Identifying Relationships Among Factors in IS Implementation

Information systems (IS) researchers find a large number of factors are related to the effectiveness of IS implementations; however, many researchers also lament the lack of theoretical relationships among the factors. In addition, recent studies of IS implementation produced conflicting results regarding the relative importance and manageability of IS implementation factors. To address these issues, we encourage researchers to think out-of-the-box as we propose a new way of viewing the traditional IS implementation factors. The nature of the relationships among the factors is analogous to Maslow\u27s generally accepted theories of individual motivation in which certain factors are necessary but not sufficient conditions for given levels of achievement

Capturing the Technological Dimensions of IT Infrastructure Change: A Model and Empirical Evidence

Information systems (IS) researchers have developed a substantial base of theoretical and empirical research for investigating phenomena associated with information technology (IT) infrastructure and IS implementation. The majority of prior studies have focused on perceptions of IS use, usefulness, support, and similar organizational and human aspects of implementation; however, recent empirical results suggest the importance of technical issues in IS implementation. As a first step toward providing more empirical research on the impact of technological issues in IS implementation, this paper reports on the development and test of a model that captures the dimensions of technological changes in IT infrastructure. Using a survey of 302 individuals who recently participated in a software upgrade, evidence is provided on the content validity, construct validity, and reliability of an instrument measuring four dimensions of perceived technological change in IS implementation: functionality, user interface, technical quality, and external compatibility. In addition, a sample application of the new model is provided which shows that technological changes in IT infrastructure affect user acceptance of information technology

Factors Affecting the Planning and Implementation of Emerging Telecommunications Technologies

This paper outlines an ongoing empirical research project to identify a set of factors affecting the proliferation of emerging telecommunications technologies in organizations. Organizations (educational institutions, businesses, etc.) need to understand telecommunications technology from both planning and implementation perspectives to achieve quality high performance networking in the future. The research will consist of four stages: formulating a conceptual framework, gathering data from organizations using computer networks, analyzing the data to determine trends and opportunities in telecommunications deployment, and determining an optimal strategy for organizational migration to an emerging telecommunications technology

DEACON: An Integrated Approach to the Analysis and Design of Enterprise Architecture-Based Computer Networks

The most common approach to network development in the modern organization remains an undocumented, ad hoc method of deploying available technology rapidly to fit within a given cost structure. Current methods largely ignore the importance of integrating the networking strategy of a firm with the overall information systems architecture of the enterprise. To address this problem, a new approach to network analysis and design is presented. The new method integrates existing principles of information systems analysis and design with the unique requirements imposed by distributed systems. The integrated approach seeks to provide the organization with a set of guidelines for allocating resources to a computer network based upon the business goals of a firm. Specifically, the method calls for (1) defining the business problem, (2) modeling business requirements, (3) modeling location requirements, (4) developing a network architecture, (5) simulating network operation, and (6) implementing the network. The method is illustrated and compared to other network development methods. DEACON is found to be an advantageous approach

Characteristics of System Requirements for Electronic Commerce

This paper outlines some critical characteristics of requirements for developing a system designed to support electronic commerce. The characteristics are based not only on traditional user and organizational needs and goals, but also on specific requirement issues that arise in developing network systems and applications for electronic commerce. We then illustrate how an commercial electronic commerce system satisfies the proposed characteristics. A longer version of the paper is available

Response of Degarelix treatment in human prostate cancer monitored by HR-MAS 1H NMR spectroscopy.

INTRODUCTION: The androgen receptor (AR) is the master regulator of prostate cancer cell metabolism. Degarelix is a novel gonadotrophin-releasing hormone blocker, used to decrease serum androgen levels in order to treat advanced human prostate cancer. Little is known of the rapid metabolic response of the human prostate cancer tissue samples to the decreased androgen levels. OBJECTIVES: To investigate the metabolic responses in benign and cancerous tissue samples from patients after treatment with Degarelix by using HRMAS 1H NMR spectroscopy. METHODS: Using non-destructive HR-MAS 1H NMR spectroscopy we analysed the metabolic changes induced by decreased AR signalling in human prostate cancer tissue samples. Absolute concentrations of the metabolites alanine, lactate, glutamine, glutamate, citrate, choline compounds [t-choline = choline + phosphocholine (PC) + glycerophosphocholine (GPC)], creatine compounds [t-creatine = creatine (Cr) + phosphocreatine (PCr)], taurine, myo-inositol and polyamines were measured in benign prostate tissue samples (n = 10), in prostate cancer specimens from untreated patients (n = 7) and prostate cancer specimens from patients treated with Degarelix (n = 6). RESULTS: Lactate, alanine and t-choline concentrations were significantly elevated in high-grade prostate cancer samples when compared to benign samples in untreated patients. Decreased androgen levels resulted in significant decreases of lactate and t-choline concentrations in human prostate cancer biopsies. CONCLUSIONS: The reduced concentrations of lactate and t-choline metabolites due to Degarelix could in principle be monitored by in vivo 1H MRS, which suggests that it would be possible to monitor the effects of physical or chemical castration in patients by that non-invasive method.We acknowledge the support of The University of Cambridge, Cancer Research UK (C14303/A17197) and Hutchison Whampoa Limited. The Human Research Tissue Bank is supported by the NIHR Cambridge Biomedical Research Centre.This is the final version of the article. It first appeared from Springer via http://dx.doi.org/10.1007/s11306-016-1055-0