2,068 research outputs found

    ROLE OF EFFECTIVE QUALITY RISK MANAGEMENT IN DRUG SAFETY PROJECT

    Get PDF
    Identifying risk is one of the key topics of discussion in project planning and update meetings. Project managers have to identify and manage different risks at various levels of projects. These risks must be managed and eradicated in the effective and structured manner to perform effective quality risk management and thus leading to adequate project management. The research investigates the potential root cause of the quality risk management issues using tools such as the fishbone diagram (Ishikawa), 5-Whys, FTA etc. which could remedy this situation. An effectiveness check measure can also be implemented after applying corrective/preventive actions to ensure that quality is met at each step of the process. Over 90 articles were searched using keywords risk minimization plan, benefit-risk assessment, drug safety, and pharmacovigilance. The search was further narrowed to 16 articles which had information based on human studies and drug safety. Non-human studies and single case assessments were excluded from the research. The quality data of 20 large pharmaceutical companies were surveyed extensively and it was suggested that only limited number of projects used very rare risk management practices and most of the projects do not use all the current tools of risk management. The most extensively used method of quality risk management included failure mode and effects analysis. This technique was mostly utilized in assessing change control and failed investigations. The data of this analysis suggested that risk management strategies are not used extensively. This research recommends the practice of tools used for quality risk management such as fish-bone diagram (Ishikawa) and FTA at early stages of drug development. Effectiveness check measure is also suggested to ensure that quality is met at each step of the drug safety. There may be other risk-benefit assessment methods which are not identified by this research and further research is warranted to guarantee the success of these measures

    Navigating career success: How career commitment shapes self-efficacy and career resilience for subjective career success

    Get PDF
    Purpose– This study examines the subjective dimension of career success in the dynamic global tourism industry, specifically the relationship between Career Commitment (CC) and Subjective Career Success (SCS). It uses a serial mediation framework with self-efficacy (SE) and career resilience (CR) as mediators and focuses on tourism professionals. Research methodology – We developed a theoretical serial mediation model to investigate this relationship. We conducted regression analysis using SPSS version 25 and AMOS (the Process Macro model 6) to test our proposed hypotheses. A total of 357 employees from various tourism-related organizations participated in this research. Findings – Employees who invested in their careers reported higher satisfaction with SCS in their working lives. Independently and consecutively, SE and CR influenced the association between CC and SCS. Research implications and Originality – The implications of this research extend to individuals and tourism organizations. For individuals, it provides a deeper understanding of how CC, SE and CR interact to manage the complexities of the tourism industry and promote professional success. For organizations, it highlights the importance of promoting CC through effective career development initiatives that can lead to a competent and motivated workforce, which ultimately increases employee engagement and retention

    PSO Algorithm Based Resource Allocation for OFDM Cognitive Radio

    Get PDF
    With the development of remote correspondences, the issue of data transmission lack has turned out to be more conspicuous. Then again, to sense the presence of authorized clients, range detecting procedures are utilized. Vitality recognition, Matched channel identification and Cyclo-stationary component location are the three ordinary techniques utilized for range detecting. However there are a few downsides of these strategies. The execution of vitality indicator is helpless to instability in noise power. Coordinated channel range detecting strategies require a devoted collector for each essential client. Cyclo-stationary element Detection requires parcel of calculation exertion and long perception time. This proposition talks about the routine vitality location strategy and proposed enhanced vitality identification technique utilizing cubing operation. Additionally, cyclic prefix based range detecting is talked about in this theory. Scientific Description of vitality location and cyclic prefix based range detecting strategies is likewise delineated for fading channels

    A study on Social Maturity, School Adjustment and Academic achievement among residential school girls

    Get PDF
    The present study is aimed at studying the relationship between Social Maturity, School Adjustment and levels of Academic achievement among residential school girl students. The study was conducted on a sample of 347 girls from class ix –xii at an all girls residential school of North India. Dr. Nalini Rao’s Social Maturity Scale (RSMS) was used to measure social maturity, Sinha & Singh’s Adjustment Inventory for School Students (AISS) was used to measure school adjustment and   aggregate score of the students in the year end final examination was taken to assess level of their academic achievement. The results indicated a significant relationship between social maturity and school adjustment. Also, significant difference existed between the school adjustments of the three groups i.e. low, high and average levels of academic achievement. Key words: Residential school, Social maturity, School Adjustment, Academic achievement

    Remote preconditioning by aortic constriction: affords cardioprotection as classical or other remote ischemic preconditioning? Role of iNOS

    Get PDF
    Dose remote preconditioning by aortic constriction (RPAC) affords cardioprotection similar to classical or other remote ischemic preconditioning stimulus? Moreover study was also designed to investigate role of inducible nitric oxide synthase in remote preconditioning by aortic constriction. There are sufficient evidences that "ischemic preconditioning" has surgical applications and afford clinically relevant cardioprotection. Transient occlusion of circumflex artery, renal artery, limb artery or mesenteric artery preconditions the myocardium against ischemia reperfusion injury in case of ischemic heart disease leading to myocardial infraction. Here abdominal aorta was selected to produce RPAC. Four episodes of Ischemia-reperfusion of 5 min each to abdominal aorta produced RPAC by assessment of infract size, LDH and CK. These studies suggest RPAC produced acute (FWOP) and delayed (SWOP) cardioprotective effect. RPAC demonstrated a significant decrease in Ischemia-reperfusion induced release of LDH, CK and extent of myocardial infract size. L-NAME (10 mg/Kg i.v.), Aminoguanidine (150 mg/Kg s.c.), Aminoguanidine (300 mg/Kg s.c.), S-methyl isothiourea (3 mg/Kg i.v.), 1400W (1 mg/Kg i.v.) administered 10 min. before global ischemia reperfusion produced no marked effect. Aminoguanidine (150 mg/Kg s.c.), Aminoguanidine (300 mg/Kg s.c.), S-methyl isothiourea (3 mg/Kg i.v.), 1400W (1 mg/Kg i.v.) pretreatment after RPAC produced no significant effect on acute RPAC induced decrease in LDH, CK and infract size, whereas L-NAME (10 mg/Kg i.v.) increased RPAC induced decrease in LDH, CK and infract size. Most interesting observation is in delayed RPAC, where all NOS inhibitors pretreatment attenuate RPAC induced decrease in LDH, CK and infract size. In conclusions, "Remote preconditioning by aortic constriction" (RPAC) affords cardioprotection similar to classical or other remote ischemic preconditioning stimulus. Moreover, late or delayed phase of RPAC has been mediated by inducible nitric oxide synthase (iNOS) whereas it has not involved in acute RPAC

    Elective versus emergency caesarean section: differences in maternal outcome

    Get PDF
    Background: Caesarean section is a life-saving surgical procedure when certain complications arise during pregnancy or labour. The use of CS worldwide has increased worldwide unprecedented levels although the gap between higher- and lower-resource settings remains. The present study evaluates the difference in maternal outcome in elective versus emergency caesarean sections in our institute.Methods: The study included first 65 cases of emergency caesarean section (group A) and during the study period, first 65 elective caesarean section (group B) if they fulfilled the inclusion criteria. Various intra operative and postoperative events were recorded which included intra operative complications, postpartum haemorrhage and transfusion indices.Results: The most common indication of caesarean section in group A was fetal distress (27.7%). In group B most caesarean sections were classified under 5 followed by class 6, the most common indication being previous caesarean section (27.6%). It was observed that pre-operative mean haemoglobin in group A was 10.6 g/dl and in group B was 11.2g/dl. A drop of 1.36 g/dl in group A and 1.10 g/dl in group B was observed in the post-op period. Cross match / transfusion ratio 1.5 in group A and  2 in group B, transfusion probability ratio was 60 % in group A and  66.7%  in group B and transfusion index was 1 in group A and  group B. There was significantly higher contraception acceptance in group B compared to group A.Conclusions: Elective caesarean section has more favourable maternal outcome as compared to emergency caesarean section as the former is done under controlled and planned circumstances.  However, there should be stringent audit to scrutinise indication of caesarean section, outcome of caesarean and blood transfusion practices

    Epidemiology of MTP in a tertiary care center over a period of 3 years

    Get PDF
    Background: Medical termination of pregnancy was legalized in India under the MTP act of 1971 which states that all the women can legally have an abortion up to 20 weeks of gestation if indicated. This study is a retrospective analysis of incidence, indication, the age group availing the facility, socio-demographic and obstetric profile of MTP seekers and the method of contraception followed after MTP.Methods: A retrospective 3-year data was analyzed by MTP register of the hospital as a reference.Results: The incidence rate of MTP is 96/1000 live births in the institute. The main reason for MTP is failure of contraception which highlights the unmet need of contraception and counselling. Majority of the age group availing MTP belonged to 16-20 years. Most of the women were   from urban slums, were illiterate and belonged to class IV and V according to Prasad’s classification. Mostly MTP seekers were parous, having ≥2 living children, and maximum no. of them went to private hospitals for their previous MTP. Medical method was the most favoured method of the care giver as well as of the patient. OCP was the choice of contraception after MTP. Religious difference is still very evident in availing   MTP services which can be minimized by tactful counselling. Conclusion: MTP act of 1971 opened new horizons for the unwanted pregnancies. Young population opting for MTP indicates the unmet need of contraception and counselling suggesting that implementation and integration of MTP services should be at the root level

    Methods of Data Access in Cloud Computing and It’s Challenges in Network Security

    Get PDF
    Cloud computing owes to its potency, value effectiveness, flexibility and quantifiability for being a trend setting technology. In this paper, a cloud computing and education based theory has been studied and analyzed. This paper is based on the utilizations of cloud computing services in network security and its applications

    A Review on Prevention against Sun Damage

    Get PDF
    Tanning is the increase in skin pigment- melanin; it causes the change in color of our skin. Excessive tanning causes skin damage. It is over- exposure to the UV rays from the sun. The supreme cause of skin cancer is believed to be the over exposure to the solar radiation which is the medley of ultra-violet radiation (UVA, UVB, and UVC), and visible light. UVB is the stronger component amongst the three, when it comes to causation of cancer, sunburn to humans or damage to DNA. In this review paper, the measures taken to avoid sun damage are discussed. The ancient approach to this included the use of herbal sunscreen. Whereas, new advancements include, a tan timer bikini which beeps at a particular interval, reminding you to cover yourself. The other device is a French company (Spinali Design) based bikini, named Neviano, which reminds the user to re-apply sunscreen
    • …
    corecore