Cross-corpus Readability Compatibility Assessment for English Texts

Text readability assessment has gained significant attention from researchers in various domains. However, the lack of exploration into corpus compatibility poses a challenge as different research groups utilize different corpora. In this study, we propose a novel evaluation framework, Cross-corpus text Readability Compatibility Assessment (CRCA), to address this issue. The framework encompasses three key components: (1) Corpus: CEFR, CLEC, CLOTH, NES, OSP, and RACE. Linguistic features, GloVe word vector representations, and their fusion features were extracted. (2) Classification models: Machine learning methods (XGBoost, SVM) and deep learning methods (BiLSTM, Attention-BiLSTM) were employed. (3) Compatibility metrics: RJSD, RRNSS, and NDCG metrics. Our findings revealed: (1) Validated corpus compatibility, with OSP standing out as significantly different from other datasets. (2) An adaptation effect among corpora, feature representations, and classification methods. (3) Consistent outcomes across the three metrics, validating the robustness of the compatibility assessment framework. The outcomes of this study offer valuable insights into corpus selection, feature representation, and classification methods, and it can also serve as a beginning effort for cross-corpus transfer learning.Comment: 14 pages,17 figure

Association between Cognitive Distortion, Type D Personality, Family Environment, and Depression in Chinese Adolescents

Purpose. Depression prevalence and risk increase among adolescents are related to biological, psychosocial, and cultural factors. Little is known about the association between cognitive distortion, type D personality, family environment, and depression. The aim of this paper was to examine the relationships of cognitive distortion, type D personality, family environment, and depression in a sample of Chinese adolescents. Methods. A sample of Chinese adolescents with depression and the controls were investigated cross-sectionally with life orientation test-revised (LOT-R), type D personality Scale-14 (DS14), family environment scale (FES), and Zung self-depression scale (SDS); respectively, all scales were administered in Chinese. Results. Chinese-depressed adolescents showed more cognitive distortion, type D personality, and adverse family environment than control groups. Furthermore, lower level of Optimism, negative affectivity, and poor family cohesion may increase the risk of depression in Chinese adolescents. Conclusions. Our study indicates that lower level of Optimism, Negative Affectivity, and poor Family Cohesion factors were implicated to contribute to depression in Chinese adolescents. Lower level of optimism and negative affectivity may be crucial associated factors of depression among these samples. our findings pointed to the importance of broad screening and intervention of vulnerable population

A Pilot Study on Real-time Monitoring of Heart Rate and Movement Speed in Middle-distance Race of Physical Education Classes

In Chinese universities, students need to participate in the middle-distance-race. Normally, female students are required to participate in the race of 800 meters, while male students are required to participate in the race of 1000 meters. However, it is difficult for teachers to grasp the real time information of students during the race. And there is a lack of timely communications between the teachers and students. Focusing on this issue, this study, with the use of POLAR heart rate sensor and other modern information technologies, expands the original function of the sensor to achieve a concurrent operation of detecting heart rates and automatically measuring the movement speed. The researchers have successfully designed a micro system to monitor the process of middle-distance race. Moreover, the study also engages in a preliminary experiment verification so as to provide object and effective reference and basis for the middle-distance race physical education teaching in universities

Scoulerine promotes cytotoxicity and attenuates stemness in ovarian cancer by targeting PI3K/AKT/mTOR axis

In women, ovarian cancer is a common gynecological cancer associated with poor prognosis, reoccurrence and chemoresistance. Scoulerine, a benzylisoquinoline alkaloid, has been reported effective against several carcinomas. Thus, we investigated the impact of scoulerine on ovarian cancer cells (OVCAR3). Cell viability was assessed by MTT assay, migration was determined by Boyden Chamber assay, while the invasion was monitored by Boyden Chamber assay using the matrigel. The stemness properties of OVCAR3 cells were observed by tumorsphere assay. Epithelial to mesenchymal transition (EMT) and stemness-related protein markers were monitored by real-time PCR analysis and immunoblotting. Scoulerine inhibits the viability of OVCAR3 cells with the IC50 observed at 10 µmol L–1 after 48 h treatment. Scoulerine inhibited the colony-forming ability, migration and invasiveness of OVCAR3 cells in a dose-dependent fashion. Scoulerine treatment also drastically reduced the spheroid-forming ability of OVCAR3 cells. The mesenchymal and stemness-related markers like N-cadherin, vimentin, CD-44, Oct-4, Sox-2 and Aldh1A1 were downregulated, whereas the epithelial markers like E-cadherin and CD-24 were upregulated in scoulerine-treated cells. The upstream PI3K/Akt/mTOR-axis was downregulated in scoulerine-treated cells. We concluded that scoulerine successfully perturbs the cancerous properties of OVCAR3 cells by targeting the PI3K/Akt/mTOR axis. In vivo studies revealed a substantial decrease in tumor mass and volume after scoulerine treatment. Furthermore, scoulerine treatment was found to decrease oxidative stress factors in ovarian cancer mice model. Scoulerine is a potential anticancer agent against ovarian cancer and can be considered as a lead molecule for this malignancy, provided further investigations are performed

Fast generation of mock galaxy catalogues with COLA

We investigate the feasibility of using COmoving Lagrangian Acceleration (COLA) technique to efficiently generate galaxy mock catalogues that can accurately reproduce the statistical properties of observed galaxies. Our proposed scheme combines the subhalo abundance matching (SHAM) procedure with COLA simulations, utilizing only three free parameters: the scatter magnitude ($\sigma_{\rm scat}$) in SHAM, the initial redshift ($z_{\rm init}$) of the COLA simulation, and the time stride ($da$) used by COLA. In this proof-of-concept study, we focus on a subset of BOSS CMASS NGC galaxies within the redshift range $z\in [0.45, 0.55]$. We perform $\mathtt{GADGET}$ simulation and low-resolution COLA simulations with various combinations of $(z_{\rm init}, da)$, each using $1024^{3}$ particles in an $800~h^{-1}{\rm Mpc}$ box. By minimizing the difference between COLA mock and CMASS NGC galaxies for the monopole of the two-point correlation function (2PCF), we obtain the optimal $\sigma_{\rm scat}$. We have found that by setting $z_{\rm init}=29$ and $da=1/30$, we achieve a good agreement between COLA mock and CMASS NGC galaxies within the range of 4 to $20~h^{-1}{\rm Mpc}$, with a computational cost two orders of magnitude lower than that of the N-body code. Moreover, a detailed verification is performed by comparing various statistical properties, such as anisotropic 2PCF, three-point clustering, and power spectrum multipoles, which shows similar performance between GADGET mock and COLA mock catalogues with the CMASS NGC galaxies. Furthermore, we assess the robustness of the COLA mock catalogues across different cosmological models, demonstrating consistent results in the resulting 2PCFs. Our findings suggest that COLA simulations are a promising tool for efficiently generating mock catalogues for emulators and machine learning analyses in exploring the large-scale structure of the Universe.Comment: 24 pages, 14 figures, 4 table

The influence of gratitude on pre-service teachers’ career goal self-efficacy: Chained intermediary analysis of meaning in life and career calling

ObjectiveThe aim of the study was to explore the relationship among gratitude, meaning in life (MIL), career calling, and career goal self-efficacy (CGSE) of the pre-service teachers in the Free Teacher Education program in China and the internal mechanism of action.MethodsIn this study, gratitude, MIL, career calling, and CGSE questionnaires were used to investigate 801 pre-service teachers. IBM SPSS 25.0 and AMOS 24.0 were used for data processing, and SPSS macro program Model 6 was used for the mediating mechanism.Results(1) Gratitude was positively correlated with MIL and career calling. MIL was positively correlated with career calling. Gratitude, MIL, and career calling were significantly and positively associated with CGSE. (2) Gratitude influences pre-service teachers’ CGSE mainly through the independent intermediary of MIL and career calling, and the chain intermediary of MIL→career calling, three indirect effects.ConclusionGratitude indirectly predicts CGSE of pre-service teachers not only through the independent intermediary of MIL and career calling but also through the chain intermediary of MIL and career calling

Changes in interleukin-27 levels in patients with acute coronary syndrome and their clinical significance

Background This study evaluated changes in interleukin (IL)-27 levels in patients with acute coronary syndrome (ACS) and their influence on Th1, Th2, and Th17 cells. Methods Serum levels of IL-27, IL-4, IL-17, and interferon (IFN)-γ in healthy subjects as well as patients with ACS, including stable angina pectoris (SA), unstable angina pectoris (UA), and acute myocardial infarction (AMI), were determined using an enzyme-linked immunosorbent assay. The proportions of Th1, Th2, and Th17 cells among peripheral blood mononuclear cells (PBMCs), were measured using flow cytometry, after incubation with phorbol myristate acetate (PMA) for 4 h. The proportions of Th1 and Th17 cells among PBMCs in AMI and UA were detected after stimulation with IL-27 or PMA + IL-27 for 4, 8, and 12 h. Results Serum levels of IL-27 in patients with AMI and UA were significantly lower than those in SA and control groups, while serum levels of IL-17 and IFN-γ in AMI and UA groups were dramatically increased compared to those in SA and healthy control groups. However, there were no statistically significant differences in serum IL-4. The proportions of Th1 and Th17 cells among PBMCs were statistically significantly higher in the AMI and UA groups than those in the SA and control groups, while there was no statistically significant difference in the proportion of Th2 cells among different groups. For patients with AMI and UA, the effect of co-stimulation of PBMCs with PMA and IL-27 was not significantly different from that of PMA single stimulation, while PMA + IL-27 co-stimulation lowered the Th17 cell proportion significantly compared to PMA single stimulation. Discussion Compared to SA patients and healthy controls, patients with ACS (AMI + UA) had lower serum levels of IL-27 and higher proportions of PBMC Th1 and Th17 cells, which could be attributed to the inhibitory effects of IL-27 on the proliferation of Th17 cells. These results indicated that IL-27 could be a novel therapeutic target in ACS patients

(−)-Dimethyl 3,3′-diphenyl-2,2′-[pyridine-2,6-diylbis(carbonyl­imino)]dipropanoate

The title compound, C27H27N3O6, a bis-amide derivative, is also a chiral amino acid ester with l-phenyl­alanine methyl ester groups as amine substituents. The pyridine ring is oriented at dihedral angles of 89.69 (3) and 62.95 (3)° with respect to the phenyl rings, while the dihedral angle between the phenyl rings is 60.76 (3)°. In the crystal structure, inter­molecular N—H⋯O hydrogen bonds link the mol­ecules into chains. One of the carbonyl O atoms and one of the meth­oxy CH3 groups are disordered over two positions. The O atom was refined with occupancies of 0.69 (13) and 0.31 (13), while C and H atoms were refined with occupancies of 0.69 (8) and 0.31 (8)

Effects of Fallow Management Practices on Soil Water, Crop Yield and Water Use Efficiency in Winter Wheat Monoculture System: A Meta-Analysis

Winter wheat monoculture is a predominant cropping system for agricultural production in dry areas. However, fallow management effects on soil water conservation and crop yield and water use have been inconsistent among studies. We selected 137 studies and performed a meta-analysis to test the effects of tillage and mulching during the fallow period on precipitation storage efficiency (PSE), soil water storage at wheat planting (SWSp), crop yield, evapotranspiration (ET), and water use efficiency (WUE). Compared to conventional tillage (CT), conservation tillage during fallow period overall increased PSE, SWSp and wheat yield by 31.0, 6.4, and 7.9%, respectively, but did not affect ET and WUE. No tillage (NT) had a better performance on soil water conservation during fallow period but a similar effect on wheat yield and WUE compared to reduced tillage (RT) and subsoil tillage (ST). Compared to no mulching, fallow mulching practices overall increased PSE by 19.4%, but had a non-significant impact on SWSp, wheat yield, and ET. Compared to straw mulching, film mulching, and stubble mulching during fallow period, cover cropping as a biological mulching decreased SWSp, wheat yield, and WUE significantly. Wheat WUE was improved by straw mulching but not affected by film mulching and stubble mulching. Strong interactions between tillage method and mulching practices were found for most variables. NT with fallow mulching or with no mulching exhibited a greater impact on soil water conservation during fallow period compared to other combinations. The effects of tillage and mulching during fallow period on soil water conservation and wheat yield and water use also varied with soil and climatic conditions. Overall, NT in combination with straw mulching significantly increased SWSp, PSE, wheat yield, and WUE and can be the best fallow management practice for winter wheat production in varying edaphic and climatic conditions