5510 kb

Desenvolvimento de um aplicativo educacional para o auxílio na alfabetização infantil

This article refers to the development of an application that will help children in the literacy process in the school and family environment. Mobile learning through the child can learn the alphabet and associate images, text and audio without the limitation of the physical space of a learning environment. Thus facilitating the learning process