Assessing Heavy Metals in Sediment of Beijing-Hangzhou Grand Canal by Statistical and Geochemical Analysis

Statistical analysis and geochemical approaches were exploited for the heavy metals (HMS) assessment in sediments from Beijing-Hangzhou Grand Canal. Single source (crustal) was identified using principal component analysis (PCA). Furthermore, enrichment factor (EF) denoted contaminated sites by HMS in the study area while EF value reveal minor enrichment or no anthropogenic enrichment from most sites. The anthropogenic activities that suggested to be primarily from agriculture and automobile repair discharge

Synthesis and Antitumor Activity of 5-Bromo-7-azaindolin-2-one Derivatives Containing a 2,4-Dimethyl-1H-pyrrole-3-carboxamide Moiety

We report herein the design and synthesis of a series of novel 5-bromo-7-azaindolin-2-one derivatives containing a 2,4-dimethyl-1H-pyrrole-3-carboxamide moiety. These newly synthesized derivatives were evaluated for in vitro activity against selected cancer cell lines by MTT assay. Results revealed that some compounds exhibit broad-spectrum antitumor potency, and the most active compound 23p (IC50: 2.357–3.012 μM) was found more potent than Sunitinib (IC50: 31.594–49.036 μM) against HepG2, A549 and Skov-3, respectively