catena-Poly[[dinitratocopper(II)]-μ-4,4′′-bis­(1H-benzimidazol-1-yl)-1,1′:4′,1′′-terphen­yl]

In the title one-dimensional coordination polymer, [Cu(NO3)2(C32H22N4)]n, the Cu2+ ion (site symmetry 2) is coordinated by two nitrate O atoms and two N atoms from two 4,4′-bis­(benzoimidazol-1-yl)terphenyl (L) ligands in a distorted cis-CuN2O2 square-planar coordination geometry. An alternative description of the metal coordination geometry, if long Cu—O contacts to the bonded nitrate anions are considered, is an extremely distorted cis-CuN2O4 octa­hedron. The complete L ligand is generated by crystallographic twofold symmetry and connects the metal ions into infinite chains propagating in [10]. The dihedral angle between the benzimidazole ring system and the adjacent benzene (B) ring is 51.12 (11)° and the dihedral angle between the B ring and the central ring is 19.45 (13)°

Proteomics profiling asthma induced-lysine acetylation

Asthma is a chronic inflammatory disease that has been extensively studied for many years. However, finding a complete cure remains a significant challenge. Protein acetylation, especially histone acetylation, plays a significant role in the anti-asthma process. Histone deacetylation inhibitors (HDACi) have been shown to have a curative effect on asthma in clinical practice. An asthmatic mouse model was created by ovalbumin induction. Proteome and acetylproteome analysis were performed on lung tissues. HDACi were tested in the asthmatic mice. A total of 5346 proteins and 581 acetylation sites were identified, among which 154 proteins and 68 acetylation peptides were significantly altered by asthma. Many activated and deactivated processes, pathways, and protein groups were identified through bioinformatics analysis. Sequence motif preference analysis gave rise to a novel Kac-related core histone region, -KAXXK-, which was postulated as a key regulatory unit of histone acetylation. Asthma involves a variety of proteome dynamics and is controlled by protein lysine acetylation through the core motif -KAXXK-. These findings provide novel avenues to target and treat asthma

Uplift, Climate and Biotic Changes at the Eocene-Oligocene Transition in Southeast Tibet

The uplift history of southeastern Tibet is crucial to understanding processes driving the tectonic evolution of the Tibetan Plateau and surrounding areas. Underpinning existing palaeoaltimetric studies has been regional mapping based in large part on biostratigraphy that assumes a Neogene modernisation of the highly diverse, but threatened, Asian biota. Here, with new radiometric dating and newly-collected plant fossil archives, we quantify the surface height of part of Tibet’s southeastern margin of Tibet in the latest Eocene (~34 Ma) to be ~3 km and rising, possibly attaining its present elevation (3.9 km) in the early Oligocene. We also find that the Eocene-Oligocene transition in southeastern Tibet witnessed leaf size diminution and a floral composition change from sub-tropical/warm temperate to cool temperate, likely reflective of both uplift and secular climate change, and that by the latest Eocene floral modernization on Tibet had already taken place implying modernization was deeply-rooted in the Paleogene