Kikuchi-Fujimoto disease in a young female with discoid lupus and alopecia

Kikuchi-Fujimoto disease is an uncommon, benign, autoimmune condition characterized by lymphadenopathy, fever, and neutropenia. It is a self-contained condition of unidentified etiology. A 38-year-old female of Iranian Kurdish origin referred to us with multiple neck swellings, fever, and generalized arthropathy. There was no weight loss and no history of tuberculosis, medication intake, or allergy. Clinical examination revealed bilateral large, mobile, and tendercervical lymphadenopathy. Cardiovascular, respiratory, and neurological examination was normal. The patient had leucopenia and thrombocytopenia. Kikuchi-Fujimoto disease must be considered in the differential diagnosis of a female patient with fever and cervical lymphadenopathy

Ph duyarlı polisebasik anhidrit bazlı nanokürelerin ilaç taşıyıcı sistem olarak hazırlanması

TÜBİTAK MAG15.06.2012Son yıllarda, özellikle kanser hastalığında teşhis ve tedavi amaçlı kullanılmak üzere, nano boyutta çeşitli organik ve inorganik sistemlerin geliştirilmesi büyük önem kazanmıştır ve bu konuda yoğun araştırmalar yapılmaktadır. Farmasötik açıdan bakıldığında, ideal bir ilaç taşıyıcı, küçük parçacık boyutunda ve yüksek ilaç yüklenme kapasitesinde olmalı, kanda uzun süre dolaşabilme özelliği göstermeli, biyobozunur olmalı ve bozunduğu kimyasallar olumsuz yan etki göstermeden vücut tarafından kolayca emilebilmelidir. Polisebasik anhidritler, iyi biyouyumluluk, kontrollu ve yüzeyden bozunma özelliği ve düşük maliyet gibi tercih edilen özellikleri nedeni ile ilaç taşıyıcı sistemlerin yapımında ümit veren polimerlerdir. İlaç taşıyıcı sistemler konusunda yapılan son gelişmeleri göz önüne alırsak, özgün ilaç taşıyıcı yaklaşımları, nano boyuttaki taşıyıcıların kanser hücrelerine hedeflenmesini ve sadece o bölgede salım yaparak etkin olmasını sağlayacak tasarımların geliştirilmesini yönündedir. Bu nedenle, etkin tümör-hedefli terapi için, taşıyıcının kimyasal yapısının yanı sıra, tümör tespit edebilme, sıcaklık veya pH duyarlılığı gibi kriterler de önem taşımaktadır. Bu çalışmanın amacı, kanser ilaç taşıyıcısı olarak polisebasik anhidrit (PSA) nanokürelerin tasarlanması ve sentezlenmesi yanı sıra akıllı ve pH duyarlı bir nano ilaç taşıyıcı sistem elde etmek amacıyla ilaç yüklü matrisin pH duyarlı bir molekül ile kaplanmasıdır. Polihistidin, pH duyarlı molekül olarak seçilmiş ve hazırlanan PSA nanoküreler polihistidin ile kaplanmıştır. PSA nano taşıyıcılara Doksorubisin kanser ilacı yüklenmiş, nano taşıyıcılar polihistidin ile kaplanarak pH duyarlı yapılmış ve bu sistemlerden ilaç salım kinetiği, asidik, nötr ve bazik olarak hazırlanan üç farklı pH tampon çözelti ortamında incelenmiştir. Nano parçacıkların fiziksel ve kimyasal özellikleri, Fourier dönüşümlü kızılötesi spektroskopisi (FTIR), dinamik ışık saçılım spektrometresi (DLS), ultraviyole ve görünür ışık absorpsiyon spektroskopisi (UV-VIS), parçacık boyut ölçücü (PA) ve taramalı elektron mikroskobu (SEM) ile karakterize edilmiştir.In the recent years, development of various organic and inorganic nano sized systems to be used especially in cancer for diagnosis and therapy has gained great interest, and intense research is carried out on this subject. In pharmaceutical aspect, an ideal drug carrier should have high loading capacity with small particle size, demonstrate prolonged circulation in the blood, should be biodegradable and the metabolite chemicals should be bio-absorbable by the body without causing any negative side effect. Polysebacic anhydrides are promising polymers in the formation of drug delivery systems because of their preferable properties such as good biocompatibility, controlled surface erosion and low cost. Regarding as the recent trends for drug delivery system design, the novel approaches for drug carriers are mainly based on development of nano size drug carriers which are targeted to cancer cells and release the drug only in that area. Thus, for an effective tumour-targeted delivery, further criteria such as detection of tumour and sensitivity to temperature or pH, besides its chemical structure gains importance. In this study, the aim is to design and synthesize polysebacic anhydride (PSA) nano spheres as anti cancer drug carrier, and to coat the drug-loaded matrix with a pH sensitive molecule in order to get an intelligent and pH sensitive nano drug carrier system. Polyhistidine was choosen as pH sensitive molecule and the prepared PSA nanospheres were coated with polyhistidine. PSA nano carriers were loaded with Doxorubicin anti-cancer drug, nano spheres were coated with polyhistidine in order to introduce pH sensitivity, and the drug release kinetics from these systems were examined in three different buffer media prepared as acidic, neutral and basic media. The physical and chemical properties of the nano particles were characterized by Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), ultraviolet and visible absorption spectroscopy (UV-VIS), particle sizer (PA), and scanning electron microscopy (SEM)

Multi-Cultural Curriculum Planning Approaches in Higher Education

Curriculum as a political document in every society must reflect its values and basic policies. In this research some approaches to multi-cultural curriculum planning in higher education have been presented, the results of which could be applicable in the Ministry of Higher Education (for all Universities), Farhangian University, and Shahid Rajaiee Teachers’ Training University. The research is a practical one using a descriptive-analytical methodology and library or documented study. It has also carried out a field survey obtaining the needed info through interviews and questionnaires. Using Cochran Model, the sampling consisted of 373 persons from the statistical population of 10000 professors, staff,  and university students studying within the period of 1391 to 1396, pursuing their continuous Bachelor Degree in Farhangian University. In this research SWOT method has been used for analyzing strengths, weaknesses, opportunities, and threats, and presenting the most important policies of multi cultural curriculum. Moreover, the strategic model of SOAR has been applied to planning the strategy of strengths and explaining the opportunities, ideals, and results. Then with applying the quantitative strategic planning matrix, the various strategy choices have been identified and assessed. We can sum پ up the best strategy for multi-cultural curriculum planning as setting up the curriculum and syllabus on the basis of the whole country's cultural diversity to the extent that the policy of “unity in plurality” will be implemented properly

Assosiation study between IL1RA gene polymorphism with febrile convulsion in Shahrekord children

زمینه و هدف: امروزه تب و تشنج بخش قابل ملاحظه ای از موارد بستری کودکان را در بیمارستان ها به خود اختصاص داده است. با توجه به تحقیقات اخیر که نوعی ارتباط مثبت بین وجود سابقه خانوادگی برای تشنج (از نظر نوع و سن بروز بیماری در کودک) و ابتلا به این بیماری را نشان می دهد، این مطالعه با هدف بررسی ارتباط پلی مورفیسم توالی های ریز اقماری ژن IL1RA (Inter Leukine 1 Receptor Antagonism) و استعداد ابتلا به بیماری تشنج ناشی از تب کودکان شهرکرد انجام شد. روش بررسی: در این مطالعه موردی- شاهدی تعداد 100 بیمار مبتلا به تشنج ناشی از تب مراجعه کننده به بخش های اطفال و اورژانس بیمارستان هاجر شهرکرد و همچنین تعداد 130 کودک سالم انتخاب گردید. نمونه های خون تهیه و پس از استخراج DNA با استفاده از پرایمرهای اختصاصی مربوط به ژن 1RA IL، واکنش PCR جهت تکثیر ژن مربوطه صورت پذیرفت و در نهایت با مقایسه اندازه قطعات VNTR (Variable Number Tandem Repeat) نتایج با استفاده از آزمون کای اسکوار تحلیل شد. یافته ها: میانگین سن کودکان گروه بیمار 4/1±4/3 سال و میانگین سنی کودکان گروه کنترل 3/1±4/3 سال بود. 44 مورد از کودکان بیمار سابقه خانوادگی تشنج داشتند. فراوانی ژنوتیپی آلل 1 و آلل 2 ژن IL1RA به ترتیب در گروه بیمار 56 و 10 و در گروه کنترل 4/55 و 9/6 بود. برای آلل 1 و 2 از نظر پلی مورفیسم در این ژن تفاوت آماری معنی داری بین دو گروه مشاهده نشد (05/0P>). نتیجه گیری: در کودکان شهرکرد ارتباطی بین پلی مورفیسم های این ژن و ابتلا به بیماری تشنج ناشی از تب وجود ندارد

Paclitaxel-loaded biodegradable ROS-sensitive nanoparticles for cancer therapy

Source at https://doi.org/10.2147/IJN.S208938. Background: Reactive oxygen species (ROS), such as hydrogen peroxide and superoxide, trigger biodegradation of polymer-based nanoparticles (NPs) bearing pinacol-type boronic ester groups. These NPs may selectively release their cargo, in this case paclitaxel (PTX), at the high levels of ROS present in the intracellular environment of inflamed tissues and most tumors. Purpose: The main objective was to determine anti-tumor efficacy of PTX-loaded ROS-sensitive NPs and to examine whether macrophage infiltration had any impact on treatment efficacy. Methods: NPs were synthesized and their characteristics in the presence of H2O2 were demonstrated. Both confocal microscopy as well as flow cytometry approaches were used to determine degradation of ROS-sensitive NPs. HeLa cells were cultured in vitro and used to establish tumor xenografts in nude mice. In vivo experiments were performed to understand toxicity, biodistribution and anti-tumor efficacy of the NPs. Moreover, we performed immunohistochemistry on tumor sections to study infiltration of M1 and M2 subsets of macrophages. Results: We demonstrated that PTX delivered in NPs containing a ROS-sensitive polymer exhibits a better anti-tumor efficacy than PTX in NPs containing ROS-non-sensitive polymer, free PTX or Abraxane® (nab-PTX). The biodistribution revealed that ROS-sensitive NPs exhibit retention in liver, spleen and lungs, suggesting a potential to target cancer metastasizing to these organs. Finally, we demonstrated a correlation between infiltrated macrophage subsets and treatment efficacy, possibly contributing to the efficient anti-tumor effects. Conclusion: Treatment with ROS-sensitive NPs containing PTX gave an improved therapeutic effect in HeLa xenografts than their counterpart, free PTX or nab-PTX. Our data revealed a correlation between macrophage infiltration and efficiency of the different antitumor treatments, as the most effective NPs resulted in the highest infiltration of the anti-tumorigenic M1 macrophages

Cultural Requirements of Policy Making System for Hijab and Dignity

Policy making and policy measures is important in the social system. occurs. Policy maker aimed to achieve cultural requirements of policy making system by interaction stale and society. After the Islamic Revolution of Iran. the strengths and weaknesses of the different levels of the system politically has been accompanied in the field of moral and sexual dignity and chastity, aside from the basic necessity of building systems - Iranian, coordination and harmony of the system was not relevant. That is in the realm of theoretical ideas and goals are expressed in practice, the relationship between logical and measurable programs are executed with the goals and policies have been developed. measures to improve processes, motivate and educate individuals and groups, and to monitor the development of information systems

Hyalinizing Clear Cell Carcinoma of Buccal Vestibule: A Rare Case

Hyalinizying clear cell carcinoma is a rare tumor which affects women more than men and is more common in minor salivary glands. The purpose of this paper was to describe a case of hyalinizing clear cell carcinoma of buccal vestibule in a 55-year-old woman. It is important to differentiate this neoplasm from other tumors with clear cell features because of their differences in treatment and clinical outcom

Anti-cancerous effect of albumin coated silver nanoparticles on MDA-MB 231 human breast cancer cell line

With the aim of making specific targeting of silver nanoparticles as a drug for tumor cells and developing new anticancer agents, a novel nano-composite was developed. Albumin coated silver nanoparticles (ASNPs) were synthesized, and their anti-cancerous effects were evaluated against MDA-MB 231, a human breast cancer cell line. The synthesized ASNPs were characterized by spectroscopic methods. The morphological changes of the cells were observed by inverted, florescent microscopy and also by DNA ladder pattern on gel electrophoresis; the results revealed that the cell death process occurred through the apoptosis mechanism. It was found that ASNPs with a size of 90 nm and negatively charged with a zeta-potential of about −20 mV could be specifically taken up by tumor cells. The LD50 of ASNPs against MDA-MB 231 (5 μM), was found to be 30 times higher than that for white normal blood cells (152 μM). The characteristics of the synthesized ASNPs included; intact structure of coated albumin, higher cytotoxicity against cancer cells than over normal cells, and cell death based on apoptosis and reduction of gland tumor sizes in mice. This work indicates that ASNPs could be a good candidate for chemotherapeutic drug

Clinical Characteristics and symptoms of patients with the recurrence of COVID-19 and underlying disease in Taleghani and Valiasr hospitals in Khuzestan, Iran

Background and aims: Due to the widespread prevalence of COVID-19 in the world, especially in Iran, this study attempted to evaluate risk factors associated with the recurrent of COVID-19 patients in health-care centers of Khuzestan province.Methods: This study was conducted on patients admitted to Taleghani and Valiasr hospitals, with positive COVID-19 real-time-polymerase chain reaction (RT-PCR), from 20 February 2020 to 19 January 2021. Meanwhile, 398 cases with the recurrent of COVID-19 were included. Investigations were conducted as follows, demographic characteristics, clinical signs and symptoms, and underlying disease, history of ICU hospitalization, international travel, and contacts with foreign nationals and mortality. The collected data were recorded by laboratory experts.Results: Out of 398 patients, 251 (63.07%) were male, and 147 (36.93%) were female. The average age was 49.39 years old. None of the patients were hospitalized in ICU. Most patients were in 30-40 years (24.37%). International travelling and contact with foreigners was observed in only 25 (6.28%) cases. The most underlying diseases were hypertension and diabetes. In this study, the number of patients who died was 253 (63.57%).Conclusion: Due to the severe symptoms and higher mortality among COVID-19 recurrent patients with underlying disease, it is recommended to give more attention to COVID-19 recurrent patients with underlying diseases such as diabetes and hypertension. Presenting the results of this study to health-care systems might help a better understanding of risk-factors associated with the recurrent COVID-19 disease, leading to a better control and management of this patients.Keywords: COVID-19, SARS-CoV-2, clinical characteristics, recurrence, Khuzestan, Ira